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公开(公告)号：US11351114B2
公开(公告)日：2022-06-07
申请号：US16522779
申请日：2019-07-26
发明人： David Charles Jackson , Amabel Tan , Weiguang Zeng
IPC分类号： A61K39/02 , A61K39/04 , A61K47/60 , A61K39/39 , A61K9/00 , A61K38/06 , A61K38/07 , A61K38/08 , C07K7/06 , A61K31/23
摘要： This invention relates to a method for treating or preventing a disease by raising an innate immune response in a subject, the method comprising administering to the subject an effective amount of a composition comprising a TLR2 moiety in solution, wherein the TLR2 moiety comprises a TLR2 agonist and wherein the disease is not treated or prevented by a humoral or cellular immune response directed against the TLR2 moiety.
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公开(公告)号：US20210230217A1
公开(公告)日：2021-07-29
申请号：US16768341
申请日：2018-12-21
发明人： David Jackson , Ian Holmes , Weiguang Zeng , Christophe Demaison
IPC分类号： C07K5/062 , C07C317/48 , C07C323/60 , A61K47/54 , A61K47/60 , A61P11/00
摘要： The present invention relates to TLR2 agonist compounds and their compositions, and the use of such compounds and compositions in the prevention and/or treatment of respiratory infections, or diseases or conditions associated with viral or bacterial infections.
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公开(公告)号：US10406100B2
公开(公告)日：2019-09-10
申请号：US15596427
申请日：2017-05-16
发明人： David Charles Jackson , Amabel Tan , Weiguang Zeng
IPC分类号： A61K39/02 , A61K39/04 , A61K47/60 , A61K39/39 , A61K9/00 , A61K38/06 , A61K38/07 , A61K38/08 , C07K7/06 , A61K31/23
摘要： This invention relates to a method for treating or preventing a disease by raising an innate immune response in a subject, the method comprising administering to the subject an effective amount of a composition comprising a TLR2 moiety in solution, wherein the TLR2 moiety comprises a TLR2 agonist and wherein the disease is not treated or prevented by a humoral or cellular immune response directed against the TLR2 moiety.
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