公开(公告)号：US20220323460A1

公开(公告)日：2022-10-13

申请号：US17094029

申请日：2020-11-10

申请人： Enanta Pharmaceuticals, Inc.

发明人： Brian C. Shook ,  In Jong Kim ,  Thomas P. Blaisdell ,  Jianming Yu ,  Joseph Panarese ,  Kai Lin ,  Michael H.J. Rhodin ,  Nicole V. McAllister ,  Yat Sun Or

IPC分类号： A61K31/5513 ,  C07D491/04 ,  C07D213/12 ,  C07D213/14 ,  A61K31/7056 ,  A61K39/42 ,  A61K39/395 ,  C07D403/12 ,  C07K16/10 ,  C07D217/14 ,  C07D243/24 ,  A61K45/06 ,  C07D217/12 ,  A61K31/4439 ,  C07D498/08 ,  A61P31/14

摘要： The present invention relates to pharmaceutical agents administered to a subject either in combination or in series for the treatment of a Respiratory Syncytial Virus (RSV) infection, wherein treatment comprises administering a compound effective to inhibit the function of the RSV and an additional compound or combinations of compounds having anti-RSV activity.

公开(公告)号：US10570153B2

公开(公告)日：2020-02-25

申请号：US15914016

申请日：2018-03-07

申请人： Enanta Pharmaceuticals, Inc.

发明人： Brian C. Shook ,  In Jong Kim ,  Thomas P. Blaisdell ,  Jianming Yu ,  Joseph Panarese ,  Yat Sun Or

IPC分类号： C07D235/24 ,  C07D403/12 ,  C07D513/04 ,  A61K31/56 ,  A61K31/58 ,  A61K31/5513 ,  A61K45/06 ,  C07D243/16 ,  C07D413/12 ,  C07D413/14 ,  C07D417/14 ,  C07D471/08 ,  C07D491/048 ,  C07D495/04 ,  C07D498/08

摘要： The present invention discloses compounds of Formula (I), or pharmaceutically acceptable salts, esters, or prodrugs thereof: which inhibit Respiratory Syncytial Virus (RSV). The present invention further relates to pharmaceutical compositions comprising the aforementioned compounds for administration to a subject suffering from RSV infection. The invention also relates to methods of treating an RSV infection in a subject by administering a pharmaceutical composition comprising the compounds of the present invention.

公开(公告)号：US20190308964A1

公开(公告)日：2019-10-10

申请号：US16449946

申请日：2019-06-24

申请人： ENANTA PHARMACEUTICALS, INC.

发明人： In Jong Kim ,  Jianming Yu ,  Thomas P. Blaisdell ,  Joseph Panarese ,  Brian C. Shook ,  Yat Sun Or

IPC分类号： C07D413/14

摘要： The present invention relates to processes and intermediates useful in the preparation of biologically active molecules, especially in the synthesis of Respiratory Syncytial Virus (RSV) inhibitors. The present invention also relates to processes and intermediates for the preparation of compounds of formula (I): In particular, the present invention also relates to processes and intermediates for the preparation of compound I-a:

公开(公告)号：US20230075366A1

公开(公告)日：2023-03-09

申请号：US17517740

申请日：2021-11-03

申请人： Enanta Pharmaceuticals, Inc.

发明人： Joseph Panarese ,  Dexter Davis ,  Samuel Bartlett ,  Katherine Chong ,  Nathaniel Kenton ,  Yat Sun Or

IPC分类号： C07D471/14

摘要： The present invention discloses compounds of Formula (I), or pharmaceutically acceptable salts, thereof: which inhibit the protein(s) encoded by hepatitis B virus (HBV) or interfere with the function of the HBV life cycle of the hepatitis B virus and are also useful as antiviral agents. The present invention further relates to pharmaceutical compositions comprising the aforementioned compounds for administration to a subject suffering from HBV infection. The invention also relates to methods of treating an HBV infection in a subject by administering a pharmaceutical composition comprising the compounds of the present invention.

公开(公告)号：US10851115B2

公开(公告)日：2020-12-01

申请号：US16023363

申请日：2018-06-29

申请人： Enanta Pharmaceuticals, Inc.

发明人： In Jong Kim ,  Joseph Panarese ,  Thomas P. Blaisdell ,  Jianming Yu ,  Brian C. Shook ,  Yat Sun Or

IPC分类号： C07D519/00 ,  A61P31/16

摘要： The present invention discloses compounds of Formula (I), or pharmaceutically acceptable salts, esters, or prodrugs thereof: which inhibit Respiratory Syncytial Virus (RSV). The present invention further relates to pharmaceutical compositions comprising the aforementioned compounds for administration to a subject suffering from RSV infection. The invention also relates to methods of treating an RSV infection in a subject by administering a pharmaceutical composition comprising the compounds of the present invention.

公开(公告)号：US20200223867A1

公开(公告)日：2020-07-16

申请号：US16739312

申请日：2020-01-10

申请人： Enanta Pharmaceuticals, Inc.

发明人： Brian C. Shook ,  In Jong Kim ,  Thomas P. Blaisdell ,  Jianming Yu ,  Joseph Panarese ,  Yat Sun Or

IPC分类号： C07D513/04 ,  A61K31/56 ,  A61K31/58 ,  A61K31/5513 ,  A61K45/06 ,  C07D243/16 ,  C07D413/12 ,  C07D413/14 ,  C07D417/14 ,  C07D471/08 ,  C07D491/048 ,  C07D495/04 ,  C07D498/08

摘要： The present invention discloses compounds of Formula (I), or pharmaceutically acceptable salts, esters, or prodrugs thereof: which inhibit Respiratory Syncytial Virus (RSV). The present invention further relates to pharmaceutical compositions comprising the aforementioned compounds for administration to a subject suffering from RSV infection. The invention also relates to methods of treating an RSV infection in a subject by administering a pharmaceutical composition comprising the compounds of the present invention.

公开(公告)号：US11058678B2

公开(公告)日：2021-07-13

申请号：US16251386

申请日：2019-01-18

申请人： Enanta Pharmaceuticals, Inc.

发明人： Joseph Panarese ,  Samuel Bartlett ,  Katherine Chong ,  Yat Sun Or

IPC分类号： A61K31/473 ,  A61K31/4355 ,  A61K31/501 ,  A61K31/506 ,  A61P31/20

摘要： The present invention discloses compounds of Formula (I), and pharmaceutically acceptable salts thereof: which inhibit the protein(s) encoded by hepatitis B virus (HBV) or interfere with the function of the HBV life cycle of the hepatitis B virus and are also useful as antiviral agents. The present invention further relates to pharmaceutical compositions comprising the aforementioned compounds for administration to a subject suffering from HBV infection. The invention also relates to methods of treating an HBV infection in a subject by administering a pharmaceutical composition comprising the compounds of the present invention.

公开(公告)号：US20210008057A1

公开(公告)日：2021-01-14

申请号：US16925666

申请日：2020-07-10

申请人： ENANTA PHARMACEUTICALS, INC.

发明人： Joseph Panarese ,  Samuel Bartlett ,  Dexter Davis ,  Nathaniel Kenton ,  Yat Sun Or

IPC分类号： A61K31/4725 ,  C07D491/147 ,  C07D495/14 ,  C07D455/03 ,  A61K38/21

摘要： The present invention discloses compounds of Formula (I), and pharmaceutically acceptable salts thereof: which inhibit the protein(s) encoded by hepatitis B virus (HBV) or interfere with the function of the HBV life cycle of the hepatitis B virus and are also useful as antiviral agents. The present invention further relates to pharmaceutical compositions comprising the aforementioned compounds for administration to a subject suffering from HBV infection. The invention also relates to methods of treating an HBV infection in a subject by administering a pharmaceutical composition comprising the compounds of the present invention.

公开(公告)号：US20200165249A1

公开(公告)日：2020-05-28

申请号：US16689448

申请日：2019-11-20

申请人： Enanta Pharmaceuticals, Inc.

发明人： Joseph Panarese ,  Dexter Davis ,  Samuel Bartlet ,  Katherine Chong ,  Nathaniel Kenton ,  Yat Sun Or

IPC分类号： C07D471/14 ,  A61K45/06

摘要： The present invention discloses compounds of Formula (I), or pharmaceutically acceptable salts, thereof: which inhibit the protein(s) encoded by hepatitis B virus (HBV) or interfere with the function of the HBV life cycle of the hepatitis B virus and are also useful as antiviral agents. The present invention further relates to pharmaceutical compositions comprising the aforementioned compounds for administration to a subject suffering from HBV infection. The invention also relates to methods of treating an HBV infection in a subject by administering a pharmaceutical composition comprising the compounds of the present invention.

公开(公告)号：US20190040084A1

公开(公告)日：2019-02-07

申请号：US16100721

申请日：2018-08-10

申请人： Enanta Pharmaceuticals, Inc.

发明人： Jianming Yu ,  Brian C. Shook ,  Thomas P. Blaisdell ,  In Jong Kim ,  Joseph Panarese ,  Kevin McGrath ,  Solymar Negretti-Emmanuelli ,  Yat Sun Or

IPC分类号： C07D519/00 ,  A61K31/554 ,  C07D491/048 ,  A61K31/551 ,  A61K45/06 ,  A61K31/55 ,  C07D495/04 ,  A61K31/553

CPC分类号： C07D519/00 ,  A61K31/55 ,  A61K31/551 ,  A61K31/553 ,  A61K31/554 ,  A61K45/06 ,  C07D401/06 ,  C07D401/14 ,  C07D487/04 ,  C07D491/048 ,  C07D495/04 ,  C07D498/04 ,  C07D513/04

摘要： The present invention discloses compounds of Formula (I), or pharmaceutically acceptable salts, esters, or prodrugs thereof: which inhibit Respiratory Syncytial Virus (RSV). The present invention further relates to pharmaceutical compositions comprising the aforementioned compounds for administration to a subject suffering from RSV infection. The invention also relates to methods of treating an RSV infection in a subject by administering a pharmaceutical composition comprising the compounds of the present invention.