公开(公告)号：US12162857B2

公开(公告)日：2024-12-10

申请号：US18139405

申请日：2023-04-26

Applicant: ENANTA PHARMACEUTICALS, INC.

Inventor： Jianming Yu ,  Xiben Li ,  Robert Leon ,  Adam Szymaniak ,  In Jong Kim ,  Yat Sun Or

IPC: C07D401/12 ,  A61K45/06 ,  A61P31/14 ,  C07D401/14 ,  C07D405/14 ,  C07D409/14 ,  C07D413/14 ,  C07D417/12 ,  C07D417/14 ,  C07D471/04

Abstract: The present invention discloses compounds of Formula (I), or pharmaceutically acceptable salts, esters, or prodrugs thereof: which inhibit Human Respiratory Syncytial Virus (HRSV) or Human Metapneumovirus (HMPV) inhibitors. The present invention further relates to pharmaceutical compositions comprising the compounds of Formula (I) for administration to a subject suffering from HRSV or HMPV infection. The invention also relates to methods of treating an HRSV or HMPV infection in a subject by administering a pharmaceutical composition comprising the compounds of the present invention.

公开(公告)号：US11912695B2

公开(公告)日：2024-02-27

申请号：US17574718

申请日：2022-01-13

Applicant: ENANTA PHARMACEUTICALS, INC.

Inventor： Kaicheng Zhu ,  Kevin McGrath ,  Solymar Negretti-Emmanuelli ,  Adam Szymaniak ,  Jianming Yu ,  In Jong Kim ,  Yat Sun Or

IPC: C07D413/14 ,  A61K31/5513 ,  A61P31/14 ,  C07D417/14 ,  A61K45/06

CPC classification number: C07D413/14 ,  A61P31/14 ,  C07D417/14 ,  A61K31/5513 ,  A61K45/06 ,  A61K31/5513 ,  A61K2300/00

Abstract: The present invention discloses compounds of Formula (I), or pharmaceutically acceptable salts, esters, or prodrugs thereof:




which inhibit Respiratory Syncytial Virus (RSV). The present invention further relates to pharmaceutical compositions comprising the aforementioned compounds for administration to a subject suffering from RSV infection. The invention also relates to methods of treating an RSV infection in a subject by administering a pharmaceutical composition comprising the compounds of the present invention.

公开(公告)号：US20220356189A1

公开(公告)日：2022-11-10

申请号：US16930622

申请日：2020-07-16

Applicant: Enanta Pharmaceuticals, Inc.

Inventor： Adam Szymaniak ,  Kevin McGrath ,  Jianming Yu ,  Tyler Mann ,  Long Nguyen ,  Kaicheng Zhu ,  In Jong Kim ,  Yat Sun Or

IPC: C07D491/052 ,  C07D471/04

Abstract: The present invention discloses compounds of Formula (I), or pharmaceutically acceptable salts, esters, or prodrugs thereof: which inhibit Human Respiratory Syncytial Virus (HRSV) or Human Metapneumovirus (HMPV) inhibitors. The present invention further relates to pharmaceutical compositions comprising the aforementioned compounds for administration to a subject suffering from HRSV or HMPV infection. The invention also relates to methods of treating an HRSV or HMPV infection in a subject by administering a pharmaceutical composition comprising the compounds of the present invention.

公开(公告)号：US20220323460A1

公开(公告)日：2022-10-13

申请号：US17094029

申请日：2020-11-10

Applicant: Enanta Pharmaceuticals, Inc.

Inventor： Brian C. Shook ,  In Jong Kim ,  Thomas P. Blaisdell ,  Jianming Yu ,  Joseph Panarese ,  Kai Lin ,  Michael H.J. Rhodin ,  Nicole V. McAllister ,  Yat Sun Or

IPC: A61K31/5513 ,  C07D491/04 ,  C07D213/12 ,  C07D213/14 ,  A61K31/7056 ,  A61K39/42 ,  A61K39/395 ,  C07D403/12 ,  C07K16/10 ,  C07D217/14 ,  C07D243/24 ,  A61K45/06 ,  C07D217/12 ,  A61K31/4439 ,  C07D498/08 ,  A61P31/14

Abstract: The present invention relates to pharmaceutical agents administered to a subject either in combination or in series for the treatment of a Respiratory Syncytial Virus (RSV) infection, wherein treatment comprises administering a compound effective to inhibit the function of the RSV and an additional compound or combinations of compounds having anti-RSV activity.

公开(公告)号：US10975094B2

公开(公告)日：2021-04-13

申请号：US16379881

申请日：2019-04-10

Applicant: Enanta Pharmaceuticals, Inc.

Inventor： Jianming Yu ,  Solymar Negretti-Emmanuelli ,  In Jong Kim ,  Yat Sun Or

IPC: C07D495/14 ,  C07D493/14 ,  C07D413/14 ,  C07D493/10 ,  A61P31/16 ,  C07D519/00

Abstract: The present invention discloses compounds of Formula (I), and pharmaceutically acceptable salts, esters, or prodrugs thereof: which inhibit Respiratory Syncytial Virus (RSV). The present invention further relates to pharmaceutical compositions comprising the aforementioned compounds for administration to a subject suffering from RSV infection. The invention also relates to methods of treating an RSV infection in a subject by administering a pharmaceutical composition comprising the compounds of the present invention.

公开(公告)号：US10570153B2

公开(公告)日：2020-02-25

申请号：US15914016

申请日：2018-03-07

Applicant: Enanta Pharmaceuticals, Inc.

Inventor： Brian C. Shook ,  In Jong Kim ,  Thomas P. Blaisdell ,  Jianming Yu ,  Joseph Panarese ,  Yat Sun Or

IPC: C07D235/24 ,  C07D403/12 ,  C07D513/04 ,  A61K31/56 ,  A61K31/58 ,  A61K31/5513 ,  A61K45/06 ,  C07D243/16 ,  C07D413/12 ,  C07D413/14 ,  C07D417/14 ,  C07D471/08 ,  C07D491/048 ,  C07D495/04 ,  C07D498/08

Abstract: The present invention discloses compounds of Formula (I), or pharmaceutically acceptable salts, esters, or prodrugs thereof: which inhibit Respiratory Syncytial Virus (RSV). The present invention further relates to pharmaceutical compositions comprising the aforementioned compounds for administration to a subject suffering from RSV infection. The invention also relates to methods of treating an RSV infection in a subject by administering a pharmaceutical composition comprising the compounds of the present invention.

公开(公告)号：US20190308964A1

公开(公告)日：2019-10-10

申请号：US16449946

申请日：2019-06-24

Applicant: ENANTA PHARMACEUTICALS, INC.

Inventor： In Jong Kim ,  Jianming Yu ,  Thomas P. Blaisdell ,  Joseph Panarese ,  Brian C. Shook ,  Yat Sun Or

IPC: C07D413/14

Abstract: The present invention relates to processes and intermediates useful in the preparation of biologically active molecules, especially in the synthesis of Respiratory Syncytial Virus (RSV) inhibitors. The present invention also relates to processes and intermediates for the preparation of compounds of formula (I): In particular, the present invention also relates to processes and intermediates for the preparation of compound I-a:

公开(公告)号：US12297209B2

公开(公告)日：2025-05-13

申请号：US18584520

申请日：2024-02-22

Applicant: Enanta Pharmaceuticals, Inc.

Inventor： Brian C. Shook ,  In Jong Kim ,  Thomas P. Blaisdell ,  Jianming Yu ,  Joseph D. Panarese ,  Yat Sun Or

IPC: A61K31/5513 ,  A61K31/56 ,  A61K31/58 ,  A61K45/06 ,  C07D243/16 ,  C07D413/12 ,  C07D413/14 ,  C07D417/14 ,  C07D471/08 ,  C07D491/048 ,  C07D495/04 ,  C07D498/08 ,  C07D513/04

Abstract: The present invention discloses compounds of Formula (I), or pharmaceutically acceptable salts, esters, or prodrugs thereof: which inhibit Respiratory Syncytial Virus (RSV). The present invention further relates to pharmaceutical compositions comprising the aforementioned compounds for administration to a subject suffering from RSV infection. The invention also relates to methods of treating an RSV infection in a subject by administering a pharmaceutical composition comprising the compounds of the present invention.

公开(公告)号：US20240360117A1

公开(公告)日：2024-10-31

申请号：US18420855

申请日：2024-01-24

Applicant: Enanta Pharmaceuticals, Inc.

Inventor： Kaicheng Zhu ,  Kevin McGrath ,  Solymar Negretti-Emmanuelli ,  Adam Szymaniak ,  Jianming Yu ,  In Jong Kim ,  Yat Sun Or

IPC: C07D413/14 ,  A61K31/5513 ,  A61K45/06 ,  A61P31/14 ,  C07D417/14

CPC classification number: C07D413/14 ,  A61P31/14 ,  C07D417/14 ,  A61K31/5513 ,  A61K45/06

Abstract: The present invention discloses compounds of Formula (I), or pharmaceutically acceptable salts, esters, or prodrugs thereof:




which inhibit Respiratory Syncytial Virus (RSV). The present invention further relates to pharmaceutical compositions comprising the aforementioned compounds for administration to a subject suffering from RSV infection. The invention also relates to methods of treating an RSV infection in a subject by administering a pharmaceutical composition comprising the compounds of the present invention.

公开(公告)号：US20230357258A1

公开(公告)日：2023-11-09

申请号：US18131405

申请日：2023-04-06

Applicant: ENANTA PHARMACEUTICALS, INC.

Inventor： Adam Szymaniak ,  Robert Leon ,  Kevin McGrath ,  Xiben Li ,  Tyler J. Mann ,  Jianming Yu ,  In Jong Kim ,  Scott Mitchell ,  Yat Sun Or

IPC: C07D491/048 ,  A61P31/14 ,  A61K45/06 ,  C07D519/00

CPC classification number: C07D491/048 ,  A61P31/14 ,  A61K45/06 ,  C07D519/00 ,  C07B2200/05

Abstract: The present invention discloses compounds of Formula (I), and pharmaceutically acceptable salts, esters, or prodrugs thereof:




which inhibit Human Respiratory Syncytial Virus (HRSV) or Human Metapneumovirus (HMPV) inhibitors. The present invention further relates to pharmaceutical compositions comprising the aforementioned compounds for administration to a subject suffering from HRSV or HMPV infection. The invention also relates to methods of treating an HRSV or HMPV infection in a subject by administering a pharmaceutical composition comprising the compounds of the present invention.