公开(公告)号：US20190117756A1

公开(公告)日：2019-04-25

申请号：US16170420

申请日：2018-10-25

Applicant: Engineered Antigens Inc.

Inventor： Anthony B. Schryvers ,  Trevor F. Moraes ,  Scott Gray-Owen

IPC: A61K39/104 ,  C07K14/22 ,  A61K39/102 ,  C07K14/285 ,  A61K39/095 ,  C07K14/195

Abstract: The disclosure provides immunogenic compositions comprising a polypeptide comprising a C-lobe domain or an N-lobe domain of a HIBP surface receptor protein obtainable from or obtained from a Gram-negative bacterial species. The HIBP surface receptor proteins have been modified in such a manner that they are unable to bind host iron binding protein. Methods of making and using these immunogenic positions to prepare animal and human vaccines are also provided.