公开(公告)号：US11123418B2

公开(公告)日：2021-09-21

申请号：US16077112

申请日：2017-02-10

Applicant: Engineered Antigens Inc.

Inventor： Trevor F. Moraes ,  Christine Chieh-Lin Lai ,  Yogesh Hooda ,  Andrew Judd ,  Anthony B. Schryvers ,  Scott D. Gray-Owen

IPC: A61K39/02 ,  A61K39/095 ,  C07K14/195 ,  C07K14/22 ,  A61K39/00

Abstract: The present disclosure relates to methods for exporting target proteins (e.g., surface lipoproteins) from the cytosol to the extracellular surface of bacterial cells using surface lipoprotein assembly modulator (SLAM) polypeptides. The use of SLAM polypeptides in a method of preparing vaccines useful in the prevention of bacterial infectious diseases is also taught.

公开(公告)号：US20210379176A1

公开(公告)日：2021-12-09

申请号：US17405620

申请日：2021-08-18

Applicant: ENGINEERED ANTIGENS INC.

Inventor： Trevor F. Moraes ,  Christine Chieh-Lin Lai ,  Yogesh Hooda ,  Andrew Judd ,  Anthony B. Schryvers ,  Scott D. Gray-Owen

IPC: A61K39/095 ,  A61K39/02 ,  C07K14/195 ,  C07K14/22

Abstract: Novel methods for exporting target proteins from the cytosol to the extracellular surface of bacterial cells are provided. The methods are useful in that they permit the preparation of vaccines for the prevention of bacterial infectious diseases.

公开(公告)号：US12296000B2

公开(公告)日：2025-05-13

申请号：US18544698

申请日：2023-12-19

Applicant: ENGINEERED ANTIGENS INC.

Inventor： Trevor F. Moraes ,  Christine Chieh-Lin Lai ,  Yogesh Hooda ,  Andrew Judd ,  Anthony B. Schryvers ,  Scott D. Gray-Owen

IPC: A61K39/02 ,  A61K39/095 ,  C07K14/195 ,  C07K14/22 ,  C12P21/06 ,  A61K39/00

Abstract: Novel methods for exporting target proteins from the cytosol to the extracellular surface of bacterial cells are provided. The methods are useful in that they permit the preparation of vaccines for the prevention of bacterial infectious diseases.

公开(公告)号：US20240181029A1

公开(公告)日：2024-06-06

申请号：US18544698

申请日：2023-12-19

Applicant: ENGINEERED ANTIGENS INC.

Inventor： Trevor F. Moraes ,  Christine Chieh-Lin Lai ,  Yogesh Hooda ,  Andrew Judd ,  Anthony B. Schryvers ,  Scott D. Gray-Owen

IPC: A61K39/095 ,  A61K39/00 ,  A61K39/02 ,  C07K14/195 ,  C07K14/22

CPC classification number: A61K39/095 ,  A61K39/02 ,  C07K14/195 ,  C07K14/22 ,  A61K2039/522 ,  A61K2039/523 ,  Y02A50/30

Abstract: Novel methods for exporting target proteins from the cytosol to the extracellular surface of bacterial cells are provided. The methods are useful in that they permit the preparation of vaccines for the prevention of bacterial infectious diseases.

公开(公告)号：US11872275B2

公开(公告)日：2024-01-16

申请号：US17405620

申请日：2021-08-18

Applicant: ENGINEERED ANTIGENS INC.

Inventor： Trevor F. Moraes ,  Christine Chieh-Lin Lai ,  Yogesh Hooda ,  Andrew Judd ,  Anthony B. Schryvers ,  Scott D. Gray-Owen

IPC: A61K39/095 ,  A61K39/02 ,  C07K14/195 ,  C07K14/22 ,  A61K39/00

CPC classification number: A61K39/095 ,  A61K39/02 ,  C07K14/195 ,  C07K14/22 ,  A61K2039/522 ,  A61K2039/523 ,  Y02A50/30

Abstract: Novel methods for exporting target proteins from the cytosol to the extracellular surface of bacterial cells are provided. The methods are useful in that they permit the preparation of vaccines for the prevention of bacterial infectious diseases.

公开(公告)号：US20190117756A1

公开(公告)日：2019-04-25

申请号：US16170420

申请日：2018-10-25

Applicant: Engineered Antigens Inc.

Inventor： Anthony B. Schryvers ,  Trevor F. Moraes ,  Scott Gray-Owen

IPC: A61K39/104 ,  C07K14/22 ,  A61K39/102 ,  C07K14/285 ,  A61K39/095 ,  C07K14/195

Abstract: The disclosure provides immunogenic compositions comprising a polypeptide comprising a C-lobe domain or an N-lobe domain of a HIBP surface receptor protein obtainable from or obtained from a Gram-negative bacterial species. The HIBP surface receptor proteins have been modified in such a manner that they are unable to bind host iron binding protein. Methods of making and using these immunogenic positions to prepare animal and human vaccines are also provided.

公开(公告)号：US20190111122A1

公开(公告)日：2019-04-18

申请号：US16077112

申请日：2017-02-10

Applicant: Engineered Antigens Inc.

Inventor： Trevor F. Moraes ,  Christine Chieh-Lin Lai ,  Yogesh Hooda ,  Andrew Judd ,  Anthony B. Schryvers ,  Scott D. Gray-Owen

IPC: A61K39/095 ,  C07K14/22

Abstract: The present disclosure relates to methods for exporting target proteins (e.g., surface lipoproteins) from the cytosol to the extracellular surface of bacterial cells using surface lipoprotein assembly modulator (SLAM) polypeptides. The use of SLAM polypeptides in a method of preparing vaccines useful in the prevention of bacterial infectious diseases is also taught.