公开(公告)号：US20180125620A1

公开(公告)日：2018-05-10

申请号：US15640873

申请日：2017-07-03

Applicant: Ension, Inc.

Inventor： Ali Hussain ,  Linda Cahalan ,  Greg Johnson ,  Mark Gartner ,  Patrick Cahalan ,  Brian J. Fill ,  Jeffrey W. Speakman

IPC: A61C15/04 ,  A61L31/04 ,  A61B17/06

CPC classification number: A61C15/041 ,  A61B17/06 ,  A61B17/06166 ,  A61B17/064 ,  A61L31/048 ,  A61L31/10 ,  A61L33/0029 ,  A61L2400/18 ,  A61M1/1698 ,  B05D1/36 ,  B05D1/62 ,  B05D3/06 ,  B05D7/02 ,  B05D2256/00 ,  B05D2258/00 ,  C08L83/04 ,  C08L23/12

Abstract: A method of treating a tubular medical device with a biomolecule comprises the steps of: a) providing a polyolefin tubular substrate forming a tubular medical device; b) cleaning the tubular polyolefin substrate; c) exposing the tubular polyolefin substrate to a reactive gas containing at least one of acrylic acid and siloxane and to plasma energy to yield a plasma-deposited coating on at least one surface of the tubular polyolefin substrate; and d) attaching a biomolecule to the polyolefin substrate following formation of the plasma-deposited coating on at least one surface of the tubular polyolefin substrate, and wherein the biomolecule is at least one of an antibacterial agent, antimicrobial agent, anticoagulant, heparin, antithrombotic agent, platelet agent, anti-inflammatory, enzyme, catalyst, hormone, growth factor, drug, vitamin, antibody, antigen, protein, nucleic acid, dye, a DNA segment, an RNA segment, protein, and peptide.

公开(公告)号：US20130343954A1

公开(公告)日：2013-12-26

申请号：US13916739

申请日：2013-06-13

Applicant: Ension, Inc.

Inventor： Mark J. Gartner ,  Brian J. Fill ,  Patrick Cahalan ,  Linda Cahalan

IPC: A61M1/16

CPC classification number: A61M1/1698 ,  A61M1/1006 ,  A61M1/101 ,  A61M1/1013 ,  A61M1/1025 ,  A61M1/1029 ,  A61M1/122 ,  A61M1/262 ,  A61M1/267

Abstract: An integrated blood pump oxygenator comprises an an impeller housing supporting an impeller; with an annular hydrogel impeller packing material adjacent the bearings and around the shaft of the impeller. The oxygenator including a rollover outlet in the form of an annular chamber extending around a center pump housing member; and further including an annular chamber within an annular array of hollow fiber membranes in fluid communication with the annular chamber extending from the impeller around the center pump housing; wherein the annular chamber provides substantially perpendicular radial outward cross flow across the membranes.

Abstract translation: 集成的血液泵充氧器包括支撑叶轮的叶轮壳体; 与环形水凝胶叶轮包装材料相邻的轴承和叶轮的轴周围。 所述充氧器包括围绕中心泵壳体构件延伸的环形室形式的翻转出口; 并且还包括在环形阵列的中空纤维膜内的环形室，其与从中心泵壳体周围的叶轮延伸的环形室流体连通; 其中所述环形室提供穿过所述膜的基本上垂直的径向向外横向流。