公开(公告)号：US10456227B2

公开(公告)日：2019-10-29

申请号：US15640873

申请日：2017-07-03

申请人： Ension, Inc.

发明人： Ali Hussain ,  Linda Cahalan ,  Greg Johnson ,  Mark Gartner ,  Patrick Cahalan ,  Brian J Fill ,  Jeffrey W. Speakman

IPC分类号： A61C15/04 ,  A61B17/06 ,  A61B17/064 ,  A61L31/04 ,  A61L31/10 ,  A61L33/00 ,  B05D3/06 ,  A61M1/16 ,  B05D7/02 ,  B05D1/36 ,  B05D1/00

摘要： A method of treating a tubular medical device with a biomolecule comprises the steps of: a) providing a polyolefin tubular substrate forming a tubular medical device; b) cleaning the tubular polyolefin substrate; c) exposing the tubular polyolefin substrate to a reactive gas containing at least one of acrylic acid and siloxane and to plasma energy to yield a plasma-deposited coating on at least one surface of the tubular polyolefin substrate; and d) attaching a biomolecule to the polyolefin substrate following formation of the plasma-deposited coating on at least one surface of the tubular polyolefin substrate, and wherein the biomolecule is at least one of an antibacterial agent, antimicrobial agent, anticoagulant, heparin, antithrombotic agent, platelet agent, anti-inflammatory, enzyme, catalyst, hormone, growth factor, drug, vitamin, antibody, antigen, protein, nucleic acid, dye, a DNA segment, an RNA segment, protein, and peptide.

公开(公告)号：US20180125620A1

公开(公告)日：2018-05-10

申请号：US15640873

申请日：2017-07-03

申请人： Ension, Inc.

发明人： Ali Hussain ,  Linda Cahalan ,  Greg Johnson ,  Mark Gartner ,  Patrick Cahalan ,  Brian J. Fill ,  Jeffrey W. Speakman

IPC分类号： A61C15/04 ,  A61L31/04 ,  A61B17/06

CPC分类号： A61C15/041 ,  A61B17/06 ,  A61B17/06166 ,  A61B17/064 ,  A61L31/048 ,  A61L31/10 ,  A61L33/0029 ,  A61L2400/18 ,  A61M1/1698 ,  B05D1/36 ,  B05D1/62 ,  B05D3/06 ,  B05D7/02 ,  B05D2256/00 ,  B05D2258/00 ,  C08L83/04 ,  C08L23/12

摘要： A method of treating a tubular medical device with a biomolecule comprises the steps of: a) providing a polyolefin tubular substrate forming a tubular medical device; b) cleaning the tubular polyolefin substrate; c) exposing the tubular polyolefin substrate to a reactive gas containing at least one of acrylic acid and siloxane and to plasma energy to yield a plasma-deposited coating on at least one surface of the tubular polyolefin substrate; and d) attaching a biomolecule to the polyolefin substrate following formation of the plasma-deposited coating on at least one surface of the tubular polyolefin substrate, and wherein the biomolecule is at least one of an antibacterial agent, antimicrobial agent, anticoagulant, heparin, antithrombotic agent, platelet agent, anti-inflammatory, enzyme, catalyst, hormone, growth factor, drug, vitamin, antibody, antigen, protein, nucleic acid, dye, a DNA segment, an RNA segment, protein, and peptide.

公开(公告)号：US20190125946A1

公开(公告)日：2019-05-02

申请号：US16220566

申请日：2018-12-14

申请人： Ension, Inc. ,  Massachusetts Institute of Technology

发明人： Mark Gartner ,  Minkyun Noh ,  David L. Trumper

IPC分类号： A61M1/10 ,  A61M1/36

摘要： A highly portable advanced adult and pediatric compact ECLS system is based around an integrated pump-oxygenator. The system includes a central a blood inlet and flow path extending along a general longitudinal axis of the system; a pump housing defining a pump inlet in fluid communication with the central blood flow path; an impeller rotationally received within the area of the pump inlet, wherein the impeller is magnetically supported and magnetically driven; an array of hollow fiber membranes configured for gas transfer within the system for oxygenation of blood flowing across the hollow fiber membranes, wherein the membranes include a covalently-bonded heparin-based bioactive surface, and wherein the blood flow path extends from the impeller to a position to flow perpendicular over the array of hollow fiber membranes; and a blood outlet configured to receive blood flowing past the array of hollow fiber membranes.

公开(公告)号：US11376413B2

公开(公告)日：2022-07-05

申请号：US16220566

申请日：2018-12-14

申请人： Ension, Inc. ,  Massachusetts Institute of Technology

发明人： Mark Gartner ,  Minkyun Noh ,  David L. Trumper

IPC分类号： A61M60/113 ,  A61M60/82 ,  A61M60/205 ,  A61M1/36 ,  A61M1/16

摘要： A highly portable advanced adult and pediatric compact ECLS system is based around an integrated pump-oxygenator. The system includes a central a blood inlet and flow path extending along a general longitudinal axis of the system; a pump housing defining a pump inlet in fluid communication with the central blood flow path; an impeller rotationally received within the area of the pump inlet, wherein the impeller is magnetically supported and magnetically driven; an array of hollow fiber membranes configured for gas transfer within the system for oxygenation of blood flowing across the hollow fiber membranes, wherein the membranes include a covalently-bonded heparin-based bioactive surface, and wherein the blood flow path extends from the impeller to a position to flow perpendicular over the array of hollow fiber membranes; and a blood outlet configured to receive blood flowing past the array of hollow fiber membranes.