公开(公告)号：US10744039B2

公开(公告)日：2020-08-18

申请号：US15790851

申请日：2017-10-23

申请人： Ension, Inc.

发明人： Ali Hussain ,  Patrick Cahalan ,  Linda Cahalan

IPC分类号： A61F13/00 ,  C07K14/78 ,  A61L15/32 ,  A61L15/42 ,  A61L27/20 ,  B32B5/10 ,  A61K38/39 ,  A61L27/24 ,  A61L31/14 ,  A61L31/04

摘要： A method of preparing a crosslinked, collagen-based wound care dressing is provided, comprising: (a) immersing a sample of fibrous and/or non-fibrous collagen in a buffered acidic, aqueous solution comprising an alcohol; (b) contacting the collagen in solution with a catalytic component comprising 1-ethyl-3-[3-dimethylaminopropyl]carbodiimide hydrochloride for a time at least sufficient to effect reaction between amino and carboxyl groups present on the collagen and to yield crosslinked collagen that is resistant to pronase degradation; and (c) drying the crosslinked collagen to yield a porous, crosslinked collagen article wherein the porous, crosslinked collagen article demonstrates a pore size of 10-500 microns. Also provided are bioactive collagen medical scaffolds for hernia repair prosthetics and surgical incision closure members, prepared using the method above.

公开(公告)号：US11622892B2

公开(公告)日：2023-04-11

申请号：US16995771

申请日：2020-08-17

申请人： Ension, Inc.

发明人： Ali Hussain ,  Patrick Cahalan ,  Linda Cahalan

IPC分类号： A61F13/00 ,  C07K14/78 ,  A61L15/32 ,  A61L15/42 ,  A61L27/20 ,  B32B5/10 ,  A61K38/39 ,  A61L27/24 ,  A61L31/14 ,  A61L31/04

摘要： A method of preparing a crosslinked, collagen-based wound care dressing is provided, comprising: (a) immersing a sample of fibrous and/or non-fibrous collagen in a buffered acidic, aqueous solution comprising an alcohol; (b) contacting the collagen in solution with a catalytic component comprising 1-ethyl-3-[3-dimethylaminopropyl]carbodiimide hydrochloride for a time at least sufficient to effect reaction between amino and carboxyl groups present on the collagen and to yield crosslinked collagen that is resistant to pronase degradation; and (c) drying the crosslinked collagen to yield a porous, crosslinked collagen article wherein the porous, crosslinked collagen article demonstrates a pore size of 10-500 microns. Also provided are bioactive collagen medical scaffolds for hernia repair prosthetics and surgical incision closure members, prepared using the method above.

公开(公告)号：US10456227B2

公开(公告)日：2019-10-29

申请号：US15640873

申请日：2017-07-03

申请人： Ension, Inc.

发明人： Ali Hussain ,  Linda Cahalan ,  Greg Johnson ,  Mark Gartner ,  Patrick Cahalan ,  Brian J Fill ,  Jeffrey W. Speakman

IPC分类号： A61C15/04 ,  A61B17/06 ,  A61B17/064 ,  A61L31/04 ,  A61L31/10 ,  A61L33/00 ,  B05D3/06 ,  A61M1/16 ,  B05D7/02 ,  B05D1/36 ,  B05D1/00

摘要： A method of treating a tubular medical device with a biomolecule comprises the steps of: a) providing a polyolefin tubular substrate forming a tubular medical device; b) cleaning the tubular polyolefin substrate; c) exposing the tubular polyolefin substrate to a reactive gas containing at least one of acrylic acid and siloxane and to plasma energy to yield a plasma-deposited coating on at least one surface of the tubular polyolefin substrate; and d) attaching a biomolecule to the polyolefin substrate following formation of the plasma-deposited coating on at least one surface of the tubular polyolefin substrate, and wherein the biomolecule is at least one of an antibacterial agent, antimicrobial agent, anticoagulant, heparin, antithrombotic agent, platelet agent, anti-inflammatory, enzyme, catalyst, hormone, growth factor, drug, vitamin, antibody, antigen, protein, nucleic acid, dye, a DNA segment, an RNA segment, protein, and peptide.

公开(公告)号：US09796769B2

公开(公告)日：2017-10-24

申请号：US14041372

申请日：2013-09-30

申请人： Ension, Inc.

发明人： Ali Hussain ,  Patrick Cahalan ,  Linda Cahalan

IPC分类号： C07K14/78 ,  A61L15/32 ,  A61L15/42 ,  A61L31/04 ,  A61L31/14

CPC分类号： C07K14/78 ,  A61L15/325 ,  A61L15/425 ,  A61L31/044 ,  A61L31/146

摘要： A method of preparing a crosslinked, collagen-based medical scaffold is provided, comprising: (a) immersing a sample of fibrous and/or non-fibrous collagen in a buffered acidic, aqueous solution comprising an alcohol; (b) contacting the collagen in solution with a catalytic component comprising 1-ethyl-3-[3-dimethylaminopropyl]carbodiimide hydrochloride for a time at least sufficient to effect reaction between amino and carboxyl groups present on the collagen and to yield crosslinked collagen that is resistant to pronase degradation; and (c) drying the crosslinked collagen to yield a porous, crosslinked collagen article wherein the porous, crosslinked collagen article demonstrates a pore size of 10-500 microns. Also provided are bioactive collagen medical scaffolds for wound care dressings, hernia repair prosthetics, and surgical incision closure members, prepared using the method above.

公开(公告)号：US20240159735A1

公开(公告)日：2024-05-16

申请号：US18535664

申请日：2023-12-11

申请人： Ension, Inc.

发明人： Patrick Cahalan ,  Linda Cahalan ,  Ali Hussain

IPC分类号： G01N33/50

CPC分类号： G01N33/50 ,  G01N2400/22 ,  G01N2400/40

摘要： A system and method of noise reduction in a blood panel testing comprising the steps of: drawing blood samples from a patient; and testing blood samples within a blood analyzer configured for noise reduction wherein the blood contacting surfaces of the blood panel testing platform have been activated and have been subsequently subject to wet chemistry treatment including enhancing the blood contacting surface of the blood analyzer with a wet chemistry treatment including an aqueous solution having a strong oxidizing agent; adding a positively charged spacer molecule to the blood contacting surface with a wet chemistry treatment including an aqueous solution having a cationic polymer; and covalently immobilizing heparin to the blood contacting surface of the blood analyzer with a wet chemistry treatment including heparin.

公开(公告)号：US20210100935A1

公开(公告)日：2021-04-08

申请号：US17074888

申请日：2020-10-20

申请人： Ension, Inc.

发明人： Ali Hussain ,  Linda Cahalan ,  Patrick Cahalan

IPC分类号： A61L33/08 ,  A61L33/00

摘要： A method of manufacturing a medical product having an engineered heparin bioactive matrix for clinical application on a blood contacting surface comprises: a) activating a blood contacting surface of at least one component of a medical device via one of plasma treatment or gas activation; b) assembling the medical product; c) Setting up medical device for wet chemistry in which wet chemistry treatments follows a blood flow path through device; d) enhancing at least the blood contacting surface with a wet chemistry treatment including an aqueous solution having a strong oxidizing agent, such as ammonium persulfate; e) adding a positively charged spacer molecule to at least the blood contacting surface with a wet chemistry treatment including an aqueous solution having a cationic polymer, such as PEI; and f) covalently immobilizing heparin to at least the blood contacting surface with a wet chemistry treatment including heparin, preferably deaminated heparin.

公开(公告)号：US20210007896A1

公开(公告)日：2021-01-14

申请号：US16995771

申请日：2020-08-17

申请人： Ension, Inc.

发明人： Ali Hussain ,  Patrick Cahalan ,  Linda Cahalan

IPC分类号： A61F13/00 ,  C07K14/78 ,  A61L15/32 ,  A61L15/42 ,  A61L27/20 ,  B32B5/10 ,  A61K38/39 ,  A61L27/24 ,  A61L31/14 ,  A61L31/04

摘要： A method of preparing a crosslinked, collagen-based wound care dressing is provided, comprising: (a) immersing a sample of fibrous and/or non-fibrous collagen in a buffered acidic, aqueous solution comprising an alcohol; (b) contacting the collagen in solution with a catalytic component comprising 1-ethyl-3-[3-dimethylaminopropyl]carbodiimide hydrochloride for a time at least sufficient to effect reaction between amino and carboxyl groups present on the collagen and to yield crosslinked collagen that is resistant to pronase degradation; and (c) drying the crosslinked collagen to yield a porous, crosslinked collagen article wherein the porous, crosslinked collagen article demonstrates a pore size of 10-500 microns. Also provided are bioactive collagen medical scaffolds for hernia repair prosthetics and surgical incision closure members, prepared using the method above.

公开(公告)号：US20180125620A1

公开(公告)日：2018-05-10

申请号：US15640873

申请日：2017-07-03

申请人： Ension, Inc.

发明人： Ali Hussain ,  Linda Cahalan ,  Greg Johnson ,  Mark Gartner ,  Patrick Cahalan ,  Brian J. Fill ,  Jeffrey W. Speakman

IPC分类号： A61C15/04 ,  A61L31/04 ,  A61B17/06

CPC分类号： A61C15/041 ,  A61B17/06 ,  A61B17/06166 ,  A61B17/064 ,  A61L31/048 ,  A61L31/10 ,  A61L33/0029 ,  A61L2400/18 ,  A61M1/1698 ,  B05D1/36 ,  B05D1/62 ,  B05D3/06 ,  B05D7/02 ,  B05D2256/00 ,  B05D2258/00 ,  C08L83/04 ,  C08L23/12

摘要： A method of treating a tubular medical device with a biomolecule comprises the steps of: a) providing a polyolefin tubular substrate forming a tubular medical device; b) cleaning the tubular polyolefin substrate; c) exposing the tubular polyolefin substrate to a reactive gas containing at least one of acrylic acid and siloxane and to plasma energy to yield a plasma-deposited coating on at least one surface of the tubular polyolefin substrate; and d) attaching a biomolecule to the polyolefin substrate following formation of the plasma-deposited coating on at least one surface of the tubular polyolefin substrate, and wherein the biomolecule is at least one of an antibacterial agent, antimicrobial agent, anticoagulant, heparin, antithrombotic agent, platelet agent, anti-inflammatory, enzyme, catalyst, hormone, growth factor, drug, vitamin, antibody, antigen, protein, nucleic acid, dye, a DNA segment, an RNA segment, protein, and peptide.