公开(公告)号：US20210198277A1

公开(公告)日：2021-07-01

申请号：US17100489

申请日：2020-11-20

Applicant: Epizyme, Inc.

Inventor： John Emmerson CAMPBELL ,  Kenneth William DUNCAN ,  Megan Alene FOLEY ,  Darren Martin HARVEY ,  Kevin Wayne KUNTZ ,  James Edward John MILLS ,  Michael John MUNCHHOF

IPC: C07D498/04 ,  C07D401/12 ,  C07D239/48 ,  C07D231/38 ,  C07D213/74 ,  C07D215/38 ,  C07D239/49 ,  C07D401/14 ,  C07D403/12 ,  C07D403/14 ,  C07D405/12 ,  C07D405/14 ,  C07D409/14 ,  C07D413/12 ,  C07D413/14 ,  C07D471/04 ,  C07D473/32 ,  C07D487/04 ,  C07D491/044

Abstract: The present disclosure relates to amine-substituted aryl or heteroaryl compounds. The present disclosure also relates to pharmaceutical compositions containing these compounds and methods of treating a disorder (e.g., sickle cell anemia) via inhibition of a methyltransferase enzyme selected from EHMT1 and EHMT2, by administering an amine-substituted aryl or heteroaryl compound disclosed herein or a pharmaceutical composition thereof to subjects in need thereof. The present disclosure also relates to the use of such compounds for research or other non-therapeutic purposes.