公开(公告)号：US20220235065A1

公开(公告)日：2022-07-28

申请号：US17526058

申请日：2021-11-15

Applicant: Epizyme, Inc.

Inventor： John Emmerson CAMPBELL ,  Kenneth William DUNCAN

IPC: C07D491/14 ,  C07D403/12 ,  C07D403/14 ,  C07D405/14 ,  C07D413/12 ,  C07D471/04 ,  C07D487/04 ,  C07D491/04 ,  C07D491/107 ,  C07D498/04

Abstract: The present disclosure relates to amine-substituted heterocyclic compounds. The present disclosure also relates to pharmaceutical compositions containing these compounds and methods of treating a disorder (e.g., cancer) via inhibition of a methyltransferase enzyme selected from EHMT1 and EHMT2, by administering an amine-substituted heterocyclic heterocyclic compound disclosed herein or a pharmaceutical composition thereof to subjects in need thereof. The present disclosure also relates to the use of such compounds for research or other non-therapeutic purposes.

公开(公告)号：US20230364086A1

公开(公告)日：2023-11-16

申请号：US18188691

申请日：2023-03-23

Applicant: Epizyme, Inc.

Inventor： John Emmerson CAMPBELL ,  Kenneth William DUNCAN ,  Maria Alejandra RAIMONDI ,  Christine KLAUS ,  Elayne PENEBRE

IPC: A61K31/506 ,  A61P35/00 ,  A61K31/203 ,  A61K31/4375 ,  A61K31/44 ,  A61K31/496 ,  A61K31/517 ,  A61K31/519 ,  A61K31/706

CPC classification number: A61K31/506 ,  A61P35/00 ,  A61K31/203 ,  A61K31/4375 ,  A61K31/44 ,  A61K31/496 ,  A61K31/517 ,  A61K31/519 ,  A61K31/706

Abstract: The present disclosure relates to a method of preventing or treating a cancer via administering an EHMT2 inhibitor or a combination comprising an EHMT2 inhibitor compound and one or more additional therapeutic agent disclosed herein or a pharmaceutical composition thereof to subjects in need thereof. The present disclosure also relates to the use of such compounds or combinations for research or other non-therapeutic purposes.

公开(公告)号：US20200247790A1

公开(公告)日：2020-08-06

申请号：US16756565

申请日：2018-10-18

Applicant: Epizyme, Inc.

Inventor： John Emmerson CAMPBELL ,  Kenneth William DUNCAN ,  James Edward John MILLS ,  Michael John MUNCHHOF

IPC: C07D405/14 ,  C07D401/14 ,  C07D403/12

Abstract: The present disclosure relates to amine-substituted heterocyclic compounds. The present disclosure also relates to pharmaceutical compositions containing these compounds and methods of treating a disorder (e.g., cancer) by administering an amine-substituted heterocyclic compound disclosed herein or a pharmaceutical composition thereof to subjects in need thereof. The present disclosure also relates to the use of such compounds for research or other non-therapeutic purposes.

公开(公告)号：US20200039961A1

公开(公告)日：2020-02-06

申请号：US16338093

申请日：2017-09-29

Applicant: Epizyme, Inc.

Inventor： John Emmerson CAMPBELL ,  Kenneth William DUNCAN

IPC: C07D403/12 ,  C07D491/107 ,  C07D417/12 ,  C07D405/14 ,  C07D401/06 ,  C07D471/04 ,  C07D487/04 ,  C07D209/40 ,  C07D413/12 ,  C07D235/30

Abstract: The present disclosure relates to substituted fused bi- or tri-heterocyclic compounds. The present disclosure also relates to pharmaceutical compositions containing these compounds and methods of treating a disorder (e.g., sickle cell anemia) via inhibition of a methyltransferase enzyme selected from EHMT1 and EHMT2, by administering a substituted fused bi- or tri-heterocyclic compound disclosed herein or a pharmaceutical composition thereof to subjects in need thereof. The present disclosure also relates to the use of such compounds for research or other non-therapeutic purposes.

公开(公告)号：US20230087806A1

公开(公告)日：2023-03-23

申请号：US17474581

申请日：2021-09-14

Applicant: Epizyme, Inc.

Inventor： John Emmerson CAMPBELL ,  Kenneth William DUNCAN ,  Elayne PENEBRE ,  Kat COSMOPOULOS ,  Christine KLAUS

IPC: A61K31/506 ,  A61K31/4155 ,  A61K31/416 ,  A61K31/4184 ,  A61K31/437 ,  A61K31/4439 ,  A61K31/444 ,  A61K31/4545 ,  A61K31/501 ,  A61K31/505 ,  A61K31/519 ,  A61K31/5377 ,  A61K31/551 ,  A61K31/5513 ,  A61K31/553 ,  A61K45/06

Abstract: The present disclosure relates to a method of preventing or treating an imprinting disorder via administering an EHMT2 inhibitor compound disclosed herein or a pharmaceutical composition thereof to subjects in need thereof. The present disclosure also relates to the use of such compounds for research or other non-therapeutic purposes.

公开(公告)号：US20220324851A1

公开(公告)日：2022-10-13

申请号：US17703155

申请日：2022-03-24

Applicant: Epizyme, Inc.

Inventor： John Emmerson CAMPBELL ,  Kenneth William DUNCAN ,  James Edward John MILLS ,  Michael John MUNCHHOF

IPC: C07D405/14 ,  C07D401/14 ,  C07D403/12

Abstract: The present disclosure relates to amine-substituted heterocyclic compounds. The present disclosure also relates to pharmaceutical compositions containing these compounds and methods of treating a disorder (e.g., cancer) by administering an amine-substituted heterocyclic heterocyclic compound disclosed herein or a pharmaceutical composition thereof to subjects in need thereof. The present disclosure also relates to the use of such compounds for research or other non-therapeutic purposes.

公开(公告)号：US20200317642A1

公开(公告)日：2020-10-08

申请号：US16756292

申请日：2018-10-17

Applicant: Epizyme, Inc.

Inventor： John Emmerson CAMPBELL ,  Kenneth William DUNCAN ,  James Edward John MILLS ,  Michael John MUNCHHOF

IPC: C07D401/12 ,  C07D403/14 ,  C07D471/04 ,  C07D403/04 ,  C07D403/12 ,  C07D413/12 ,  C07D487/04 ,  A61P7/06

Abstract: The present disclosure relates to amine-substituted heterocyclic compounds and derivatives thereof. The present disclosure also relates to pharmaceutical compositions containing these compounds and methods of treating a disorder (e.g., cancer) by administering an amine-substituted heterocyclic compound disclosed herein or a pharmaceutical composition thereof to subjects in need thereof. The present disclosure also relates to the use of such compounds for research or other non-therapeutic purposes.

公开(公告)号：US20200039998A1

公开(公告)日：2020-02-06

申请号：US16471151

申请日：2017-12-19

Applicant: Epizyme, Inc.

Inventor： John Emmerson CAMPBELL ,  Kenneth William DUNCAN

IPC: C07D491/14 ,  C07D491/04 ,  C07D491/107 ,  C07D498/04 ,  C07D487/04 ,  C07D471/04 ,  C07D403/14 ,  C07D413/12 ,  C07D403/12 ,  C07D405/14

Abstract: The present disclosure relates to amine-substituted heterocyclic compounds. The present disclosure also relates to pharmaceutical compositions containing these compounds and methods of treating a disorder (e.g., cancer) via inhibition of a methyltransferase enzyme selected from EHMT1 and EHMT2, by administering an amine-substituted heterocyclic compound disclosed herein or a pharmaceutical composition thereof to subjects in need thereof. The present disclosure also relates to the use of such compounds for research or other non-therapeutic purposes.

公开(公告)号：US20220274961A1

公开(公告)日：2022-09-01

申请号：US17560545

申请日：2021-12-23

Applicant: Epizyme, Inc.

Inventor： John Emmerson CAMPBELL ,  Kenneth William DUNCAN

IPC: C07D403/12 ,  C07D209/40 ,  C07D235/30 ,  C07D401/06 ,  C07D405/14 ,  C07D413/12 ,  C07D417/12 ,  C07D471/04 ,  C07D487/04 ,  C07D491/107

Abstract: The present disclosure relates to substituted fused bi- or tri-heterocyclic compounds. The present disclosure also relates to pharmaceutical compositions containing these compounds and methods of treating a disorder (e.g., sickle cell anemia) via inhibition of a methyltransferase enzyme selected from EHMT1 and EHMT2, by administering a substituted fused bi- or tri-heterocyclic compound disclosed herein or a pharmaceutical composition thereof to subjects in need thereof. The present disclosure also relates to the use of such compounds for research or other non-therapeutic purposes.

公开(公告)号：US20210198277A1

公开(公告)日：2021-07-01

申请号：US17100489

申请日：2020-11-20

Applicant: Epizyme, Inc.

Inventor： John Emmerson CAMPBELL ,  Kenneth William DUNCAN ,  Megan Alene FOLEY ,  Darren Martin HARVEY ,  Kevin Wayne KUNTZ ,  James Edward John MILLS ,  Michael John MUNCHHOF

IPC: C07D498/04 ,  C07D401/12 ,  C07D239/48 ,  C07D231/38 ,  C07D213/74 ,  C07D215/38 ,  C07D239/49 ,  C07D401/14 ,  C07D403/12 ,  C07D403/14 ,  C07D405/12 ,  C07D405/14 ,  C07D409/14 ,  C07D413/12 ,  C07D413/14 ,  C07D471/04 ,  C07D473/32 ,  C07D487/04 ,  C07D491/044

Abstract: The present disclosure relates to amine-substituted aryl or heteroaryl compounds. The present disclosure also relates to pharmaceutical compositions containing these compounds and methods of treating a disorder (e.g., sickle cell anemia) via inhibition of a methyltransferase enzyme selected from EHMT1 and EHMT2, by administering an amine-substituted aryl or heteroaryl compound disclosed herein or a pharmaceutical composition thereof to subjects in need thereof. The present disclosure also relates to the use of such compounds for research or other non-therapeutic purposes.