公开(公告)号：US20230364086A1

公开(公告)日：2023-11-16

申请号：US18188691

申请日：2023-03-23

Applicant: Epizyme, Inc.

Inventor： John Emmerson CAMPBELL ,  Kenneth William DUNCAN ,  Maria Alejandra RAIMONDI ,  Christine KLAUS ,  Elayne PENEBRE

IPC: A61K31/506 ,  A61P35/00 ,  A61K31/203 ,  A61K31/4375 ,  A61K31/44 ,  A61K31/496 ,  A61K31/517 ,  A61K31/519 ,  A61K31/706

CPC classification number: A61K31/506 ,  A61P35/00 ,  A61K31/203 ,  A61K31/4375 ,  A61K31/44 ,  A61K31/496 ,  A61K31/517 ,  A61K31/519 ,  A61K31/706

Abstract: The present disclosure relates to a method of preventing or treating a cancer via administering an EHMT2 inhibitor or a combination comprising an EHMT2 inhibitor compound and one or more additional therapeutic agent disclosed herein or a pharmaceutical composition thereof to subjects in need thereof. The present disclosure also relates to the use of such compounds or combinations for research or other non-therapeutic purposes.

公开(公告)号：US20180208591A1

公开(公告)日：2018-07-26

申请号：US15693680

申请日：2017-09-01

Applicant: Epizyme, Inc.

Inventor： John Emmerson CAMPBELL ,  Kevin W. KUNTZ

IPC: C07D471/04 ,  C07D231/56

CPC classification number: C07D471/04 ,  C07D231/56

Abstract: The present invention relates to azole bicyclic heteroaryl compounds. The present invention also relates to pharmaceutical compositions containing these compounds and methods of treating cancer by administering these compounds and pharmaceutical compositions to subjects in need thereof. The present invention also relates to the use of such compounds for research or other non-therapeutic purposes.

公开(公告)号：US20170217941A1

公开(公告)日：2017-08-03

申请号：US15321256

申请日：2015-06-25

Applicant: Epizyme, Inc.

Inventor： John Emmerson CAMPBELL

IPC: C07D405/14 ,  C07D231/20 ,  C07D211/58 ,  C07D401/12 ,  C07D403/12 ,  C07D401/14 ,  C07D213/68 ,  C07D213/64

CPC classification number: C07D405/14 ,  C07D211/58 ,  C07D213/64 ,  C07D213/68 ,  C07D231/20 ,  C07D401/12 ,  C07D401/14 ,  C07D403/12

Abstract: The present invention relates to substituted benzene compounds and bicyclic heteroaryl compounds. The present invention also relates to pharmaceutical compositions containing these compounds and methods of treating cancer by administering these compounds and pharmaceutical compositions to subjects in need thereof. The present invention also relates to the use of such compounds for research or other non-therapeutic purposes.

公开(公告)号：US20220235065A1

公开(公告)日：2022-07-28

申请号：US17526058

申请日：2021-11-15

Applicant: Epizyme, Inc.

Inventor： John Emmerson CAMPBELL ,  Kenneth William DUNCAN

IPC: C07D491/14 ,  C07D403/12 ,  C07D403/14 ,  C07D405/14 ,  C07D413/12 ,  C07D471/04 ,  C07D487/04 ,  C07D491/04 ,  C07D491/107 ,  C07D498/04

Abstract: The present disclosure relates to amine-substituted heterocyclic compounds. The present disclosure also relates to pharmaceutical compositions containing these compounds and methods of treating a disorder (e.g., cancer) via inhibition of a methyltransferase enzyme selected from EHMT1 and EHMT2, by administering an amine-substituted heterocyclic heterocyclic compound disclosed herein or a pharmaceutical composition thereof to subjects in need thereof. The present disclosure also relates to the use of such compounds for research or other non-therapeutic purposes.

公开(公告)号：US20190060322A1

公开(公告)日：2019-02-28

申请号：US16120702

申请日：2018-09-04

Applicant: Epizyme, Inc.

Inventor： Kevin Wayne KUNTZ ,  John Emmerson CAMPBELL ,  Masashi SEKI ,  Syuji SHIROTORI ,  Wataru ITANO ,  Wanjun ZHENG

IPC: A61K31/5377 ,  C07D405/12 ,  C07D401/12 ,  A61K31/4545 ,  C07D405/14 ,  A61K31/5375 ,  C07D213/64 ,  A61K31/4412

Abstract: The present invention relates to substituted benzene compounds. The present invention also relates to pharmaceutical compositions containing these compounds and methods of treating cancer by administering these compounds and pharmaceutical compositions to subjects in need thereof. The present invention also relates to the use of such compounds for research or other non-therapeutic purposes.

公开(公告)号：US20200247790A1

公开(公告)日：2020-08-06

申请号：US16756565

申请日：2018-10-18

Applicant: Epizyme, Inc.

Inventor： John Emmerson CAMPBELL ,  Kenneth William DUNCAN ,  James Edward John MILLS ,  Michael John MUNCHHOF

IPC: C07D405/14 ,  C07D401/14 ,  C07D403/12

Abstract: The present disclosure relates to amine-substituted heterocyclic compounds. The present disclosure also relates to pharmaceutical compositions containing these compounds and methods of treating a disorder (e.g., cancer) by administering an amine-substituted heterocyclic compound disclosed herein or a pharmaceutical composition thereof to subjects in need thereof. The present disclosure also relates to the use of such compounds for research or other non-therapeutic purposes.

公开(公告)号：US20200039961A1

公开(公告)日：2020-02-06

申请号：US16338093

申请日：2017-09-29

Applicant: Epizyme, Inc.

Inventor： John Emmerson CAMPBELL ,  Kenneth William DUNCAN

IPC: C07D403/12 ,  C07D491/107 ,  C07D417/12 ,  C07D405/14 ,  C07D401/06 ,  C07D471/04 ,  C07D487/04 ,  C07D209/40 ,  C07D413/12 ,  C07D235/30

Abstract: The present disclosure relates to substituted fused bi- or tri-heterocyclic compounds. The present disclosure also relates to pharmaceutical compositions containing these compounds and methods of treating a disorder (e.g., sickle cell anemia) via inhibition of a methyltransferase enzyme selected from EHMT1 and EHMT2, by administering a substituted fused bi- or tri-heterocyclic compound disclosed herein or a pharmaceutical composition thereof to subjects in need thereof. The present disclosure also relates to the use of such compounds for research or other non-therapeutic purposes.

公开(公告)号：US20230087806A1

公开(公告)日：2023-03-23

申请号：US17474581

申请日：2021-09-14

Applicant: Epizyme, Inc.

Inventor： John Emmerson CAMPBELL ,  Kenneth William DUNCAN ,  Elayne PENEBRE ,  Kat COSMOPOULOS ,  Christine KLAUS

IPC: A61K31/506 ,  A61K31/4155 ,  A61K31/416 ,  A61K31/4184 ,  A61K31/437 ,  A61K31/4439 ,  A61K31/444 ,  A61K31/4545 ,  A61K31/501 ,  A61K31/505 ,  A61K31/519 ,  A61K31/5377 ,  A61K31/551 ,  A61K31/5513 ,  A61K31/553 ,  A61K45/06

Abstract: The present disclosure relates to a method of preventing or treating an imprinting disorder via administering an EHMT2 inhibitor compound disclosed herein or a pharmaceutical composition thereof to subjects in need thereof. The present disclosure also relates to the use of such compounds for research or other non-therapeutic purposes.

公开(公告)号：US20220324851A1

公开(公告)日：2022-10-13

申请号：US17703155

申请日：2022-03-24

Applicant: Epizyme, Inc.

Inventor： John Emmerson CAMPBELL ,  Kenneth William DUNCAN ,  James Edward John MILLS ,  Michael John MUNCHHOF

IPC: C07D405/14 ,  C07D401/14 ,  C07D403/12

Abstract: The present disclosure relates to amine-substituted heterocyclic compounds. The present disclosure also relates to pharmaceutical compositions containing these compounds and methods of treating a disorder (e.g., cancer) by administering an amine-substituted heterocyclic heterocyclic compound disclosed herein or a pharmaceutical composition thereof to subjects in need thereof. The present disclosure also relates to the use of such compounds for research or other non-therapeutic purposes.

公开(公告)号：US20200317642A1

公开(公告)日：2020-10-08

申请号：US16756292

申请日：2018-10-17

Applicant: Epizyme, Inc.

Inventor： John Emmerson CAMPBELL ,  Kenneth William DUNCAN ,  James Edward John MILLS ,  Michael John MUNCHHOF

IPC: C07D401/12 ,  C07D403/14 ,  C07D471/04 ,  C07D403/04 ,  C07D403/12 ,  C07D413/12 ,  C07D487/04 ,  A61P7/06

Abstract: The present disclosure relates to amine-substituted heterocyclic compounds and derivatives thereof. The present disclosure also relates to pharmaceutical compositions containing these compounds and methods of treating a disorder (e.g., cancer) by administering an amine-substituted heterocyclic compound disclosed herein or a pharmaceutical composition thereof to subjects in need thereof. The present disclosure also relates to the use of such compounds for research or other non-therapeutic purposes.