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公开(公告)号：US10245269B2
公开(公告)日：2019-04-02
申请号：US15837390
申请日：2017-12-11
发明人： Kevin Wayne Kuntz , Kuan-Chun Huang , Hyeong Wook Choi , Kristen Sanders , Steven Mathieu , Arani Chanda , Francis Fang
IPC分类号： A61K31/5377 , C07D405/12
摘要： Provided herein is N-((4,6-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)methyl)-5-(ethyl (tetrahydro-2H-pyran-4-yl)amino)-4-methyl-4′-(morpholinomethyl)-[1,1′-biphenyl]-3-carboxamide hydrobromide. Also provided herein is a particular polymorph form of this compound.
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公开(公告)号：US20180243316A1
公开(公告)日：2018-08-30
申请号：US15837390
申请日：2017-12-11
发明人： Kevin Wayne Kuntz , Kuan-Chun Huang , Hyeong Wook Choi , Kristen Sanders , Steven Mathieu , Arani Chanda , Francis Fang
IPC分类号： A61K31/5377
CPC分类号： A61K31/5377 , C07D405/12 , Y02A50/401 , Y02A50/409 , Y02A50/411
摘要： Provided herein is N-((4,6-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)methyl)-5-(ethyl (tetrahydro-2H-pyran-4-yl)amino)-4-methyl-4′-(morpholinomethyl)-[1,1′-biphenyl]-3-carboxamide hydrobromide. Also provided herein is a particular polymorph form of this compound.
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公开(公告)号：US20150065503A1
公开(公告)日：2015-03-05
申请号：US14394431
申请日：2013-04-11
发明人： Kevin Wayne Kuntz , Kuan-chun Huang , Hyeong wook Choi , Kristen Sanders , Steven Mathieu , Arani Chanda , Frank Fang
IPC分类号： C07D405/12
CPC分类号： A61K31/5377 , C07D405/12
摘要： Provided herein is N-((4,6-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)methyl)-5-(ethyl(tetrahydro-2H-pyran-4-yl)amino)-4-methyl-4′-(morpholinomethyl)-[1,1′-biphenyl]-3-carboxamide hydrobromide. Also provided herein is a particular polymorph form of this compound.
摘要翻译： 本文提供的是N - （（4,6-二甲基-2-氧代-1,2-二氢吡啶-3-基）甲基）-5-（乙基（四氢-2H-吡喃-4-基）氨基）-4- 甲基-4' - （吗啉代甲基） - [1,1'-联苯] -3-甲酰胺氢溴酸盐。 本文还提供了该化合物的特定多晶型物。
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公开(公告)号：US11491163B2
公开(公告)日：2022-11-08
申请号：US17032432
申请日：2020-09-25
发明人： Kevin Wayne Kuntz , Kuan-Chun Huang , Hyeong Wook Choi , Kristen Sanders , Steven Mathieu , Arani Chanda , Francis Fang
IPC分类号： A61K31/5377 , C07D405/12
摘要： Provided herein is N-((4,6-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)methyl)-5-(ethyl (tetrahydro-2H-pyran-4-yl)amino)-4-methyl-4′-(morpholinomethyl)-[1,1′-biphenyl]-3-carboxamide hydrobromide. Also provided herein is a particular polymorph form of this compound.
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公开(公告)号：US10821113B2
公开(公告)日：2020-11-03
申请号：US16270752
申请日：2019-02-08
发明人： Kevin Wayne Kuntz , Kuan-Chun Huang , Hyeong Wook Choi , Kristen Sanders , Steven Mathieu , Arani Chanda , Francis Fang
IPC分类号： A61K31/5377 , C07D405/12
摘要： Provided herein is N-((4,6-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)methyl)-5-(ethyl (tetrahydro-2H-pyran-4-yl)amino)-4-methyl-4′-(morpholinomethyl)-[1,1′-biphenyl]-3-carboxamide hydrobromide. Also provided herein is a particular polymorph form of this compound.
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公开(公告)号：US20230140327A1
公开(公告)日：2023-05-04
申请号：US17936555
申请日：2022-09-29
发明人： Kevin Wayne KUNTZ , Kuan-Chun Huang , Hyeong Wook Choi , Kristen Sanders , Steven Mathieu , Arani Chanda , Francis Fang
IPC分类号： A61K31/5377 , C07D405/12
摘要： Provided herein is N-((4,6-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)methyl)-5-(ethyl (tetrahydro-2H-pyran-4-yl)amino)-4-methyl-4′-(morpholinomethyl)-[1,1′-biphenyl]-3-carboxamide hydrobromide. Also provided herein is a particular polymorph form of this compound.
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公开(公告)号：US10040782B2
公开(公告)日：2018-08-07
申请号：US15029848
申请日：2014-10-15
IPC分类号： C07D405/12 , A61K31/5377 , C07D413/12
摘要： Provided herein are novel solid forms of N-((4,6-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)methyl)-5-(ethyl(tetrahydro-2H-pyran-4-yl)amino)-4-methyl-4′-(morpholinomethyl)-[1,1′-biphenyl]-3-carboxamide hydrochloride, and related compositions and methods.
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公开(公告)号：US10710987B2
公开(公告)日：2020-07-14
申请号：US16000539
申请日：2018-06-05
IPC分类号： C07D405/12 , A61K31/5377 , C07D413/12
摘要： Provided herein are novel solid forms of N-((4,6-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)methyl)-5-(ethyl (tetrahydro-2H-pyran-4-yl)amino)-4-methyl-4′-(morpholinomethyl)-[1,1′-biphenyl]-3-carboxamide hydrochloride, and related compositions and methods.
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公开(公告)号：US09872862B2
公开(公告)日：2018-01-23
申请号：US15199522
申请日：2016-06-30
发明人： Kevin Wayne Kuntz , Kuan-Chun Huang , Hyeong Wook Choi , Kristen Sanders , Steven Mathieu , Arani Chanda , Frances Fang
IPC分类号： A61K31/5377
CPC分类号： A61K31/5377 , C07D405/12
摘要： Provided herein is N-((4,6-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)methyl)-5-(ethyl (tetrahydro-2H-pyran-4-yl)amino)-4-methyl-4′-(morpholinomethyl)-[1,1′-biphenyl]-3-carboxamide hydrobromide. Also provided herein is a particular polymorph form of this compound.
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公开(公告)号：US09394283B2
公开(公告)日：2016-07-19
申请号：US14394431
申请日：2013-04-11
发明人： Kevin Wayne Kuntz , Kuan-Chun Huang , Hyeong Wook Choi , Kristen Sanders , Steven Mathieu , Arani Chanda , Frances Fang
IPC分类号： C07D405/12
CPC分类号： A61K31/5377 , C07D405/12
摘要： Provided herein is N-((4,6-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)methyl)-5-(ethyl(tetrahydro-2H-pyran-4-yl)amino)-4-methyl-4′-(morpholinomethyl)-[1,1′-biphenyl]-3-carboxamide hydrobromide. Also provided herein is a particular polymorph form of this compound.
摘要翻译： 本文提供的是N - （（4,6-二甲基-2-氧代-1,2-二氢吡啶-3-基）甲基）-5-（乙基（四氢-2H-吡喃-4-基）氨基）-4- 甲基-4' - （吗啉代甲基） - [1,1'-联苯] -3-甲酰胺氢溴酸盐。 本文还提供了该化合物的特定多晶型物。
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