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公开(公告)号：US10040782B2
公开(公告)日：2018-08-07
申请号：US15029848
申请日：2014-10-15
IPC分类号： C07D405/12 , A61K31/5377 , C07D413/12
摘要： Provided herein are novel solid forms of N-((4,6-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)methyl)-5-(ethyl(tetrahydro-2H-pyran-4-yl)amino)-4-methyl-4′-(morpholinomethyl)-[1,1′-biphenyl]-3-carboxamide hydrochloride, and related compositions and methods.
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公开(公告)号：US20190315754A1
公开(公告)日：2019-10-17
申请号：US16391882
申请日：2019-04-23
发明人： Wanjun Zheng , Xiaojie Zhu , Hong Du , Maarten Postema , Yimin Jiang , Jing Li , Robert Yu , Hyeong-wook Choi , Jaemoon Lee , Frank Fang , Daniel Custar
IPC分类号： C07D487/04 , C07D519/00 , A61P35/00
摘要： We provide compounds given by Formula I, which is shown in FIG. 3, or pharmaceutically acceptable salts thereof, as well as formulations thereof and methods of use of those compounds and formulations for treatment of cancer.
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公开(公告)号：US10941148B2
公开(公告)日：2021-03-09
申请号：US16391882
申请日：2019-04-23
发明人： Wanjun Zheng , Xiaojie Zhu , Hong Du , Maarten Postema , Yimin Jiang , Jing Li , Robert Yu , Hyeong-wook Choi , Jaemoon Lee , Frank Fang , Daniel Custar
IPC分类号： C07D487/04 , C07D519/00 , A61P35/00
摘要： We provide compounds given by Formula I, which is shown in FIG. 3, or pharmaceutically acceptable salts thereof, as well as formulations thereof and methods of use of those compounds and formulations for treatment of cancer.
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公开(公告)号：US20180305362A1
公开(公告)日：2018-10-25
申请号：US15768668
申请日：2016-10-14
发明人： Wanjun Zheng , Xiaojie Zhu , Hong Du , Maarten Postema , Yimin Jiang , Jing Li , Robert Yu , Hyeong-wook Choi , Jaemoon Lee , Frank Fang , Daniel Custar
IPC分类号： C07D487/04 , C07D519/00 , A61P35/00
CPC分类号： C07D487/04 , A61P35/00 , C07D519/00
摘要： We provide compounds given by Formula I, which is shown in FIG. 3, or pharmaceutically acceptable salts thereof, as well as formulations thereof and methods of use of those compounds and formulations for treatment of cancer.
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公开(公告)号：US10316040B2
公开(公告)日：2019-06-11
申请号：US15768668
申请日：2016-10-14
发明人： Wanjun Zheng , Xiaojie Zhu , Hong Du , Maarten Postema , Yimin Jiang , Jing Li , Robert Yu , Hyeong-wook Choi , Jaemoon Lee , Frank Fang , Daniel Custar
IPC分类号： C07D487/04 , C07D519/00 , A61P35/00
摘要： We provide compounds given by Formula I, which is shown in FIG. 3, or pharmaceutically acceptable salts thereof, as well as formulations thereof and methods of use of those compounds and formulations for treatment of cancer.
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公开(公告)号：US11339188B2
公开(公告)日：2022-05-24
申请号：US16781352
申请日：2020-02-04
发明人： Dae-Shik Kim , Frank Fang , Atsushi Endo , Hyeong-wook Choi , Ming-Hong Hao , Xingfeng Bao , Kuan-Chun Huang
IPC分类号： C07H21/02 , A61P35/02 , A61K31/7084 , C07F9/6587 , C07H21/00 , A61P31/04 , A61P37/04
摘要： Provided herein are compounds useful for the treatment of cancer.
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公开(公告)号：US10793581B2
公开(公告)日：2020-10-06
申请号：US16521691
申请日：2019-07-25
IPC分类号： C07D493/22 , C07B57/00 , C07D313/00 , C07D493/08 , C07D493/18
摘要： The present invention relates to stereochemically defined polypropionates and methods for preparing and using the same. The stereochemically defined polypropionates may be useful in the synthesis of natural products and/or natural product-like libraries.
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