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公开(公告)号:US07247337B1
公开(公告)日:2007-07-24
申请号:US10322280
申请日:2002-12-16
CPC分类号: B82Y30/00 , B01J19/0046 , B01J2219/00378 , B01J2219/00387 , B01J2219/00497 , B01J2219/00527 , B01J2219/00547 , B01J2219/00585 , B01J2219/00596 , B01J2219/00605 , B01J2219/0061 , B01J2219/00612 , B01J2219/00626 , B01J2219/00637 , B01J2219/00659 , B01J2219/00662 , B01J2219/00675 , B01J2219/00677 , B01J2219/00722 , B01J2219/00725 , B01J2219/00731
摘要: The invention provides a method and apparatus for micro array fabrication exclusive from the impact of a gas. A housing with a gas free chamber provides for improved micro array fabrication with a lower defect rate. The invention provides a housing that excludes a gas such as ozone to prevent interaction with probe construction or attachment. A method of fabricating a micro array in an ozone free environment is also disclosed.
摘要翻译: 本发明提供一种排除气体影响的微阵列制造方法和装置。 具有无气室的壳体提供具有较低缺陷率的改进的微阵列制造。 本发明提供一种不包括诸如臭氧的气体以防止与探针结构或附着相互作用的壳体。 还公开了一种在无臭氧环境中制造微阵列的方法。
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公开(公告)号:US07435810B2
公开(公告)日:2008-10-14
申请号:US11020428
申请日:2004-12-22
CPC分类号: B82Y30/00 , B01J2219/00378 , B01J2219/00608 , B01J2219/00612 , B01J2219/00626 , B01J2219/00675 , B01J2219/00677 , C07B2200/11 , C07H21/00 , C40B50/14 , C40B60/14 , Y02P20/542
摘要: A method of fabricating polynucleotide arrays includes dissolving a nucleotide monomer, oligonucleotide, or polynucleotide in a solvent containing ionic liquid and depositing the resulting solution on an array substrate. The method has particular application to fabrication of an addressable array of polynucleotides on a substrate that carries substrate bound moieties each with a hydroxyl group. The process may be repeated at specific locations on the array to elongate the polynucleotide deposited on the array.
摘要翻译: 制备多核苷酸阵列的方法包括将核苷酸单体,寡核苷酸或多核苷酸溶解在含有离子液体的溶剂中,并将所得溶液沉积在阵列基底上。 该方法特别适用于在载体上具有羟基的底物结合部分的底物上制造多核苷酸可寻址阵列。 该过程可以在阵列上的特定位置重复以延长沉积在阵列上的多核苷酸。
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公开(公告)号:US06852850B2
公开(公告)日:2005-02-08
申请号:US10001044
申请日:2001-10-31
CPC分类号: B82Y30/00 , B01J2219/00378 , B01J2219/00608 , B01J2219/00612 , B01J2219/00626 , B01J2219/00675 , B01J2219/00677 , C07B2200/11 , C07H21/00 , C40B50/14 , C40B60/14 , Y02P20/542
摘要: A method of fabricating polynucleotide arrays includes dissolving a nucleotide monomer, oligonucleotide, or polynucleotide in a solvent containing ionic liquid and depositing the resulting solution on an array substrate. The method has particular application to fabrication of an addressable array of polynucleotides on a substrate that carries substrate bound moieties each with a hydroxyl group. The process may be repeated at specific locations on the array to elongate the polynucleotide deposited on the array.
摘要翻译: 制备多核苷酸阵列的方法包括将核苷酸单体,寡核苷酸或多核苷酸溶解在含有离子液体的溶剂中,并将所得溶液沉积在阵列基底上。 该方法特别适用于在载体上具有羟基的底物结合部分的底物上制造多核苷酸可寻址阵列。 该过程可以在阵列上的特定位置重复以延长沉积在阵列上的多核苷酸。
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