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公开(公告)号：US08318951B2
公开(公告)日：2012-11-27
申请号：US13116574
申请日：2011-05-26
IPC分类号： C07D405/14 , C07D413/04 , A61K31/4155 , A61K31/422 , A61P29/00 , C12N5/0775 , C12N5/0797
CPC分类号： C07D413/04 , A61K31/415 , A61K31/4155 , A61K31/42 , A61K31/422 , A61K31/427 , A61K31/4439 , A61K31/496 , A61K31/5377 , C07C311/49 , C07D231/12 , C07D261/08 , C07D261/18 , C07D403/04 , C07D405/04 , C07D409/04 , C07D413/14 , C07D417/04 , C12N5/0618 , C12N5/0657 , C12N2501/999
摘要： The present invention relates to screens for compounds that can induce stem cell differentiation. In addition, isoxazoles and sulfonyl hydrazones are identified as general classes of compounds that can induce differentiation of stem cells into cells of neuronal and cardiac fate, respectively.
摘要翻译： 本发明涉及可诱导干细胞分化的化合物的筛选。 此外，异恶唑和磺酰腙被鉴定为可以分别诱导干细胞分化为神经元和心脏命运细胞的化合物的一般类别。
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公开(公告)号：US20120029200A1
公开(公告)日：2012-02-02
申请号：US13116574
申请日：2011-05-26
IPC分类号： C07D413/04
CPC分类号： C07D413/04 , A61K31/415 , A61K31/4155 , A61K31/42 , A61K31/422 , A61K31/427 , A61K31/4439 , A61K31/496 , A61K31/5377 , C07C311/49 , C07D231/12 , C07D261/08 , C07D261/18 , C07D403/04 , C07D405/04 , C07D409/04 , C07D413/14 , C07D417/04 , C12N5/0618 , C12N5/0657 , C12N2501/999
摘要： The present invention relates to screens for compounds that can induce stem cell differentiation. In addition, isoxazoles and sulfonyl hydrazones are identified as general classes of compounds that can induce differentiation of stem cells into cells of neuronal and cardiac fate, respectively.
摘要翻译： 本发明涉及可诱导干细胞分化的化合物的筛选。 此外，异恶唑和磺酰腙被鉴定为可以分别诱导干细胞分化为神经元和心脏命运细胞的化合物的一般类别。
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公开(公告)号：US08778940B2
公开(公告)日：2014-07-15
申请号：US13487963
申请日：2012-06-04
IPC分类号： A61K31/422 , A61K31/427 , A61K31/4439 , A61K31/496 , A61K31/5377 , A61K31/415 , A61K31/4155 , A61K31/42
CPC分类号： C07D413/04 , A61K31/415 , A61K31/4155 , A61K31/42 , A61K31/422 , A61K31/427 , A61K31/4439 , A61K31/496 , A61K31/5377 , C07C311/49 , C07D231/12 , C07D261/08 , C07D261/18 , C07D403/04 , C07D405/04 , C07D409/04 , C07D413/14 , C07D417/04 , C12N5/0618 , C12N5/0657 , C12N2501/999
摘要： The present invention relates to compounds and methods for inducing neuronal differentiation in normal neural stem cells and brain cancer stem cells. The methods may take place in vitro, such as in isolates from the adult mammalian brain, or in vivo. Compounds and methods described herein may find use in the treatment of neurodegenerative and psychiatric diseases, the repair and regeneration of the nervous system, and in treatment of neurologic malignancy.
摘要翻译： 本发明涉及在正常神经干细胞和脑癌干细胞中诱导神经元分化的化合物和方法。 该方法可以在体外进行，例如在来自成年哺乳动物脑的分离物中，或在体内。 本文所述的化合物和方法可用于治疗神经变性和精神疾病，神经系统的修复和再生以及治疗神经恶性肿瘤。
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4.发明授权Isoxazole amides, derivatives and methods of chemical induction of neurogenesis 有权异恶唑酰胺，衍生物和化学诱导神经发生的方法公开(公告)号：US08193225B2
公开(公告)日：2012-06-05
申请号：US11974479
申请日：2007-10-12
IPC分类号： A61K31/422 , C07D261/18
CPC分类号： C07D413/04 , A61K31/415 , A61K31/4155 , A61K31/42 , A61K31/422 , A61K31/427 , A61K31/4439 , A61K31/496 , A61K31/5377 , C07C311/49 , C07D231/12 , C07D261/08 , C07D261/18 , C07D403/04 , C07D405/04 , C07D409/04 , C07D413/14 , C07D417/04 , C12N5/0618 , C12N5/0657 , C12N2501/999
摘要： The present invention relates to compounds and methods for inducing neuronal differentiation in normal neural stem cells and brain cancer stem cells. The compounds are isoxazole amides and derivatives thereof. The methods may take place in vitro, such as in isolates from the adult mammalian brain, or in vivo. Compounds and methods described herein may find use in the treatment of neurodegenerative and psychiatric diseases, the repair and regeneration of the nervous system, and in treatment of neurologic malignancy.
摘要翻译： 本发明涉及在正常神经干细胞和脑癌干细胞中诱导神经元分化的化合物和方法。 化合物是异恶唑酰胺及其衍生物。 该方法可以在体外进行，例如在来自成年哺乳动物脑的分离物中，或在体内。 本文所述的化合物和方法可用于治疗神经变性和精神疾病，神经系统的修复和再生以及治疗神经恶性肿瘤。
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公开(公告)号：US20090076103A1
公开(公告)日：2009-03-19
申请号：US12183884
申请日：2008-07-31
申请人： Eric Olson , Douglas Frantz , Jenny Hsieh , Steven L. McKnight , Jay Schneider
发明人： Eric Olson , Douglas Frantz , Jenny Hsieh , Steven L. McKnight , Jay Schneider
IPC分类号： A61K31/18 , C12N5/06 , C12Q1/66 , C12Q1/68 , A01K67/027 , C07C311/15 , A61P35/00 , C07D413/04 , C07D405/06 , C07D409/06 , A61K31/422 , A61K31/4155
CPC分类号： C07D413/04 , A61K31/415 , A61K31/4155 , A61K31/42 , A61K31/422 , A61K31/427 , A61K31/4439 , A61K31/496 , A61K31/5377 , C07C311/49 , C07D231/12 , C07D261/08 , C07D261/18 , C07D403/04 , C07D405/04 , C07D409/04 , C07D413/14 , C07D417/04 , C12N5/0618 , C12N5/0657 , C12N2501/999
摘要： The present invention relates to screens for compounds that can induce stem cell differentiation. In addition, isoxazoles and sulfonyl hydrazones are identified as general classes of compounds that can induce differentiation of stem cells into cells of neuronal and cardiac fate, respectively.
摘要翻译： 本发明涉及可诱导干细胞分化的化合物的筛选。 此外，异恶唑和磺酰腙被鉴定为可以分别诱导干细胞分化为神经元和心脏命运细胞的化合物的一般类别。
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公开(公告)号：US20130143885A1
公开(公告)日：2013-06-06
申请号：US13487963
申请日：2012-06-04
IPC分类号： C07D413/04 , A61K31/5377 , C07D417/04 , C07D403/14 , A61K31/496 , C07D413/14
CPC分类号： C07D413/04 , A61K31/415 , A61K31/4155 , A61K31/42 , A61K31/422 , A61K31/427 , A61K31/4439 , A61K31/496 , A61K31/5377 , C07C311/49 , C07D231/12 , C07D261/08 , C07D261/18 , C07D403/04 , C07D405/04 , C07D409/04 , C07D413/14 , C07D417/04 , C12N5/0618 , C12N5/0657 , C12N2501/999
摘要： The present invention relates to compounds and methods for inducing neuronal differentiation in normal neural stem cells and brain cancer stem cells. The methods may take place in vitro, such as in isolates from the adult mammalian brain, or in vivo. Compounds and methods described herein may find use in the treatment of neurodegenerative and psychiatric diseases, the repair and regeneration of the nervous system, and in treatment of neurologic malignancy.
摘要翻译： 本发明涉及在正常神经干细胞和脑癌干细胞中诱导神经元分化的化合物和方法。 该方法可以在体外进行，例如在来自成年哺乳动物脑的分离物中，或在体内。 本文所述的化合物和方法可用于治疗神经变性和精神疾病，神经系统的修复和再生以及治疗神经恶性肿瘤。
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公开(公告)号：US07981935B2
公开(公告)日：2011-07-19
申请号：US12183884
申请日：2008-07-31
申请人： Eric Olson , Douglas Frantz , Jenny Hsieh , Steven L. McKnight , Jay Schneider
发明人： Eric Olson , Douglas Frantz , Jenny Hsieh , Steven L. McKnight , Jay Schneider
IPC分类号： A61K31/18 , C07C311/49 , C12N5/074
CPC分类号： C07D413/04 , A61K31/415 , A61K31/4155 , A61K31/42 , A61K31/422 , A61K31/427 , A61K31/4439 , A61K31/496 , A61K31/5377 , C07C311/49 , C07D231/12 , C07D261/08 , C07D261/18 , C07D403/04 , C07D405/04 , C07D409/04 , C07D413/14 , C07D417/04 , C12N5/0618 , C12N5/0657 , C12N2501/999
摘要： The present invention relates to screens for compounds that can induce stem cell differentiation. In addition, isoxazoles and sulfonyl hydrazones are identified as general classes of compounds that can induce differentiation of stem cells into cells of neuronal and cardiac fate, respectively.
摘要翻译： 本发明涉及可诱导干细胞分化的化合物的筛选。 此外，异恶唑和磺酰腙被鉴定为可以分别诱导干细胞分化为神经元和心脏命运细胞的化合物的一般类别。
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公开(公告)号：US20090036451A1
公开(公告)日：2009-02-05
申请号：US11974479
申请日：2007-10-12
IPC分类号： A61K31/422 , C07D261/18 , C07D249/10 , C07D271/06 , A61P35/00 , C12N1/38 , A61K31/5377
CPC分类号： C07D413/04 , A61K31/415 , A61K31/4155 , A61K31/42 , A61K31/422 , A61K31/427 , A61K31/4439 , A61K31/496 , A61K31/5377 , C07C311/49 , C07D231/12 , C07D261/08 , C07D261/18 , C07D403/04 , C07D405/04 , C07D409/04 , C07D413/14 , C07D417/04 , C12N5/0618 , C12N5/0657 , C12N2501/999
摘要： The present invention relates to compounds and methods for inducing neuronal differentiation in normal neural stem cells and brain cancer stem cells. The methods may take place in vitro, such as in isolates from the adult mammalian brain, or in vivo. Compounds and methods described herein may find use in the treatment of neurodegenerative and psychiatric diseases, the repair and regeneration of the nervous system, and in treatment of neurologic malignancy.
摘要翻译： 本发明涉及在正常神经干细胞和脑癌干细胞中诱导神经元分化的化合物和方法。 该方法可以在体外进行，例如在来自成年哺乳动物脑的分离物中，或在体内。 本文所述的化合物和方法可用于治疗神经变性和精神疾病，神经系统的修复和再生以及治疗神经恶性肿瘤。
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公开(公告)号：US20070129412A1
公开(公告)日：2007-06-07
申请号：US11565847
申请日：2006-12-01
申请人： Jay Schneider
发明人： Jay Schneider
IPC分类号： A61K31/42 , A61K31/198 , A61K31/137
CPC分类号： A61K31/198 , A61K31/495 , A61K2300/00
摘要： The efficacy of levodopa therapy in patients being treated for Parkinson's disease is enhanced by administering high doses of a partial glycine agonist. The frequency and severity of levodopa-induced side effects in Parkinson's disease patients are also reduced by administration of a partial glycine agonist.
摘要翻译： 通过施用高剂量的部分甘氨酸激动剂，提高了治疗帕金森病患者左旋多巴治疗的疗效。 通过施用部分甘氨酸激动剂，也减少了在帕金森病患者中左旋多巴诱导的副作用的频率和严重程度。
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公开(公告)号：US20070093503A1
公开(公告)日：2007-04-26
申请号：US11565831
申请日：2006-12-01
申请人： Jay Schneider
发明人： Jay Schneider
IPC分类号： A61K31/495 , A61K31/137
CPC分类号： A61K31/198 , A61K31/495 , A61K2300/00
摘要： The efficacy of levodopa therapy in patients being treated for Parkinson's disease is enhanced by administering high doses of a partial glycine agonist. The frequency and severity of levodopa-induced side effects in Parkinson's disease patients are also reduced by administration of a partial glycine agonist.
摘要翻译： 通过施用高剂量的部分甘氨酸激动剂，提高了治疗帕金森病患者左旋多巴治疗的疗效。 通过施用部分甘氨酸激动剂，也减少了在帕金森病患者中左旋多巴诱导的副作用的频率和严重程度。
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