利索-全球专利检索

  1. 登录
  2. 注册

搜索结果

39 条记录 (耗时 0.026 秒)

    Methods of manufacturing crystalline forms of rapamycin analogs
    3.
    发明授权
    Methods of manufacturing crystalline forms of rapamycin analogs 有权
    制备雷帕霉素类似物结晶形式的方法

    公开(公告)号：US08034926B2

    公开(公告)日：2011-10-11

    申请号：US12886398

    申请日：2010-09-20

    申请人： Shekhar Viswanath ,  Larry Bartelt ,  Robert Leanna ,  Michael Rasmussen ,  Madhup Dhaon ,  Rodger Henry ,  Thomas Borchardt ,  Shuang Chen ,  Geoff Zhang

    发明人： Shekhar Viswanath ,  Larry Bartelt ,  Robert Leanna ,  Michael Rasmussen ,  Madhup Dhaon ,  Rodger Henry ,  Thomas Borchardt ,  Shuang Chen ,  Geoff Zhang

    IPC分类号： C07D498/18

    CPC分类号： C07D498/18

    摘要： A process for preparing a crystalline rapamycin analog includes: combining the rapamycin analog with an organic medium to form a mixture; incubating the mixture until the rapamycin analog crystallizes; and recovering the crystalline rapamycin analog. The organic medium can be a solvent, and the process can include causing the rapamycin analog to dissolve into the solvent, and incubating the solvent until the rapamycin analog crystallizes. The following can also be performed: forming a slurry of crystalline rapamycin analog; stirring the rapamycin analog mixture until the rapamycin analog crystallizes; saturating the rapamycin analog solution; forming a supersaturated rapamycin analog solution; combining an antisolvent with the rapamycin analog and the solvent to form a biphasic mixture, and incubating the biphasic mixture to cause a liquid-liquid phase split.

    摘要翻译： 制备结晶雷帕霉素类似物的方法包括：将雷帕霉素类似物与有机介质结合以形成混合物; 孵育混合物直到雷帕霉素类似物结晶; 并回收结晶雷帕霉素类似物。 有机介质可以是溶剂，并且该方法可以包括使雷帕霉素类似物溶解到溶剂中，并将溶剂温育直到雷帕霉素类似物结晶。 还可以进行以下操作：形成结晶雷帕霉素类似物的浆液; 搅拌雷帕霉素类似物混合物直到雷帕霉素类似物结晶; 饱和雷帕霉素类似物溶液; 形成过饱和雷帕霉素类似物溶液; 将抗溶剂与雷帕霉素类似物和溶剂组合以形成双相混合物，并将两相混合物温育以引起液 - 液相分裂。

    Methods of manufacturing crystalline forms of rapamycin analogs
    6.
    发明授权
    Methods of manufacturing crystalline forms of rapamycin analogs 有权
    制备雷帕霉素类似物结晶形式的方法

    公开(公告)号：US07820812B2

    公开(公告)日：2010-10-26

    申请号：US11781807

    申请日：2007-07-23

    申请人： Shekhar Viswanath ,  Larry Bartelt ,  Robert Leanna ,  Michael Rasmussen ,  Madhup Dhaon ,  Rodger Henry ,  Thomas Borchardt ,  Shuang Chen ,  Geoff Zhang

    发明人： Shekhar Viswanath ,  Larry Bartelt ,  Robert Leanna ,  Michael Rasmussen ,  Madhup Dhaon ,  Rodger Henry ,  Thomas Borchardt ,  Shuang Chen ,  Geoff Zhang

    IPC分类号： C07D498/18

    CPC分类号： C07D498/18

    摘要： A process for preparing a crystalline rapamycin analog includes: combining the rapamycin analog with an organic medium to form a mixture; incubating the mixture until the rapamycin analog crystallizes; and recovering the crystalline rapamycin analog. The organic medium can be a solvent, and the process can include causing the rapamycin analog to dissolve into the solvent, and incubating the solvent until the rapamycin analog crystallizes. The following can also be performed: forming a slurry of crystalline rapamycin analog; stirring the rapamycin analog mixture until the rapamycin analog crystallizes; saturating the rapamycin analog solution; forming a supersaturated rapamycin analog solution; combining an antisolvent with the rapamycin analog and the solvent to form a biphasic mixture, and incubating the biphasic mixture to cause a liquid-liquid phase split.

    摘要翻译： 制备结晶雷帕霉素类似物的方法包括：将雷帕霉素类似物与有机介质结合以形成混合物; 孵育混合物直到雷帕霉素类似物结晶; 并回收结晶雷帕霉素类似物。 有机介质可以是溶剂，并且该方法可以包括使雷帕霉素类似物溶解到溶剂中，并将溶剂温育直到雷帕霉素类似物结晶。 还可以进行以下操作：形成结晶雷帕霉素类似物的浆液; 搅拌雷帕霉素类似物混合物直到雷帕霉素类似物结晶; 饱和雷帕霉素类似物溶液; 形成过饱和雷帕霉素类似物溶液; 将抗溶剂与雷帕霉素类似物和溶剂组合以形成双相混合物，并将两相混合物温育以引起液 - 液相分裂。

    Methods of Manufacturing Crystalline Forms of Rapamycin Analogs
    8.
    发明申请
    Methods of Manufacturing Crystalline Forms of Rapamycin Analogs 审中-公开
    雷帕霉素类似物的结晶形式的制备方法

    公开(公告)号：US20120028908A1

    公开(公告)日：2012-02-02

    申请号：US13251207

    申请日：2011-10-01

    申请人： Shekhar VISWANATH ,  Larry Bartelt ,  Robert Leanna ,  Michael Rasmussen ,  Madhup Dhaon ,  Rodger Henry ,  Thomas Borchardt ,  Shuang Chen ,  Geoff Zhang

    发明人： Shekhar VISWANATH ,  Larry Bartelt ,  Robert Leanna ,  Michael Rasmussen ,  Madhup Dhaon ,  Rodger Henry ,  Thomas Borchardt ,  Shuang Chen ,  Geoff Zhang

    IPC分类号： A61K38/16 ,  A61K31/437 ,  A61K31/7048 ,  A61P35/00 ,  A61K31/565 ,  A61K31/56 ,  C07D498/12 ,  A61K31/5365 ,  A61K31/573

    CPC分类号： C07D498/18

    摘要： A process for preparing a crystalline rapamycin analog includes: combining the rapamycin analog with an organic medium to form a mixture; incubating the mixture until the rapamycin analog crystallizes; and recovering the crystalline rapamycin analog. The organic medium can be a solvent, and the process can include causing the rapamycin analog to dissolve into the solvent, and incubating the solvent until the rapamycin analog crystallizes. The following can also be performed: forming a slurry of crystalline rapamycin analog; stirring the rapamycin analog mixture until the rapamycin analog crystallizes; saturating the rapamycin analog solution; forming a supersaturated rapamycin analog solution; combining an antisolvent with the rapamycin analog and the solvent to form a biphasic mixture, and incubating the biphasic mixture to cause a liquid-liquid phase split.

    摘要翻译： 制备结晶雷帕霉素类似物的方法包括：将雷帕霉素类似物与有机介质结合以形成混合物; 孵育混合物直到雷帕霉素类似物结晶; 并回收结晶雷帕霉素类似物。 有机介质可以是溶剂，并且该方法可以包括使雷帕霉素类似物溶解到溶剂中，并将溶剂温育直到雷帕霉素类似物结晶。 还可以进行以下操作：形成结晶雷帕霉素类似物的浆液; 搅拌雷帕霉素类似物混合物直到雷帕霉素类似物结晶; 饱和雷帕霉素类似物溶液; 形成过饱和雷帕霉素类似物溶液; 将抗溶剂与雷帕霉素类似物和溶剂组合以形成双相混合物，并将两相混合物温育以引起液 - 液相分裂。