公开(公告)号：US09211319B2

公开(公告)日：2015-12-15

申请号：US13143338

申请日：2010-01-08

申请人： Eric Sievers ,  Dana Kennedy ,  Nathan Ihle ,  Michael Sun

发明人： Eric Sievers ,  Dana Kennedy ,  Nathan Ihle ,  Michael Sun

IPC分类号： A61K39/395 ,  A61K39/00 ,  A61K47/48

CPC分类号： A61K47/48561 ,  A61K38/05 ,  A61K39/00 ,  A61K47/48384 ,  A61K47/48415 ,  A61K47/4863 ,  A61K47/48715 ,  A61K47/6803 ,  A61K47/6811 ,  A61K47/6849 ,  A61K47/6867 ,  A61K47/6889 ,  A61K2039/505 ,  C07K16/2878 ,  C07K16/3061 ,  C07K2317/56 ,  C07K2317/565 ,  C07K2317/77

摘要： Methods for the treatment of CD30-expressing cancers are provided. The methods comprise administering to a subject in need thereof a weekly dose of from about 0.8 mg/kg to about 1.8 mg/kg of an antibody-drug conjugate compound having formula (I); or a pharmaceutically acceptable salt thereof; wherein: mAb is an anti-CD30 antibody unit, S is a sulfur atom of the antibody, A- is a Stretcher unit, and p is from about 3 to about 5.

摘要翻译： 提供了治疗表达CD30的癌症的方法。 所述方法包括向有需要的受试者施用约0.8mg / kg至约1.8mg / kg的具有式（I）的抗体 - 药物偶联化合物的周剂量; 或其药学上可接受的盐; 其中：mAb是抗CD30抗体单元，S是抗体的硫原子，A-是担架单元，p是约3至约5。

公开(公告)号：US20110268751A1

公开(公告)日：2011-11-03

申请号：US13143338

申请日：2010-01-08

申请人： Eric Sievers ,  Dana Kennedy ,  Nathan Ihle ,  Michael Sun

发明人： Eric Sievers ,  Dana Kennedy ,  Nathan Ihle ,  Michael Sun

IPC分类号： A61K39/395 ,  A61P35/00 ,  C07K17/00

CPC分类号： A61K47/48561 ,  A61K38/05 ,  A61K39/00 ,  A61K47/48384 ,  A61K47/48415 ,  A61K47/4863 ,  A61K47/48715 ,  A61K47/6803 ,  A61K47/6811 ,  A61K47/6849 ,  A61K47/6867 ,  A61K47/6889 ,  A61K2039/505 ,  C07K16/2878 ,  C07K16/3061 ,  C07K2317/56 ,  C07K2317/565 ,  C07K2317/77

摘要： Methods for the treatment of CD30-expressing cancers are provided. The methods comprise administering to a subject in need thereof a weekly dose of from about 0.8 mg/kg to about 1.8 mg/kg of an antibody-drug conjugate compound having formula (I); or a pharmaceutically acceptable salt thereof; wherein: mAb is an anti-CD30 antibody unit, S is a sulfur atom of the antibody, A—is a Stretcher unit, and p is from about 3 to about 5.

摘要翻译： 提供了治疗表达CD30的癌症的方法。 所述方法包括向有需要的受试者施用约0.8mg / kg至约1.8mg / kg的具有式（I）的抗体 - 药物偶联化合物的周剂量; 或其药学上可接受的盐; 其中：mAb是抗CD30抗体单元，S是抗体的硫原子，A是担架单元，p是约3至约5。

公开(公告)号：USD963292S1

公开(公告)日：2022-09-13

申请号：US29726259

申请日：2020-03-02

申请人： Michael Sun

设计人： Michael Sun

公开(公告)号：US20090010945A1

公开(公告)日：2009-01-08

申请号：US10591743

申请日：2005-03-02

申请人： Stephen C. Alley ,  Michael Torgov ,  Michael Sun

发明人： Stephen C. Alley ,  Michael Torgov ,  Michael Sun

IPC分类号： A61K39/395 ,  C07K16/18 ,  C07K1/00 ,  A61P31/00 ,  A61K38/00 ,  C07K14/00

CPC分类号： C07K16/2878 ,  A61K47/6803 ,  A61K47/6849 ,  A61K2039/505 ,  Y02A50/412

摘要： A protein containing one or more activatable groups, e.g., an antibody, is subjected to partial or complete reduction of one or more such bonds to form reactive groups; the resulting protein is reacted with a drug which is reactive with some of the reactive groups, such as certain radiometals, chelating agents, and toxins, so as to form a conjugate useful in, e.g., in vitro diagnosis, in vivo imaging, and therapy.

摘要翻译： 含有一个或多个可激活基团（例如抗体）的蛋白质被部分或完全还原一个或多个这样的键以形成反应性基团; 所产生的蛋白质与与某些反应性基团如某些放射性金属螯合剂和毒素反应的药物反应，以便形成用于例如体外诊断，体内成像和治疗的缀合物 。

公开(公告)号：US20180197214A1

公开(公告)日：2018-07-12

申请号：US15401786

申请日：2017-01-09

申请人： Ghanshyam Rokde ,  Michael Sun ,  Swetha Devireddy ,  Shih-Kang Chang ,  Ankush Singhai

发明人： Ghanshyam Rokde ,  Michael Sun ,  Swetha Devireddy ,  Shih-Kang Chang ,  Ankush Singhai

IPC分类号： G06Q30/04 ,  G06F17/30 ,  G06Q20/10 ,  G06Q40/02 ,  G06Q30/02

CPC分类号： G06Q30/04 ,  G06F16/22 ,  G06F16/25 ,  G06Q20/02 ,  G06Q20/12 ,  G06Q20/385 ,  G06Q30/0226 ,  G06Q40/02

摘要： An electronic payment platform is modified to support merchant loyalty programs by implementing a database and user interfaces for both merchant and consumer participation. As transactions are processed, the electronic payment platform evaluates each transaction to determine if the consumer, and more particularly the payment instrument used in the transaction, is registered. If so, and the merchant is currently offering an award based on satisfying certain criteria, the current transaction data is added to previous qualifying transactions to determine if an award should be granted. If so, the electronic payment platform manages distribution of funds to a designated payment instrument of the consumer.

公开(公告)号：US07837980B2

公开(公告)日：2010-11-23

申请号：US10591743

申请日：2005-03-02

申请人： Stephen C. Alley ,  Michael Torgov ,  Michael Sun

发明人： Stephen C. Alley ,  Michael Torgov ,  Michael Sun

IPC分类号： A61K51/10 ,  A61K39/395 ,  C07K16/18 ,  C07K16/22 ,  C07K16/28 ,  C12P21/08

CPC分类号： C07K16/2878 ,  A61K47/6803 ,  A61K47/6849 ,  A61K2039/505 ,  Y02A50/412

摘要： A protein containing one or more activatable groups, e.g., an antibody, is subjected to partial or complete reduction of one or more such bonds to form reactive groups; the resulting protein is reacted with a drug which is reactive with some of the reactive groups, such as certain radiometals, chelating agents, and toxins, so as to form a conjugate useful in, e.g., in vitro diagnosis, in vivo imaging, and therapy.

摘要翻译： 含有一个或多个可激活基团（例如抗体）的蛋白质被部分或完全还原一个或多个这样的键以形成反应性基团; 所产生的蛋白质与与某些反应性基团如某些放射性金属螯合剂和毒素反应的药物反应，以便形成用于例如体外诊断，体内成像和治疗的缀合物 。

公开(公告)号：US06501651B2

公开(公告)日：2002-12-31

申请号：US09760944

申请日：2001-01-15

申请人： Bo-Yao Lin ,  Iris Huang ,  Michael Sun

发明人： Bo-Yao Lin ,  Iris Huang ,  Michael Sun

IPC分类号： H05K720

CPC分类号： H01L23/467 ,  H01L2924/0002 ,  H01L2924/00

摘要： A heat dissipation system for use with a computer chip includes a heat sink with a fan mounted aslant to the lateral side thereof. The heat sink includes a base having a first surface and a second surface. The computer chip is positioned in contact with the first surface. A heat dissipation unit is mounted on the second surface of the base. The heat dissipation unit includes a plurality of heat dissipation fins. An air-conducting device has a shape of an inverted U and is used to cover the heat dissipation unit. A fan is mounted aslant to a lateral side of the heat dissipation unit. The heat dissipation unit includes a plurality of rectangular dissipation fins. The fins are mutually parallel and are collocated above the base. The heat dissipation unit includes a predetermined number of heat dissipation fins having a common inclination to form an accommodating area on the lateral side of the heat dissipation unit. The fan is mounted aslant to the lateral side of the heat dissipation unit in the accommodating area.

公开(公告)号：US20110097322A1

公开(公告)日：2011-04-28

申请号：US12916294

申请日：2010-10-29

申请人： Stephen C. Alley ,  Michael Torgov ,  Michael Sun

发明人： Stephen C. Alley ,  Michael Torgov ,  Michael Sun

IPC分类号： A61K39/395 ,  A61P35/00 ,  A61P37/02 ,  A61P31/00

CPC分类号： C07K16/2878 ,  A61K47/6803 ,  A61K47/6849 ,  A61K2039/505 ,  Y02A50/412

摘要： A protein containing one or more activatable groups, e.g., an antibody, is subjected to partial or complete reduction of one or more such bonds to form reactive groups; the resulting protein is reacted with a drug which is reactive with some of the reactive groups, such as certain radiometals, chelating agents, and toxins, so as to form a conjugate useful in, e.g., in vitro diagnosis, in vivo imaging, and therapy.

摘要翻译： 含有一个或多个可激活基团（例如抗体）的蛋白质被部分或完全还原一个或多个这样的键以形成反应性基团; 所产生的蛋白质与与某些反应性基团如某些放射性金属螯合剂和毒素反应的药物反应，以便形成用于例如体外诊断，体内成像和治疗的缀合物 。

公开(公告)号：USD941554S1

公开(公告)日：2022-01-25

申请号：US29726253

申请日：2020-03-02

申请人： Michael Sun

设计人： Michael Sun

公开(公告)号：US07739660B2

公开(公告)日：2010-06-15

申请号：US11395407

申请日：2006-03-31

申请人： Michael Sun

发明人： Michael Sun

IPC分类号： G06F9/44 ,  G06F9/45

CPC分类号： G06F8/71

摘要： A system and method for managing codes during distributed software development. Code segments, or sections, are separated into logic units. Each logic unit contains one or more services. The logic units and services are registered at a registration management module, and added to the existing software code. When predefined automatic calling condition is satisfied, the corresponding service in every registered logic unit will be called automatically. Additionally, a unified interface is provided for calling services in the registered logic units. The calling of the logic unit may be affected by using the registration information of and/or a service definition defining the service of the logic unit maintained in the registration management module.

摘要翻译： 分布式软件开发期间管理代码的系统和方法。 代码段或部分分为逻辑单元。 每个逻辑单元包含一个或多个服务。 逻辑单元和服务在注册管理模块中注册，并添加到现有的软件代码中。 当满足预定义的自动呼叫条件时，将自动调用每个注册的逻辑单元中的相应服务。 另外，为注册的逻辑单元中的呼叫服务提供统一的接口。 逻辑单元的调用可能通过使用定义在注册管理模块中维护的逻辑单元的服务的注册信息和/或服务定义来影响。