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公开(公告)号：US07750116B1
公开(公告)日：2010-07-06
申请号：US11677029
申请日：2007-02-20
IPC分类号： C07K5/00
CPC分类号： C07K5/06052 , A61K47/6809 , A61K47/6811
摘要： Methods of treating a refractory or drug resistant cancer, cell proliferative disorder and tumor cells are provided. Also provided are antibody drug conjugate metabolites.
摘要翻译： 提供了治疗难治性或耐药性癌症，细胞增殖性病症和肿瘤细胞的方法。 还提供抗体药物偶联物代谢物。
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公开(公告)号：US07837980B2
公开(公告)日：2010-11-23
申请号：US10591743
申请日：2005-03-02
申请人： Stephen C. Alley , Michael Torgov , Michael Sun
发明人： Stephen C. Alley , Michael Torgov , Michael Sun
CPC分类号： C07K16/2878 , A61K47/6803 , A61K47/6849 , A61K2039/505 , Y02A50/412
摘要： A protein containing one or more activatable groups, e.g., an antibody, is subjected to partial or complete reduction of one or more such bonds to form reactive groups; the resulting protein is reacted with a drug which is reactive with some of the reactive groups, such as certain radiometals, chelating agents, and toxins, so as to form a conjugate useful in, e.g., in vitro diagnosis, in vivo imaging, and therapy.
摘要翻译： 含有一个或多个可激活基团（例如抗体）的蛋白质被部分或完全还原一个或多个这样的键以形成反应性基团; 所产生的蛋白质与与某些反应性基团如某些放射性金属螯合剂和毒素反应的药物反应，以便形成用于例如体外诊断，体内成像和治疗的缀合物 。
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3.发明授权Methods and compositions for making antibodies and antibody derivatives with reduced core fucosylation 有权用于制备具有降低核心岩藻糖基化的抗体和抗体衍生物的方法和组合物公开(公告)号：US08163551B2
公开(公告)日：2012-04-24
申请号：US12434533
申请日：2009-05-01
申请人： Stephen C. Alley , Scott C. Jeffrey , Django Sussman , Dennis R. Benjamin , Brian Toki , Patrick J. Burke
发明人： Stephen C. Alley , Scott C. Jeffrey , Django Sussman , Dennis R. Benjamin , Brian Toki , Patrick J. Burke
CPC分类号： C12N5/0037 , C07H13/04 , C07K16/00 , C07K2317/72 , C07K2317/732
摘要： The invention provides methods and compositions for preparing antibodies and antibody derivatives with reduced core fucosylation.
摘要翻译： 本发明提供了制备具有降低核心岩藻糖基化的抗体和抗体衍生物的方法和组合物。
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4.发明申请METHODS AND COMPOSITIONS FOR MAKING ANTIBODIES AND ANTIBODY DERIVATIVES WITH REDUCED CORE FUCOSYLATION 有权制备具有降低核心纤维蛋白原的抗体和抗体衍生物的方法和组合物公开(公告)号：US20090317869A1
公开(公告)日：2009-12-24
申请号：US12434533
申请日：2009-05-01
申请人： Stephen C. Alley , Scott C. Jeffrey , Django Sussman , Dennis R. Benjamin , Brian Toki , Patrick J. Burke
发明人： Stephen C. Alley , Scott C. Jeffrey , Django Sussman , Dennis R. Benjamin , Brian Toki , Patrick J. Burke
CPC分类号： C12N5/0037 , C07H13/04 , C07K16/00 , C07K2317/72 , C07K2317/732
摘要： The invention provides methods and compositions for preparing antibodies and antibody derivatives with reduced core fucosylation.
摘要翻译： 本发明提供了制备具有降低核心岩藻糖基化的抗体和抗体衍生物的方法和组合物。
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公开(公告)号：US20090010945A1
公开(公告)日：2009-01-08
申请号：US10591743
申请日：2005-03-02
申请人： Stephen C. Alley , Michael Torgov , Michael Sun
发明人： Stephen C. Alley , Michael Torgov , Michael Sun
CPC分类号： C07K16/2878 , A61K47/6803 , A61K47/6849 , A61K2039/505 , Y02A50/412
摘要： A protein containing one or more activatable groups, e.g., an antibody, is subjected to partial or complete reduction of one or more such bonds to form reactive groups; the resulting protein is reacted with a drug which is reactive with some of the reactive groups, such as certain radiometals, chelating agents, and toxins, so as to form a conjugate useful in, e.g., in vitro diagnosis, in vivo imaging, and therapy.
摘要翻译： 含有一个或多个可激活基团（例如抗体）的蛋白质被部分或完全还原一个或多个这样的键以形成反应性基团; 所产生的蛋白质与与某些反应性基团如某些放射性金属螯合剂和毒素反应的药物反应，以便形成用于例如体外诊断，体内成像和治疗的缀合物 。
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公开(公告)号：US08574907B2
公开(公告)日：2013-11-05
申请号：US13405143
申请日：2012-02-24
申请人： Stephen C. Alley , Scott C. Jeffrey , Django Sussman , Dennis R. Benjamin , Brian Toki , Patrick J. Burke
发明人： Stephen C. Alley , Scott C. Jeffrey , Django Sussman , Dennis R. Benjamin , Brian Toki , Patrick J. Burke
IPC分类号： C12N5/00
CPC分类号： C12N5/0037 , C07H13/04 , C07K16/00 , C07K2317/72 , C07K2317/732
摘要： The invention provides methods and compositions for preparing antibodies and antibody derivatives with reduced core fucosylation.
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7.发明申请METHODS AND COMPOSITIONS FOR MAKING ANTIBODIES AND ANTIBODY DERIVATIVES WITH REDUCED CORE FUCOSYLATION 有权制备具有降低核心纤维蛋白原的抗体和抗体衍生物的方法和组合物公开(公告)号：US20120183997A1
公开(公告)日：2012-07-19
申请号：US13405143
申请日：2012-02-24
申请人： STEPHEN C. ALLEY , Scott C. Jeffrey , Django Sussman , Dennis R. Benjamin , Brian Toki , Patrick J. Burke
发明人： STEPHEN C. ALLEY , Scott C. Jeffrey , Django Sussman , Dennis R. Benjamin , Brian Toki , Patrick J. Burke
CPC分类号： C12N5/0037 , C07H13/04 , C07K16/00 , C07K2317/72 , C07K2317/732
摘要： The invention provides methods and compositions for preparing antibodies and antibody derivatives with reduced core fucosylation.
摘要翻译： 本发明提供了制备具有降低核心岩藻糖基化的抗体和抗体衍生物的方法和组合物。
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公开(公告)号：US20110097322A1
公开(公告)日：2011-04-28
申请号：US12916294
申请日：2010-10-29
申请人： Stephen C. Alley , Michael Torgov , Michael Sun
发明人： Stephen C. Alley , Michael Torgov , Michael Sun
IPC分类号： A61K39/395 , A61P35/00 , A61P37/02 , A61P31/00
CPC分类号： C07K16/2878 , A61K47/6803 , A61K47/6849 , A61K2039/505 , Y02A50/412
摘要： A protein containing one or more activatable groups, e.g., an antibody, is subjected to partial or complete reduction of one or more such bonds to form reactive groups; the resulting protein is reacted with a drug which is reactive with some of the reactive groups, such as certain radiometals, chelating agents, and toxins, so as to form a conjugate useful in, e.g., in vitro diagnosis, in vivo imaging, and therapy.
摘要翻译： 含有一个或多个可激活基团（例如抗体）的蛋白质被部分或完全还原一个或多个这样的键以形成反应性基团; 所产生的蛋白质与与某些反应性基团如某些放射性金属螯合剂和毒素反应的药物反应，以便形成用于例如体外诊断，体内成像和治疗的缀合物 。
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