公开(公告)号：US4016262A

公开(公告)日：1977-04-05

申请号：US582529

申请日：1975-05-30

申请人： Erich Fauland ,  Wolfgang Kampe ,  Kurt Stach, deceased ,  by Werner Plattner, executor ,  Harald Stork ,  Karl Dietmann

发明人： Erich Fauland ,  Wolfgang Kampe ,  Kurt Stach, deceased ,  by Werner Plattner, executor ,  Harald Stork ,  Karl Dietmann

IPC分类号： C07H19/16 ,  A61K31/70

CPC分类号： C07H19/16

摘要： N(6)-disubstituted adenosine compounds of the formula: ##STR1## wherein R.sub.1 is alkenyl, cycloalkenyl or cycloalkenyl-alkyl; andR.sub.2 is alkenyl, cycloalkenyl, straight or branched-chain alkyl, cycloalkyl, bicycloalkyl, alkyl-cycloalkyl, or alkyl-bicycloalkyl;And the pharmacologically compatible salts thereof; exhibit outstanding anti-lipolytic, anti-hyperlipaemic and anti-hypercholesterolaemic action.

摘要翻译： 具有下式的N（6） - 二取代的腺苷化合物：其中R 1是烯基，环烯基或环烯基 - 烷基; R 2为烯基，环烯基，直链或支链烷基，环烷基，二环烷基，烷基 - 环烷基或烷基 - 双环烷基; 及其药理学兼容性; 展示超耐药，抗高血压和抗高胆固醇血管作用。

公开(公告)号：US3966916A

公开(公告)日：1976-06-29

申请号：US525795

申请日：1974-11-21

申请人： Wolfgang Kampe ,  Erich Fauland ,  Kurt Stach ,  Harald Stork ,  Felix Helmut Schmidt

发明人： Wolfgang Kampe ,  Erich Fauland ,  Kurt Stach ,  Harald Stork ,  Felix Helmut Schmidt

IPC分类号： C07H19/16 ,  A61K31/70

CPC分类号： C07H19/16

摘要： New N(6)-disubstituted adenosine compound of the formula ##SPC1##WhereinR.sub.1 is lower alkyl substituted by at least one of hydroxyl, alkoxy or acyloxy; or is cycloalkyl or straight-chained or branched lower alkenyl;R.sub.2 and R.sub.3 are hydrogen, halogen, or nitro or lower alkyl, alkoxy or alkylthio andR.sub.4 is hydrogen or acyl; when R.sub.4 is acyl, R.sub.1 can also be lower alkyl;And the pharmacologicaly compatible salts thereof; exhibits shown anti-lipolytic, anti-hyperlipaemic and anti-hypercholesterolaemic action.

摘要翻译： 新的N（6） - 二取代的腺苷化合物，式WHERE R1是被羟基，烷氧基或酰氧基中的至少一个取代的低级烷基; 或是环烷基或直链或支链低级链烯基; R2和R3是氢，卤素或硝基或低级烷基，烷氧基或烷硫基，R4是氢或酰基; 当R 4是酰基时，R 1也可以是低级烷基; 及其药理学兼容性; 展示了抗脂肪，抗高血压和抗高血脂药物作用。

公开(公告)号：US3988317A

公开(公告)日：1976-10-26

申请号：US303290

申请日：1972-11-02

申请人： Wolfgang Kampe ,  Klaus Koch ,  Kurt Stach ,  Harald Stork ,  Felix Helmut Schmidt

发明人： Wolfgang Kampe ,  Klaus Koch ,  Kurt Stach ,  Harald Stork ,  Felix Helmut Schmidt

IPC分类号： C07H19/167 ,  C07D473/00 ,  C07H19/16

CPC分类号： C07H19/16

摘要： New heterocyclic-substituted nebularin compounds of the formula: ##SPC1##WhereinR.sub.1 is hydrogen, halogen or amino;R.sub.2 and R.sub.3, which may be the same or different, are hydrogen, hydroxyl, lower alkyl, alkoxy or hydroxyalkyl; andn is 2 or 3 or, when R.sub.1 is a halogen atom or an amino group, n can also be 1; and the pharmacologically compatible salts thereof;Are outstandingly effective in reducing body fat levels in mammals, e.g., the concentration of free fatty acids, of triglycerides and of cholesterol in serum.

摘要翻译： 新的具有下式的杂环取代的新型白蛋白化合物：

公开(公告)号：US4153728A

公开(公告)日：1979-05-08

申请号：US733542

申请日：1976-10-18

申请人： Hans P. Wolff ,  Ernst-Christian Witte ,  Max Thiel ,  Harald Stork ,  Egon Roesch

发明人： Hans P. Wolff ,  Ernst-Christian Witte ,  Max Thiel ,  Harald Stork ,  Egon Roesch

IPC分类号： A61K31/215 ,  A61K20060101 ,  A61K31/16 ,  A61K31/19 ,  A61K31/22 ,  A61P3/06 ,  A61P7/02 ,  C07C20060101 ,  C07C51/00 ,  C07C59/68 ,  C07C67/00 ,  C07C69/734 ,  C07C69/76 ,  C07C231/00 ,  C07C231/02 ,  C07C231/12 ,  C07C235/34 ,  C07C235/48 ,  C07C101/42 ,  A01N9/20

CPC分类号： C07C2101/14 ,  Y10S514/824

摘要： Novel phenoxyalkylcarboxylic acid compounds of the formula ##STR1## wherein B is a valency bond or a straight-chained or branched, saturated or unsaturated hydrocarbon radical containing up to 3 carbon atoms;N is 1 or 2 andR.sub.1, r.sub.2 and R.sub.3 are hydrogen or lower alkyl; and the pharmacologically compatible salts thereof; have been found to be outstandingly effective in lowering the serum lipid level and the cholesterol level in mammals without inducing undesired side effects and to possess excellent thrombocyte-aggregation inhibiting activity.

摘要翻译： 式（I）的新型苯氧基烷基羧酸化合物，其中B是含有至多3个碳原子的价键或直链或支链，饱和或不饱和的烃基; N 1 OR 2，R 1，R 2和R 3为氢或低级烷基; 和其药理学上相容的盐; 已被发现在降低哺乳动物血清脂质水平和胆固醇水平而没有诱导不期望的副作用并且具有优异的血小板聚集抑制活性方面是非常有效的。