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    Tricyclic aminoalkyl derivatives
    5.
    发明授权
    Tricyclic aminoalkyl derivatives 失效
    三环氨基烷基衍生物

    公开(公告)号：US4070373A

    公开(公告)日：1978-01-24

    申请号：US291426

    申请日：1972-09-22

    申请人： Werner Winter ,  Max Thiel ,  Kurt Stach, deceased ,  by Werner Plattner, administrator ,  Wolfgang Schaumann ,  Karl Dietmann

    发明人： Werner Winter ,  Max Thiel ,  Kurt Stach, deceased ,  by Werner Plattner, administrator ,  Wolfgang Schaumann ,  Karl Dietmann

    IPC分类号： C07D311/90 ,  C07D313/12 ,  C07D337/12 ,  C07D337/16

    CPC分类号： C07D337/16 ,  C07D311/90 ,  C07D313/12 ,  C07D337/12 ,  C07C2103/18

    摘要： Novel tricyclic aminoalkyl derivatives are disclosed which are characterized by valuable pharmacological activities and namely by cardiac and circulatory activities. The tricyclic aminoalkyl derivatives are compounds of the formula: ##STR1## wherein X is an oxygen or a sulfur atom, a saturated or unsaturated, straight chain or branched alkylene group containing up to 3 carbon atoms, an oxymethylene, thiamethylene or thiaethylene group or a valency bond, R.sub.1 is hydrogen, halogen, alkyl, alkoxy or trifluoromethyl, R.sub.2 is hydrogen or hydroxyl, R.sub.3 is hydrogen or together with R.sub.2 represents a further valency bond, R.sub.4 and R.sub.5 which may be the same or different are each hydrogen or lower alkyl, A is alkylene which is substituted by an optionally acylated hydroxyl group, Y is an oxygen or sulfur atom or an optionally alkylated imino group and Z is aryl, aralkyl, cycloalkyl or cycloalkyl-alkyl which may be substituted by halogen, hydroxyl, nitro, amino, alkoxy, aralkoxy, alkyl, trifluoromethyl, alkylamino or alkylsulfonyl group, and the acid addition salts thereof with pharmacologically acceptable acids.

    摘要翻译： 公开了新颖的三环氨基烷基衍生物，其特征在于有价值的药理活性，即通过心脏和循环活性。 三环氨基烷基衍生物是下式的化合物：其中X是氧或硫原子，含有至多3个碳原子的饱和或不饱和的直链或支链亚烷基，亚甲基，亚亚甲基或亚硫代亚乙基或 化合键，R 1是氢，卤素，烷基，烷氧基或三氟甲基，R 2是氢或羟基，R 3是氢或与R 2一起代表另外的价键，可以相同或不同的R 4和R 5各自是氢或低级烷基 A是被任意酰化的羟基取代的亚烷基，Y是氧或硫原子或任选烷基化的亚氨基，Z是可以被卤素，羟基，硝基取代的芳基，芳烷基，环烷基或环烷基 - 烷基， 氨基，烷氧基，芳烷氧基，烷基，三氟甲基，烷基氨基或烷基磺酰基，及其与药理学上可接受的酸的酸加成盐。

    Hypoglycaemically and hypolipidaemically active derivatives of phenyl-alkane-carboxylic acids
    6.
    发明授权
    Hypoglycaemically and hypolipidaemically active derivatives of phenyl-alkane-carboxylic acids 失效
    苯基 - 烷烃 - 羧酸的低血糖和降血糖活性衍生物

    公开(公告)号：US4238506A

    公开(公告)日：1980-12-09

    申请号：US920508

    申请日：1978-06-29

    申请人： Kurt Stach, deceased ,  Elmar Bosies ,  Ruth Heerdt ,  Hans-Frieder Kuhnle ,  Felix H. Schmidt

    发明人： Kurt Stach, deceased ,  Elmar Bosies ,  Ruth Heerdt ,  Hans-Frieder Kuhnle ,  Felix H. Schmidt

    IPC分类号： C07D213/82 ,  C07D241/24 ,  C07D307/79 ,  C07D311/66 ,  C07D333/38 ,  C07C101/42

    CPC分类号： C07D213/82 ,  C07D241/24 ,  C07D307/79 ,  C07D311/66 ,  C07D333/38 ,  C07C2103/18

    摘要： Phenyl-alkane-carboxylic acids of the formula ##STR1## wherein A is an aryl, aralkyl or arylvinyl radical optionally substituted by hydroxy, halogen, trifluoromethyl, alkyl, alkylthio, alkoxy, alkenyloxy, alkoxyalkoxy, alkyl-substituted amino, aryloxy or alkoxy-substituted aryloxy, or is an aryloxyalkyl or arylthioalkyl radical, or a heterocyclic ring system optionally substituted by halogen, alkyl or alkoxy,Y is a valency bond or an unbranched or branched lower alkylene radical containing up to 3 carbon atoms,X is a straight or branched, saturated or unsaturated divalent aliphatic hydrocarbon radical containing 2 to 8 carbon atoms, there being at least 2 carbon atoms between the benzene ring and the carboxyl group, andR is a hydrogen atom or a lower alkyl radical, as well as physiologically compatible salts, esters and amides thereof, exhibit hypoglycaemic and hypolipidaemic activity.

    摘要翻译： 式（I）的苯基 - 烷烃 - 羧酸其中A是任选被羟基，卤素，三氟甲基，烷基，烷硫基，烷氧基，烯氧基，烷氧基烷氧基，烷基取代的氨基，芳氧基 或烷氧基取代的芳氧基，或是芳氧基烷基或芳硫基烷基，或任选被卤素，烷基或烷氧基取代的杂环体系，Y是价态键或含有至多3个碳原子的无支链或支链低级亚烷基，X是 含有2至8个碳原子的直链或支链，饱和或不饱和的二价脂族烃基，苯环和羧基之间至少有2个碳原子，R是氢原子或低级烷基，以及 其生理上相容的盐，酯和酰胺显示出低血糖和降血脂活性。