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公开(公告)号：US20090215729A1
公开(公告)日：2009-08-27
申请号：US12389325
申请日：2009-02-19
申请人： Erin M. Johnson , Mark E. Johnson
发明人： Erin M. Johnson , Mark E. Johnson
IPC分类号： A61K31/663 , A61P35/00
CPC分类号： A61K9/143 , A61K9/5115
摘要： This invention provides pharmaceutical compositions and methods related to the prevention and treatment of primary tumors and metastatic, malignant or spreading cancers by selectively targeting cancer associated myeloid derived cells by the targeted delivery of a bisphosphonate formulated with a non-liposomal particle carrier. In some aspects, the bisphosphonate particles have one or more properties suitable for phagocytosis by cancer associated myeloid derived cells and release of the bisphosphonate within the macrophages. Advantageously, administering the particles to a subject reduces the level and/or activity of cancer associated myeloid derived cells in the subject.
摘要翻译： 本发明提供了通过靶向递送用非脂质体颗粒载体配制的双膦酸盐选择性地靶向癌相关骨髓来源的细胞来预防和治疗原发性肿瘤和转移性，恶性或扩散性癌症的药物组合物和方法。 在一些方面，双膦酸盐颗粒具有一种或多种适用于癌相关骨髓衍生细胞的吞噬作用和在巨噬细胞内双膦酸盐释放的性质。 有利地，向受试者施用颗粒降低了受试者中癌相关骨髓衍生细胞的水平和/或活性。
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公开(公告)号：US09981799B2
公开(公告)日：2018-05-29
申请号：US13206455
申请日：2011-08-09
IPC分类号： B65D83/20
CPC分类号： B65D83/205 , B65D83/206
摘要： A method of dispensing includes the steps of exerting a force on an actuator of a dispenser having a conduit with an inlet and an outlet in a first non-actuation state, to place the actuator in a second actuation state. When the actuator is in the second actuation state, the inlet and the outlet of the actuator are moved from a first position to a second position.
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公开(公告)号：USD667574S1
公开(公告)日：2012-09-18
申请号：US29358056
申请日：2010-03-22
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公开(公告)号：US07458698B2
公开(公告)日：2008-12-02
申请号：US11424481
申请日：2006-06-15
申请人： Sarah E. Heathcock , Scott W. Demarest , Matthew Abbondanzio , Simon M. Conway , Kamran Faterioun , Ronald R. Dir , Edwin T. Horton , Kevin Harrity , David R. Carlson , Mark E. Johnson
发明人： Sarah E. Heathcock , Scott W. Demarest , Matthew Abbondanzio , Simon M. Conway , Kamran Faterioun , Ronald R. Dir , Edwin T. Horton , Kevin Harrity , David R. Carlson , Mark E. Johnson
IPC分类号： F21V33/00
CPC分类号： F21S9/02 , B44C5/005 , F21S6/001 , F21S10/005 , F21S10/02 , F21V23/0442 , F21V33/0004 , F21W2121/00 , F21Y2115/10 , G02B6/002 , G02B6/0068 , G02B6/0081 , H02J7/0044 , H02J7/025 , H02J50/10 , H02J50/40 , H05B33/0857 , H05B37/00
摘要： A portable light device is capable of generating light that is substantially uniformly distributed at its surface. The light device includes a housing having at least a translucent portion formed of a translucent material A first light source is disposed within the housing and is adapted to generate light. A first optical structure is positioned to direct at least a portion of the light from the first light source toward the housing translucent portion, and a second optical structure is positioned between the first light source and the housing translucent portion, the second optical structure being adapted to diffuse at least a portion of the light for uniform distribution across the housing translucent portion.
摘要翻译： 便携式光装置能够产生在其表面上基本上均匀分布的光。 所述灯装置包括具有由透光材料形成的至少半透明部分的壳体。 第一光源设置在壳体内并且适于产生光。 第一光学结构被定位成将来自第一光源的光的至少一部分引导到壳体透光部分，并且第二光学结构位于第一光源和壳体半透明部分之间，第二光学结构适于 以扩散至少一部分光以均匀分布穿过壳体半透明部分。
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5.发明授权公开(公告)号：US06485897B1
公开(公告)日：2002-11-26
申请号：US09862923
申请日：2001-05-22
IPC分类号： G03C700
CPC分类号： G03C1/18 , G03C7/3041 , G03C2005/045
摘要： This invention relates to a photographic element comprising a support having thereon light sensitive silver halide layers comprising at least one red light sensitive silver halide layer, at least one green light sensitive silver halide layer, and at least one blue sensitive silver halide layer, wherein the green light sensitive silver halide layer has an absorption spectra having a maximum absorption at a wavelength &lgr;max from 530 to 560 nm and a half bandwidth less than 50 nm; and the red light sensitive silver halide layer has an adsorption spectra having a maximum absorption at a wavelength &lgr;max from 610 to 640 nm, and exhibiting from 30 nm hypsochromic of the wavelength of maximum absorption and below an area less than 40% based on the total area of the red light sensitive silver halide layer adsorption spectra. It further relates to a method of processing said element using an electronic filmwriter device.
摘要翻译： 本发明涉及一种照相元件，其中包括一个载体，其上具有包含至少一个红光感光卤化银层，至少一个绿色感光卤化银层和至少一个蓝色感光卤化银层的光敏卤化银层，其中 绿色感光卤化银层具有在530至560nm的波长范围内具有最大吸收的吸收光谱和小于50nm的半带宽; 并且红色感光卤化银层具有在610至640nm的波长lambdmax处具有最大吸收的吸收光谱，并且基于总计显示出最大吸收波长为30nm的低色度和小于40％的面积 区域的红光敏感卤化银层吸收光谱。 本发明还涉及一种使用电子作家装置处理所述元件的方法。
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6.发明申请公开(公告)号：US20140110495A1
公开(公告)日：2014-04-24
申请号：US13657686
申请日：2012-10-22
IPC分类号： A61L9/12
CPC分类号： A61L9/127 , A61L9/12 , A61L2209/11 , A61L2209/131 , A61L2209/133
摘要： A volatile material dispensing system includes a housing having at least one opening in a sidewall thereof and at least one engagement member extending from the housing. The volatile material dispensing system further includes a base adapted to interact with the housing, wherein the base includes a mechanical assembly. A reservoir contains a volatile material, wherein the reservoir rotates from a first position to a second position when the at least one engagement member contacts the mechanical assembly.
摘要翻译： 挥发性物质分配系统包括在其侧壁中具有至少一个开口的壳体和从壳体延伸的至少一个接合构件。 挥发性物质分配系统还包括适于与壳体相互作用的底座，其中底座包括机械组件。 储存器包含挥发性材料，其中当所述至少一个接合构件接触所述机械组件时，所述储存器从第一位置旋转到第二位置。
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公开(公告)号：US20130037582A1
公开(公告)日：2013-02-14
申请号：US13206455
申请日：2011-08-09
IPC分类号： B65D83/20
CPC分类号： B65D83/205 , B65D83/206
摘要： A method of dispensing includes the steps of exerting a force on an actuator of a dispenser having a conduit with an inlet and an outlet in a first non-actuation state, to place the actuator in a second actuation state. When the actuator is in the second actuation state, the inlet and the outlet of the actuator are moved from a first position to a second position.
摘要翻译： 一种分配方法包括以下步骤：在分配器的致动器上施加力，其具有导管，该导管具有处于第一非致动状态的入口和出口，以将致动器置于第二致动状态。 当致动器处于第二致动状态时，致动器的入口和出口从第一位置移动到第二位置。
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公开(公告)号：US08079478B2
公开(公告)日：2011-12-20
申请号：US12498931
申请日：2009-07-07
申请人： Michael E. Short , David A. Hoadley , Scott W. Demarest , Kit R. Morris , Sunny Kim , David R. Carlson , Mark E. Johnson
发明人： Michael E. Short , David A. Hoadley , Scott W. Demarest , Kit R. Morris , Sunny Kim , David R. Carlson , Mark E. Johnson
IPC分类号： B65D23/12
CPC分类号： A45D40/0087 , A47F7/286 , Y10S206/823
摘要： A fragrance sampling display for retail environments is disclosed. The sampling display may include a dock having a removable faceplate and sidewalls. The dock may include one or more receptacles and one or more scent modules, wherein each scent module is associated with and partially inserted into only one of the receptacles. The scent modules may be removably disposed in the corresponding receptacles by retractable cords. Each of the scent modules may include a different volatile active corresponding to a different fragrance product and vent holes to facilitate passive emission of the associated fragrance. The vent holes may be configured so as to be substantially sealed while the associated scent module is in its respective receptacle.
摘要翻译： 公开了用于零售环境的香味取样显示器。 采样显示器可以包括具有可拆卸面板和侧壁的坞站。 码头可以包括一个或多个插座和一个或多个香味模块，其中每个气味模块与仅一个插座相关联并且部分地插入其中一个插座。 气味模块可以通过可伸缩的绳索可拆卸地设置在相应的容器中。 每个气味模块可以包括对应于不同香料产品的不同挥发性活性物质和通气孔，以促进相关香料的被动排放。 通气孔可以构造成在相关联的气味模块在其相应的容器中时基本上被密封。
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公开(公告)号：US4882179A
公开(公告)日：1989-11-21
申请号：US245335
申请日：1988-09-15
申请人： James D. Beyer , Mark E. Johnson
发明人： James D. Beyer , Mark E. Johnson
IPC分类号： A23C19/032 , A23C19/05 , A23C19/06 , A23C19/14
CPC分类号： A23C19/14 , A23C19/0323 , A23C19/05 , A23C19/06
摘要： A method of manufacturing a specialty cheese according to the teachings of the present invention is disclosed relating to the manufacture of a creamy Havarti style cheese. According to the present invention, to reduce the moisture content, the curd is cooked at a temperature exceeding the recommended maximum temperature for optimum acid production for a mesophile culture and specifically at a temperature in the range of 104.degree. to 106.degree. F. for a cooking time in the range of one hour for retarding the culture growth to restrict the number of cells to reduce the bitterness in the cheese and for modifying the enzymatic activity of the starter organisms while still achieving acceptable acid production. Further, according to the present invention, the change of balance between the enzymatic activities previously accomplished by chilling the curd with a water bath treatment is accomplished by curing the cheese in a first curing regimen at a temperature in the range of 55.degree. to 65.degree. F. for in the range of 1 to 3 weeks to modify the enzymatic activities to favor the leuconostoc organisms responsible for flavor development and then by curing the cheese in a second curing regimen at a temperature in the range of 40.degree. to 45.degree. F. Elimination of the water bath treatment saves water, water disposal and time, and reduces the risk of product contamination.
摘要翻译： 公开了根据本发明的教导制造特种奶酪的方法，其涉及奶油型Havarti型奶酪的制造。 根据本发明，为了降低含水量，将凝乳在超过推荐最高温度的温度下烹饪，以达到嗜酸菌培养物的最佳酸产生，特别是在104至106°F的温度范围内。 在一小时范围内的烹饪时间用于延缓培养物生长以限制细胞数量以减少奶酪中的苦味并改变起始生物体的酶活性，同时仍然可以获得可接受的酸生产。 此外，根据本发明，先前通过冷冻凝乳与水浴处理而实现的酶活性之间的平衡变化通过在55度至65度的温度下在第一固化方案中固化所述干酪来实现 F.在1至3周的范围内修饰酶活性以有利于负责风味发展的亮氨酸生物，然后通过在40℃至45℃的温度下在第二固化方案中固化所述干酪。 消除水浴处理节省了水，水的处理和时间，降低了产品污染的风险。
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公开(公告)号：US4512690A
公开(公告)日：1985-04-23
申请号：US550796
申请日：1983-11-14
申请人： Mark E. Johnson
发明人： Mark E. Johnson
IPC分类号： A63H27/00
CPC分类号： A63H27/00
摘要： A toy glider includes a body portion of a low density lightweight construction such as foam having the appearance of a super hero with an opaque cape wing structure and a transparent extended portions of the wing structure attached to the back of the outstretched figure to provide a glider structure giving the appearance of a flying super hero.
摘要翻译： 玩具滑翔机包括低密度轻质结构的身体部分，例如具有不透明披肩翼结构的超级英雄的外观的泡沫，并且机翼结构的透明延伸部分附接到伸出的图形的背面以提供滑翔机 结构赋予飞行超级英雄的外观。
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