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    Modular knee prosthesis
    1.
    发明授权
    Modular knee prosthesis 有权
    模块膝关节假体

    公开(公告)号：US07297164B2

    公开(公告)日：2007-11-20

    申请号：US11205909

    申请日：2005-08-16

    申请人： Erin M. Johnson ,  Joseph Saladino

    发明人： Erin M. Johnson ,  Joseph Saladino

    IPC分类号： A61F2/38

    CPC分类号： A61F2/3859 ,  A61F2/38 ,  A61F2/389 ,  A61F2002/30187 ,  A61F2002/30331 ,  A61F2002/30332 ,  A61F2002/3038 ,  A61F2002/30382 ,  A61F2002/30604 ,  A61F2002/30616 ,  A61F2002/30878 ,  A61F2002/30892 ,  A61F2002/30975 ,  A61F2002/3895 ,  A61F2220/0033 ,  A61F2230/0034

    摘要： A modular prosthetic knee system used to replace the natural knee. The system includes a femoral knee prosthesis and a tibial knee prosthesis. Both prostheses are formed of modular components that are connectable in-vivo to form the prosthetic knee system. The femoral knee prosthesis includes two separate components, a lateral condyle and medial condyle; and the tibial knee prosthesis includes a multiple separate components, a medial baseplate, a lateral baseplate, a medial insert, and a lateral insert. The medial and lateral baseplate are connectable to form a complete baseplate with the medial and lateral inserts connectable to the complete baseplate.

    摘要翻译： 用于替代天然膝盖的模块化假肢膝盖系统。 该系统包括股骨膝假体和胫骨膝假体。 两个假体由可在体内连接以形成假体膝盖系统的模块化部件形成。 股骨膝假体包括两个单独的部件，一个外侧髁和内侧髁; 并且胫骨膝关节假体包括多个分开的部件，内侧基板，侧向基板，内侧插入物和侧向插入物。 内侧和外侧基板可连接成一个完整的底板，内侧和外侧插入件可连接到完整的底板上。

    Modular knee prosthesis
    2.
    发明授权
    Modular knee prosthesis 有权
    模块膝关节假体

    公开(公告)号：US07105026B2

    公开(公告)日：2006-09-12

    申请号：US11009498

    申请日：2004-12-10

    申请人： Erin M. Johnson ,  Joseph Saladino

    发明人： Erin M. Johnson ,  Joseph Saladino

    IPC分类号： A61F2/38

    CPC分类号： A61F2/3859 ,  A61F2/38 ,  A61F2/389 ,  A61F2002/30187 ,  A61F2002/30331 ,  A61F2002/30332 ,  A61F2002/3038 ,  A61F2002/30382 ,  A61F2002/30604 ,  A61F2002/30616 ,  A61F2002/30878 ,  A61F2002/30892 ,  A61F2002/30975 ,  A61F2002/3895 ,  A61F2220/0033 ,  A61F2230/0034

    摘要： A modular prosthetic knee system used to replace the natural knee. The system includes a femoral knee prosthesis and a tibial knee prosthesis. Both prostheses are formed of modular components that are connectable in-vivo to form the prosthetic knee system. The femoral knee prosthesis includes two separate components, a lateral condyle and medial condyle; and the tibial knee prosthesis includes a multiple separate components, a medial baseplate, a lateral baseplate, a medial insert, and a lateral insert. The medial and lateral baseplate are connectable to form a complete baseplate with the medial and lateral inserts connectable to the complete baseplate.

    摘要翻译： 用于替代天然膝盖的模块化假肢膝盖系统。 该系统包括股骨膝假体和胫骨膝假体。 两个假体由可在体内连接以形成假体膝盖系统的模块化部件形成。 股骨膝假体包括两个单独的部件，一个外侧髁和内侧髁; 并且胫骨膝关节假体包括多个分开的部件，内侧基板，侧向基板，内侧插入物和侧向插入物。 内侧和外侧基板可连接成一个完整的底板，内侧和外侧插入件可连接到完整的底板上。

    Modular knee prosthesis
    6.
    发明授权
    Modular knee prosthesis 有权
    模块膝关节假体

    公开(公告)号：US07527650B2

    公开(公告)日：2009-05-05

    申请号：US11870598

    申请日：2007-10-11

    申请人： Erin M. Johnson ,  Joseph Saladino

    发明人： Erin M. Johnson ,  Joseph Saladino

    IPC分类号： A61F2/38

    CPC分类号： A61F2/3859 ,  A61F2/38 ,  A61F2/389 ,  A61F2002/30187 ,  A61F2002/30331 ,  A61F2002/30332 ,  A61F2002/3038 ,  A61F2002/30382 ,  A61F2002/30604 ,  A61F2002/30616 ,  A61F2002/30878 ,  A61F2002/30892 ,  A61F2002/30975 ,  A61F2002/3895 ,  A61F2220/0033 ,  A61F2230/0034

    摘要： A modular knee system having various distal posterior femoral components that are interchangeable with each other and with various patellar-femoral joint components. Preferably, the modular knee system has a variety of components that are interchangeable and connectable to resurface the distal femur using either a unicompartmental femoral knee prosthesis or a bicompartmental femoral knee prosthesis. These components include a medial distal posterior femoral component, a lateral distal posterior femoral component, a patellar-femoral joint component, and an interconnection mechanism to modularly connect the components together.

    摘要翻译： 具有各种远端后股骨组件的模块化膝关节系统，其彼此可互换并具有各种髌骨 - 股骨关节部件。 优选地，模块化膝盖系统具有可互换且可连接的多种部件，以使用单室股骨膝关节假体或双室股骨膝关节假体来重建远端股骨。 这些部件包括内侧远端后股骨部件，侧向远端后股骨部件，髌骨 - 股骨关节部件以及将部件模块化地连接在一起的互连机构。

    Orthopaedic holding forceps
    7.
    发明授权
    Orthopaedic holding forceps 失效
    骨科手术钳

    公开(公告)号：US5391181A

    公开(公告)日：1995-02-21

    申请号：US141769

    申请日：1993-10-22

    申请人： Erin M. Johnson ,  Mark A. Lazzeri

    发明人： Erin M. Johnson ,  Mark A. Lazzeri

    IPC分类号： A61B17/28 ,  A61B17/88 ,  A61B17/00

    CPC分类号： A61B17/282 ,  A61B17/8894

    摘要： An orthopaedic holding forceps 1 for simultaneously holding a screw 60 and a screwdriver 70. The forceps 1 includes a distal tip 42 having an upper chamber 43 adapted for receiving an enlarged gripping head 72 of the screwdriver 70 and a lower chamber 44 adapted for receiving the enlarged head 61 of screw 60. The distal tip 42 also includes an interconnecting chamber 45 between the upper and lower chambers 43 and 44 adapted for receiving the distal driving tip 73 of the screwdriver 70.

    摘要翻译： 用于同时保持螺钉60和螺丝刀70的整形外科夹持钳1.镊子1包括具有适于容纳螺丝刀70的扩大夹头72的上室43的远侧末端42和适于接收螺丝刀70的下室44。 螺钉60的扩大头61.远侧末端42还包括适于容纳螺丝刀70的远侧驱动尖端73的上下腔室43和44之间的互连腔室45。

    MICROPARTICLE COMPOSITIONS TO MODIFY CANCER PROMOTING CELLS
    8.
    发明申请
    MICROPARTICLE COMPOSITIONS TO MODIFY CANCER PROMOTING CELLS 审中-公开
    微生物组合物修饰癌细胞

    公开(公告)号：US20090215729A1

    公开(公告)日：2009-08-27

    申请号：US12389325

    申请日：2009-02-19

    申请人： Erin M. Johnson ,  Mark E. Johnson

    发明人： Erin M. Johnson ,  Mark E. Johnson

    IPC分类号： A61K31/663 ,  A61P35/00

    CPC分类号： A61K9/143 ,  A61K9/5115

    摘要： This invention provides pharmaceutical compositions and methods related to the prevention and treatment of primary tumors and metastatic, malignant or spreading cancers by selectively targeting cancer associated myeloid derived cells by the targeted delivery of a bisphosphonate formulated with a non-liposomal particle carrier. In some aspects, the bisphosphonate particles have one or more properties suitable for phagocytosis by cancer associated myeloid derived cells and release of the bisphosphonate within the macrophages. Advantageously, administering the particles to a subject reduces the level and/or activity of cancer associated myeloid derived cells in the subject.

    摘要翻译： 本发明提供了通过靶向递送用非脂质体颗粒载体配制的双膦酸盐选择性地靶向癌相关骨髓来源的细胞来预防和治疗原发性肿瘤和转移性，恶性或扩散性癌症的药物组合物和方法。 在一些方面，双膦酸盐颗粒具有一种或多种适用于癌相关骨髓衍生细胞的吞噬作用和在巨噬细胞内双膦酸盐释放的性质。 有利地，向受试者施用颗粒降低了受试者中癌相关骨髓衍生细胞的水平和/或活性。