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17 条记录 (耗时 0.036 秒)

    Inhibition of cell migration with synthetic peptides
    1.
    发明授权
    Inhibition of cell migration with synthetic peptides 失效
    用合成肽抑制细胞迁移

    公开(公告)号：US5547936A

    公开(公告)日：1996-08-20

    申请号：US169743

    申请日：1993-12-17

    申请人： Erkki I. Ruoslahti ,  Michael D. Pierschbacher ,  Kurt R. Gehlsen

    发明人： Erkki I. Ruoslahti ,  Michael D. Pierschbacher ,  Kurt R. Gehlsen

    IPC分类号： A61K38/07 ,  A61K38/08 ,  A61L27/22 ,  C07K14/78 ,  A61K38/04 ,  A61K38/16

    CPC分类号： C07K14/78 ,  A61K38/07 ,  A61K38/08 ,  A61L27/227

    摘要： A method of inhibiting the invasion of cells, particularly malignant cells through an extracellular membrane by contacting the membrane-cell interface with synthetic Arg-Gly-Asp-containing peptides. In one embodiment, the invention provides peptides containing the amino acid sequence Arg-Gly-Asp-Thr, more specifically Gly-Arg-Gly-Asp-Thr-Pro, which inhibits the attachment of cells to type I collagen in addition to fibronectin and vitronectin, and a method of inhibiting the attachment of cells to type I collagen. The invention further provides an assay for quantitating the invasive quality of cells by determining the amount of such peptides necessary to prevent the cells from penetrating an extracellular membrane, such as an amniotic membrane, in vitro.

    摘要翻译： 通过使膜 - 细胞界面与合成的含有Arg-Gly-Asp的合成肽接触来抑制细胞侵入的方法，特别是恶性细胞通过细胞外膜。 在一个实施方案中，本发明提供了含有氨基酸序列Arg-Gly-Asp-Thr，更特别地Gly-Arg-Gly-Asp-Thr-Pro的肽，其除了纤连蛋白以外还抑制细胞与I型胶原的连接， 玻连蛋白，以及抑制细胞对I型胶原的附着的方法。 本发明进一步提供了一种用于通过确定在体外测定防止细胞穿透细胞外膜（例如羊膜）所必需的这种肽的量来量化细胞侵入性质量的测定法。

    Adhesion receptor for laminin and its use
    2.
    发明授权
    Adhesion receptor for laminin and its use 失效
    层粘连蛋白的粘附受体及其用途

    公开(公告)号：US5180809A

    公开(公告)日：1993-01-19

    申请号：US357354

    申请日：1989-05-25

    申请人： Erkki I. Ruoslahti ,  Eva Engvall ,  Kurt R. Gehlsen

    发明人： Erkki I. Ruoslahti ,  Eva Engvall ,  Kurt R. Gehlsen

    IPC分类号： C07K14/705 ,  C07K16/28

    CPC分类号： C07K16/2839 ,  C07K14/70546 ,  Y10S530/81

    摘要： An adhesion receptor for laminin is provided. The receptor is isolated from cell or tissue extracts and fractionated on an affinity column composed of cell attachment-promoting fragments of laminin coupled to Sepharose.TM. in the presence of divalent cations. This receptor can be used to prepare specific antibodies for the analysis of the amount of laminin receptor expressed by cells and has other applications in cellular and tumor biology.

    摘要翻译： 提供层粘连蛋白的粘附受体。 该受体与细胞或组织提取物分离，并在由二价阳离子存在下与Sepharose TM偶联的层粘连蛋白的细胞附着促进片段组成的亲和柱上分级分离。 该受体可用于制备用于分析由细胞表达的层粘连蛋白受体的量的特异性抗体，并且在细胞和肿瘤生物学中具有其它应用。

    Treatment and prevention of reactive oxygen metabolite-mediated cellular damage
    6.
    发明授权
    Treatment and prevention of reactive oxygen metabolite-mediated cellular damage 失效
    治疗和预防活性氧代谢物介导的细胞损伤

    公开(公告)号：US06242473B1

    公开(公告)日：2001-06-05

    申请号：US09227455

    申请日：1999-01-08

    申请人： Kristoffer Hellstrand ,  Svante Hermodsson ,  Kurt R. Gehlsen

    发明人： Kristoffer Hellstrand ,  Svante Hermodsson ,  Kurt R. Gehlsen

    IPC分类号： A61K31417

    CPC分类号： A61K45/06 ,  A61K31/00 ,  A61K31/33 ,  A61K31/4045 ,  A61K31/417 ,  A61K2300/00

    摘要： The present invention relates to a method for preventing and/or reducing cellular and tissue damage caused by reactive oxygen metabolites (ROMs) released by phagocytic or endothelial cells in response to various disease states or pathologies. The methods of the present invention are useful in preventing and treating a variety of disease states or pathological situations in which ROMs are produced and released. The methods of the present invention contemplate reducing ROM-mediated damage by reducing the production and release of ROMs.

    摘要翻译： 本发明涉及一种预防和/或减少由于吞噬或内皮细胞响应于各种疾病状态或病理释放的活性氧代谢物（ROM）引起的细胞和组织损伤的方法。 本发明的方法可用于预防和治疗其中产生和释放ROM的各种疾病状态或病态。 本发明的方法考虑通过减少ROM的产生和释放来减少ROM介导的损伤。

    Elevation of circulating blood histamine levels
    10.
    发明授权
    Elevation of circulating blood histamine levels 失效
    循环血液组胺水平升高

    公开(公告)号：US06613788B1

    公开(公告)日：2003-09-02

    申请号：US09526816

    申请日：2000-03-15

    申请人： Kristoffer Hellstrand ,  Svante Hermodsson ,  Kurt R. Gehlsen

    发明人： Kristoffer Hellstrand ,  Svante Hermodsson ,  Kurt R. Gehlsen

    IPC分类号： A61K970

    CPC分类号： A61K45/06 ,  A61K31/417

    摘要： Methods for obtaining beneficial stable levels of circulating histamine are disclosed for use in methods for enhancing natural killer cell cytotoxicity and for elevating histamine levels in individuals in need thereof. In such methods, a beneficial level of circulating histamine is attained and an agent whose ability to enhance natural killer cell cytotoxicity is augmented by histamine is administered. Alternatively, stable beneficial levels of circulating histamine can be attained in subjects receiving chemotherapy or antiviral treatment. The invention may also be employed in treatments combining histamine, agents which enhance natural killer cell cytotoxicity, and chemotherapeutic agents. Optimization of the delivery of histamine and substances which induce the release of endogenous histamine are also disclosed.

    摘要翻译： 公开了用于获得有益的稳定水平的循环组胺的方法用于增强天然杀伤细胞细胞毒性的方法和提高有需要的个体中的组胺水平。 在这样的方法中，获得循环组胺的有益水平，并且施用通过组胺增强其增强自然杀伤细胞细胞毒性的能力的药剂。 或者，可以在接受化疗或抗病毒治疗的受试者中获得稳定的有益水平的循环组胺。 本发明还可以用于组合组胺，增强自然杀伤细胞细胞毒性的药剂和化学治疗剂的治疗。 还公开了诱导内源组胺释放的组胺和物质的递送的优化。