公开(公告)号：US20220062492A1

公开(公告)日：2022-03-03

申请号：US17007712

申请日：2020-08-31

Applicant: Ethicon, Inc.

Inventor： THOMAS Weindl ,  Xuejun Jay Liu ,  Gerard Llanos ,  Yi-Lan Allen Wang ,  Wilai Kosol

IPC: A61L15/22 ,  B32B27/08 ,  A61L15/64 ,  A61L15/18 ,  A61L15/32

Abstract: The present invention is directed to multi-layered wound dressings having a carrier layer, at least two sublayers, wherein each sublayer contains at least one reactive, cross-linkable component and the at least two reactive, cross-linkable components are co-reactive with the other and at least one reactive, cross-linkable has a protective leaving group and a buffering salt agent.

公开(公告)号：US20220023491A1

公开(公告)日：2022-01-27

申请号：US16934998

申请日：2020-07-21

Applicant: Ethicon, Inc.

Inventor： Yi-Lan Allen Wang ,  Jerry Yan ,  Leo B. Kriksunov

IPC: A61L26/00

Abstract: The present invention relates to a hemostatic absorbable composition, comprising: a flowable plurality of separate aggregates each comprising: a plurality of absorbable carrier particles coated on a surface thereof by a plurality of smaller particles comprising an absorbable supplemental hemostasis-promoting agent. In some embodiments, the absorbable carrier particles comprise gelatin or collagen, and the supplemental hemostasis-promoting agent comprises oxidized cellulose, oxidized regenerated cellulose, carboxylic oxidized cellulose, carboxylic oxidized regenerated cellulose, thrombin, or tranexamic acid.

公开(公告)号：US12285540B2

公开(公告)日：2025-04-29

申请号：US16934998

申请日：2020-07-21

Applicant: Ethicon, Inc.

Inventor： Yi-Lan Allen Wang ,  Jerry Yan ,  Leo B. Kriksunov

IPC: A61L26/00

Abstract: The present invention relates to a hemostatic absorbable composition, comprising: a flowable plurality of separate aggregates each comprising: a plurality of absorbable carrier particles coated on a surface thereof by a plurality of smaller particles comprising an absorbable supplemental hemostasis-promoting agent. In some embodiments, the absorbable carrier particles comprise gelatin or collagen, and the supplemental hemostasis-promoting agent comprises oxidized cellulose, oxidized regenerated cellulose, carboxylic oxidized cellulose, carboxylic oxidized regenerated cellulose, thrombin, or tranexamic acid.

公开(公告)号：US20210038757A1

公开(公告)日：2021-02-11

申请号：US16945990

申请日：2020-08-03

Applicant: Omrix Biopharmaceuticals Ltd. ,  Ethicon, Inc.

Inventor： EREZ ILAN ,  OMRI FAINGOLD ,  TAMAR AUERBACH-NEVO ,  TALI NEGREANU-GILBOA ,  HADAS ALPERIN ,  Yi-Lan Allen Wang ,  Dwayne Looney

IPC: A61L15/28 ,  A61L15/42 ,  A61L15/64 ,  A61L15/44

Abstract: An expandable biodegradable hemostatic matrix comprised of oxidized cellulose, and having a density ranging from about 0.8 to about 1.2 gr/cm3 is disclosed herein. The matrix may be expandable to at least 3 times its original volume within 4 sec upon contact with an aqueous solution room temperature. Further disclosed are methods for making the hemostatic matrix as well as method of treating a wound.