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公开(公告)号：US20220331475A1
公开(公告)日：2022-10-20
申请号：US17667787
申请日：2022-02-09
Applicant: Ethicon, Inc.
Inventor： Nir Nativ , Thomas Weindl , Benjamin D. Fitz , Gerard Llanos , Guanghui Zhang , Yi-Lan Wang , Meng Deng
Abstract: The present invention is directed to a hemostatic patch comprising a porous substrate and at least a pair of co-reactive polymer reagents comprising at least one nucleophilic polyalkylene oxide based component and at least one electrophilic polyalkylene oxide-based on the porous substrate in a molar ratio of about 0.2 to about 0.9:1 of primary nucleophilic groups in excess to available electrophilic groups. The present invention is also directed to processes for the manufacture and use of such hemostatic patches.
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公开(公告)号：US20220023488A1
公开(公告)日：2022-01-27
申请号：US16934982
申请日：2020-07-21
Applicant: Ethicon, Inc.
Inventor： Nir Nativ , Gerard Llanos , Thomas Weindl , Sai Veruva
Abstract: The present invention is directed to medical devices having a first porous substrate layer with at least a surface coating thereon of a first co-reactive component and a second substrate layer with at least a surface coating layer of a second co-reactive component that reacts with the first co-reactive component, and a removable barrier layer positioned between the first substrate layer and second substrate layer and in contact with said first substrate layer and said second substrate layer.
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公开(公告)号：US20250108142A1
公开(公告)日：2025-04-03
申请号：US18374019
申请日：2023-09-28
Applicant: Ethicon, Inc.
Inventor： Degang Zhong , Gerard Llanos , Jianguo Jack Zhou
IPC: A61L24/04 , A61K31/192 , A61K31/496
Abstract: Disclosed herein are flowable biocompatible sealant compositions in the form of a biodegradable cross-linked gel, comprised of an insoluble agent for preventing infection, and an agent for preventing ischemia, wherein the agent for preventing ischemia is embedded in polymeric microparticles. The composition is characterized in that it releases at least part of said agents in a sustained manner. Uses of the compositions in methods for treating a leakage from a gastrointestinal site are further disclosed.
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公开(公告)号：US12102722B2
公开(公告)日：2024-10-01
申请号：US16895150
申请日：2020-06-08
Applicant: Ethicon, Inc.
Inventor： Sai Veruva , Jianguo Zhou , Joseph Vliet , Gerard Llanos
IPC: A61L15/22 , A61F13/00 , A61F13/15 , A61L15/32 , A61L15/42 , A61L15/44 , A61L15/64 , B29C48/00 , B29L31/00
CPC classification number: A61L15/225 , A61F13/00063 , A61L15/32 , A61L15/425 , A61L15/44 , A61L15/64 , A61F2013/00676 , A61F2013/00863 , A61F2013/15967 , A61L2300/254 , A61L2300/43 , A61L2400/04 , B29C48/0018 , B29K2995/006 , B29L2031/753
Abstract: The present invention is directed to an absorbable hemostatic patch that utilizes a biocompatible fibrous, fabric substrate that is melt-blown and napped or loosened at the surface, with the substrate having a low-profile, high flexibility, strength and porosity that is suitable for coating cross-linkable active molecules and ultimately effective for use as a hemostat in situations of problematic bleeding.
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公开(公告)号：US20220062492A1
公开(公告)日：2022-03-03
申请号：US17007712
申请日：2020-08-31
Applicant: Ethicon, Inc.
Inventor： THOMAS Weindl , Xuejun Jay Liu , Gerard Llanos , Yi-Lan Allen Wang , Wilai Kosol
Abstract: The present invention is directed to multi-layered wound dressings having a carrier layer, at least two sublayers, wherein each sublayer contains at least one reactive, cross-linkable component and the at least two reactive, cross-linkable components are co-reactive with the other and at least one reactive, cross-linkable has a protective leaving group and a buffering salt agent.
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Patent Agency Ranking
公开(公告)号：US20210252185A1
公开(公告)日：2021-08-19
申请号：US16793104
申请日：2020-02-18
Applicant: Ethicon, Inc.
Inventor： Sai Veruva , Jianguo Zhou , Joseph Vliet , Gerard Llanos , Kenneth Keilman
Abstract: The present invention is directed to an absorbable hemostatic nonwoven patch that utilizes a biocompatible substrate comprised of melt-blown microfibers as webbed sheets that are layered and bonded/entangled in descending density and ascending porosity; with the substrate having a high flexibility, strength and porosity that is suitable for coating cross-linkable active molecules and ability for laparoscopic use or trocar deployment, ultimately for functional use as a highly effective hemostat in addressing problematic bleeding during both open and minimally invasive surgical procedures.
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公开(公告)号：US20150238366A1
公开(公告)日：2015-08-27
申请号：US14707559
申请日：2015-05-08
Applicant: Ethicon, Inc.
Inventor： Aaron D. Pesnell , Gerard Llanos
CPC classification number: A61F13/00995 , A61K38/363 , A61K38/4833 , A61L15/26 , A61L15/28 , A61L15/32 , A61L15/42 , A61L15/64 , A61L2300/418 , A61L2400/04 , B05D1/02 , B05D1/18 , C08L71/02 , A61K2300/00 , C08L1/28 , C08L67/04
Abstract: A hemostatic pad comprising a bioabsorbable scaffolding material; a lyophilized thrombin powder, a lyophilized fibrinogen powder, and a meltable binder powder, with all powders disposed on the bioabsorbable scaffolding material. A meltable binder such as PEG bonds the lyophilized thrombin powder and the lyophilized fibrinogen powder to the bioabsorbable scaffolding material for improved friability, wettability and performance in a use, such as for hemostatic treatment or sealing at a wound site.
Abstract translation: 一种止血垫，包括生物可吸收的脚手架材料; 冻干的凝血酶粉末，冻干的纤维蛋白原粉末和可熔融的粘合剂粉末，其中所有粉末都设置在生物可吸收的脚手架材料上。 可熔融粘合剂如PEG将冻干的凝血酶粉末和冻干的纤维蛋白原粉末粘合到生物可吸收的脚手架材料上，以提高使用中的脆性，润湿性和性能，例如在伤口部位进行止血治疗或密封。
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公开(公告)号：US20240399018A1
公开(公告)日：2024-12-05
申请号：US18783527
申请日：2024-07-25
Applicant: Ethicon, Inc.
Inventor： Sai Veruva , Jianguo Zhou , Joseph Vliet , Gerard Llanos , Kenneth Keilman
Abstract: The present invention is directed to an absorbable hemostatic nonwoven patch that utilizes a biocompatible substrate comprised of melt-blown microfibers as webbed sheets that are layered and bonded/entangled in descending density and ascending porosity; with the substrate having a high flexibility, strength and porosity that is suitable for coating cross-linkable active molecules and ability for laparoscopic use or trocar deployment, ultimately for functional use as a highly effective hemostat in addressing problematic bleeding during both open and minimally invasive surgical procedures.
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9.发明授权公开(公告)号：US08697193B2
公开(公告)日：2014-04-15
申请号：US13775761
申请日：2013-02-25
Applicant: Ethicon, Inc.
Inventor： Clifford Dey , Markus Bohn , Hans-Steffen Schacht , Ashley P. DeAnglis , Robert W. Van Holten , Dwayne Looney , Gerard Llanos , Avner Brandes
Abstract: An engagement head for engaging a porous substrate includes at least two pin sets, each pin set including a plurality of pins arranged in a plurality of parallel pin rows at a predetermined pin angle, wherein pins of immediately neighboring pin rows are arranged such that pin angles for the pins in a pin row are inversely symmetrical to pin angles for the pins in a neighboring pin row. The pins of a pin row move collectively in the same direction when a pin set is extended, which direction is determined by the pin angle of the pin row, whereby neighboring pin rows move in opposite longitudinal directions from one another when the pin set is extended. The pin sets may be extended and retracted in unison by a single actuation source.
Abstract translation: 用于接合多孔基材的接合头包括至少两个销组，每个销组包括以预定销角布置在多个平行销列中的多个销，其中紧邻相邻销列的销布置成使得销角 因为引脚列中的引脚与相邻引脚列中引脚的引脚角度成反向对称。 当销组延伸时，销排的销钉以相同的方向共同移动，该方向由销列的销角确定，由此当销组延伸时相邻的销列彼此相反的纵向方向移动 。 销组可以通过单个致动源一致地延伸和缩回。
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公开(公告)号：US12070522B2
公开(公告)日：2024-08-27
申请号：US16793104
申请日：2020-02-18
Applicant: Ethicon, Inc.
Inventor： Sai Veruva , Jianguo Zhou , Joseph Vliet , Gerard Llanos , Kenneth Keilman
CPC classification number: A61L15/60 , A61F13/00063 , A61L15/225 , A61F2013/00604 , A61F2013/00676 , A61F2013/00863 , A61F2013/15357 , A61F2013/15967
Abstract: An absorbable hemostatic nonwoven patch utilizes a biocompatible substrate comprised of melt-blown microfibers as webbed sheets that are layered and bonded/entangled in descending density and ascending porosity; the substrate having a high flexibility, strength and porosity that is suitable for coating cross-linkable active molecules and ability for laparoscopic use or trocar deployment, ultimately for functional use as a highly effective hemostat in addressing problematic bleeding during both open and minimally invasive surgical procedures.
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