公开(公告)号：US20130059318A1

公开(公告)日：2013-03-07

申请号：US13519696

申请日：2010-12-28

申请人： Etsuji Kaneko ,  Yuka Sasaki ,  Katsuhiro Mori ,  Yutaka Kanda ,  Mitsuo Satoh

发明人： Etsuji Kaneko ,  Yuka Sasaki ,  Katsuhiro Mori ,  Yutaka Kanda ,  Mitsuo Satoh

IPC分类号： C07K16/42 ,  C12N5/12 ,  C12N15/63 ,  G01N33/577 ,  C12N1/19 ,  C12N5/10 ,  C12P21/08 ,  C12N15/13 ,  C12N1/21

CPC分类号： C07K16/4283 ,  C07K2317/34 ,  C07K2317/92 ,  G01N2800/34

摘要： An object of the present invention is to provide a monoclonal antibody which is effective for diagnosing IgA nephropathy and specifically recognizes and binds to a hinge region of a polypeptide encoded by a heavy chain gene of immunoglobulin A1 that comprises a serine/threonine-linked sugar chain to which galactose is not bound. According to the present invention, it is possible to provide a monoclonal antibody or an antibody fragment thereof that specifically recognizes and binds to a hinge region of a polypeptide encoded by a heavy chain gene of immunoglobulin A1 that comprises a serine/threonine-linked sugar chain to which galactose is not bound, to provide a diagnostic agent using the antibody or the antibody fragment thereof, and to provide a therapeutic agent comprising the antibody or the antibody fragment thereof as an active ingredient.

摘要翻译： 本发明的目的是提供一种单克隆抗体，该单克隆抗体对于诊断IgA肾病是有效的，并特异性识别并结合由包含丝氨酸/苏氨酸连接的糖链的免疫球蛋白A1的重链基因编码的多肽的铰链区 半乳糖不结合。 根据本发明，可以提供特异性识别并结合由包含丝氨酸/苏氨酸连接的糖链的免疫球蛋白A1的重链基因编码的多肽的铰链区的单克隆抗体或其抗体片段 使用抗体或其抗体片段提供诊断剂，并提供包含抗体或其抗体片段的治疗剂作为活性成分。