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    ANTI-IGA1 ANTIBODY
    1.
    发明申请
    ANTI-IGA1 ANTIBODY 审中-公开
    ANTI-IGA1抗体

    公开(公告)号：US20130059318A1

    公开(公告)日：2013-03-07

    申请号：US13519696

    申请日：2010-12-28

    申请人： Etsuji Kaneko ,  Yuka Sasaki ,  Katsuhiro Mori ,  Yutaka Kanda ,  Mitsuo Satoh

    发明人： Etsuji Kaneko ,  Yuka Sasaki ,  Katsuhiro Mori ,  Yutaka Kanda ,  Mitsuo Satoh

    IPC分类号： C07K16/42 ,  C12N5/12 ,  C12N15/63 ,  G01N33/577 ,  C12N1/19 ,  C12N5/10 ,  C12P21/08 ,  C12N15/13 ,  C12N1/21

    CPC分类号： C07K16/4283 ,  C07K2317/34 ,  C07K2317/92 ,  G01N2800/34

    摘要： An object of the present invention is to provide a monoclonal antibody which is effective for diagnosing IgA nephropathy and specifically recognizes and binds to a hinge region of a polypeptide encoded by a heavy chain gene of immunoglobulin A1 that comprises a serine/threonine-linked sugar chain to which galactose is not bound. According to the present invention, it is possible to provide a monoclonal antibody or an antibody fragment thereof that specifically recognizes and binds to a hinge region of a polypeptide encoded by a heavy chain gene of immunoglobulin A1 that comprises a serine/threonine-linked sugar chain to which galactose is not bound, to provide a diagnostic agent using the antibody or the antibody fragment thereof, and to provide a therapeutic agent comprising the antibody or the antibody fragment thereof as an active ingredient.

    摘要翻译： 本发明的目的是提供一种单克隆抗体，该单克隆抗体对于诊断IgA肾病是有效的，并特异性识别并结合由包含丝氨酸/苏氨酸连接的糖链的免疫球蛋白A1的重链基因编码的多肽的铰链区 半乳糖不结合。 根据本发明，可以提供特异性识别并结合由包含丝氨酸/苏氨酸连接的糖链的免疫球蛋白A1的重链基因编码的多肽的铰链区的单克隆抗体或其抗体片段 使用抗体或其抗体片段提供诊断剂，并提供包含抗体或其抗体片段的治疗剂作为活性成分。

    Cells in which activity of the protein involved in transportation of GDP-fucose is reduced or lost
    3.
    发明授权
    Cells in which activity of the protein involved in transportation of GDP-fucose is reduced or lost 有权
    涉及GDP-岩藻糖运输的蛋白质活性降低或丧失的细胞

    公开(公告)号：US08361751B2

    公开(公告)日：2013-01-29

    申请号：US12782782

    申请日：2010-05-19

    申请人： Yutaka Kanda ,  Mitsuo Satoh ,  Katsuhiro Mori

    发明人： Yutaka Kanda ,  Mitsuo Satoh ,  Katsuhiro Mori

    IPC分类号： C12P21/08 ,  C12N5/10 ,  C12N5/0781

    CPC分类号： C12N15/8245 ,  A61K2039/505 ,  C07K14/47 ,  C07K16/18 ,  C07K16/2866 ,  C07K2317/24 ,  C07K2317/732

    摘要： A cell in which the activity of a protein relating to transport of an intracellular sugar nucleotide, GDP-fucose, to the Golgi body is more decreased or deleted than its parent cell; a process for producing an antibody composition using the cell; a transgenic non-human animal or plant or the progenies thereof, in which genome is modified so as to have a decreased or deleted activity of a protein relating to transport of an intracellular sugar nucleotide, GDP-fucose, to the Golgi body; a process for producing an antibody composition from the animal or plant; and a medicament comprising the antibody composition.

    摘要翻译： 与细胞内糖核苷酸GDP-岩藻糖转运到高尔基体相关的蛋白质的活性比其亲本细胞更多地减少或缺失的细胞; 使用该细胞产生抗体组合物的方法; 转基因非人动物或植物或其后代，其中基因组被修饰以具有与细胞内糖核苷酸GDP-岩藻糖转运到高尔基体相关的蛋白质的降低或缺失的活性; 从动物或植物制备抗体组合物的方法; 和包含该抗体组合物的药物。

    Anti-CD27 antibody
    4.
    发明授权
    Anti-CD27 antibody 有权
    抗CD27抗体

    公开(公告)号：US09023999B2

    公开(公告)日：2015-05-05

    申请号：US12494827

    申请日：2009-06-30

    申请人： Katsuhiro Mori ,  Naoko Hiura ,  Tsuguo Kubota ,  Akiko Furuya ,  Yutaka Kanda ,  Mitsuo Satoh

    发明人： Katsuhiro Mori ,  Naoko Hiura ,  Tsuguo Kubota ,  Akiko Furuya ,  Yutaka Kanda ,  Mitsuo Satoh

    IPC分类号： C07K16/00 ,  C12P19/00 ,  G01N33/53 ,  G01N33/574 ,  C07K16/28 ,  C12R1/91 ,  G01N33/68

    CPC分类号： G01N33/57484 ,  C07K16/2878 ,  C07K2317/24 ,  C07K2317/56 ,  C07K2317/565 ,  C07K2317/734 ,  C07K2317/92 ,  C12R1/91 ,  G01N33/6863 ,  G01N2333/70578 ,  G01N2400/02 ,  G01N2800/347

    摘要： The present invention provides a monoclonal antibody which specifically recognizes CD27 containing an O-linked sugar chain to which galactose is not bound and binds to its extracellular region, or a method for using the same.The present invention can provide a monoclonal antibody or an antibody fragment thereof, which specifically recognizes a polypeptide encoded by CD27 gene containing an O-linked sugar chain to which galactose is not bound, and binds to its extracellular region; a hybridoma which produces the antibody; a DNA which encodes the antibody; a vector which comprises the DNA; a transformant obtainable by transforming the vector; a process for producing an antibody or an antibody fragment thereof using the hybridoma or the transformant; and a diagnostic agent or a therapeutic agent comprising the antibody or the antibody fragment thereof as an active ingredient.

    摘要翻译： 本发明提供一种单克隆抗体，其特异性识别含有O-连接的糖链的CD27，其中半乳糖不结合并结合到其胞外区域，或其使用方法。 本发明可以提供一种单克隆抗体或其抗体片段，该单克隆抗体或其抗体片段特异性识别由含有O-连接的糖链的CD27基因编码的多肽，其中半乳糖未结合到其上并结合其胞外区域; 产生抗体的杂交瘤; 编码抗体的DNA; 包含DNA的载体; 通过转化载体可获得的转化体; 使用杂交瘤或转化体生产抗体或其抗体片段的方法; 以及包含该抗体或其抗体片段作为有效成分的诊断剂或治疗剂。

    Cells in which activity of the protein involved in transportation of GDP-fucose is reduced or lost
    5.
    发明授权
    Cells in which activity of the protein involved in transportation of GDP-fucose is reduced or lost 有权
    涉及GDP-岩藻糖运输的蛋白质活性降低或丧失的细胞

    公开(公告)号：US07749753B2

    公开(公告)日：2010-07-06

    申请号：US10409600

    申请日：2003-04-09

    申请人： Yutaka Kanda ,  Mitsuo Satoh ,  Katsuhiro Mori

    发明人： Yutaka Kanda ,  Mitsuo Satoh ,  Katsuhiro Mori

    IPC分类号： C12P21/02 ,  C07H21/04

    CPC分类号： C12N15/8245 ,  A61K2039/505 ,  C07K14/47 ,  C07K16/18 ,  C07K16/2866 ,  C07K2317/24 ,  C07K2317/732

    摘要： A cell in which the activity of a protein relating to transport of an intracellular sugar nucleotide, GDP-fucose, to the Golgi body is more decreased or deleted than its parent cell; a process for producing an antibody composition using the cell; a transgenic non-human animal or plant or the progenies thereof, in which genome is modified so as to have a decreased or deleted activity of a protein relating to transport of an intracellular sugar nucleotide, GDP-fucose, to the Golgi body; a process for producing an antibody composition from the animal or plant; and a medicament comprising the antibody composition.

    摘要翻译： 与细胞内糖核苷酸GDP-岩藻糖转运到高尔基体相关的蛋白质的活性比其亲本细胞更多地减少或缺失的细胞; 使用该细胞产生抗体组合物的方法; 转基因非人动物或植物或其后代，其中基因组被修饰以具有与细胞内糖核苷酸GDP-岩藻糖转运到高尔基体相关的蛋白质的降低或缺失的活性; 从动物或植物制备抗体组合物的方法; 和包含该抗体组合物的药物。

    Process for producing glycoprotein composition
    6.
    发明申请
    Process for producing glycoprotein composition 审中-公开
    糖蛋白组合物的制备方法

    公开(公告)号：US20060223147A1

    公开(公告)日：2006-10-05

    申请号：US11196503

    申请日：2005-08-04

    申请人： Harue Nishiya ,  Mitsuo Satoh ,  Katsuhiro Mori

    发明人： Harue Nishiya ,  Mitsuo Satoh ,  Katsuhiro Mori

    IPC分类号： C12P19/28 ,  C07H21/04 ,  C12P21/06 ,  C12N9/04 ,  C12N9/10

    CPC分类号： C12P21/005 ,  C12N9/1051 ,  C12N9/88

    摘要： The present invention relates to a cell into which an RNA capable of suppressing the function of an enzyme catalyzing a reaction which converts GDP-mannose into GDP-4-keto,6-deoxy-GDP-mannose is introduced; a process for producing a glycoprotein using the cell; a cell into which an RNA capable of suppressing the function of an enzyme relating to modification of a sugar chain in which 1-position of fucose is bound to 6-position of N-acetylglucosamine in the reducing end through α-bond in the complex type N-glycoside-linked sugar chain, and an RNA capable of suppressing the function of an enzyme relating to synthesis of an intracellular sugar nucleotide, GDP-fucose, or an RNA capable of suppressing the function of a protein relating to transport of an intracellular sugar nucleotide, GDP-fucose, to the Golgi body are introduced; a process for producing a glycoprotein composition using the cell; and the like.

    摘要翻译： 本发明涉及能够抑制催化将GDP-甘露糖转化成GDP-4-酮，6-脱氧-GG-甘露糖的反应的酶的功能的RNA的细胞; 使用该细胞产生糖蛋白的方法; 能够抑制与糖链的修饰相关的酶的功能的RNA的细胞，其中岩藻糖的1位通过复合型中的α-键与还原末端的N-乙酰葡糖胺的6-位结合 N-糖苷连接的糖链，以及能够抑制与胞内糖核苷酸GDP-岩藻糖合成相关的酶的功能的RNA，或能够抑制与细胞内糖的运输有关的蛋白质的功能的RNA 核苷酸，GDP-岩藻糖，到高尔基体; 使用该细胞产生糖蛋白组合物的方法; 等等。

    Process for producing antibody composition by using rna inhibiting the function of alpha1,6-fucosyltransferase
    8.
    发明申请
    Process for producing antibody composition by using rna inhibiting the function of alpha1,6-fucosyltransferase 审中-公开
    通过使用抑制α1,6-岩藻糖基转移酶功能的rna产生抗体组合物的方法

    公开(公告)号：US20070134759A1

    公开(公告)日：2007-06-14

    申请号：US10575096

    申请日：2004-10-08

    申请人： Harue Nishiya ,  Mitsuo Satoh ,  Katsuhiro Mori

    发明人： Harue Nishiya ,  Mitsuo Satoh ,  Katsuhiro Mori

    IPC分类号： C07K16/40 ,  C07H21/04 ,  C12P21/06 ,  C12N9/10

    CPC分类号： C12N15/1137 ,  C07K16/00 ,  C07K2317/72 ,  C12N2310/111 ,  C12N2310/14 ,  C12Y204/01068

    摘要： The present invention provides a process for producing an antibody composition using a cell, which comprises using a cell into which an RNA having activity of suppressing the function of an enzyme relating to the modification of a sugar chain in which 1-position of fucose is bound to 6-position of N-acetylglucosamine in the reducing end through α-bond in a complex type N-glycoside-linked sugar chain is introduced; the RNA used in the production process; a DNA corresponding to the RNA; a cell in which the RNA or DNA is introduced or expressed; a process for producing the cell; and a method for suppressing the enzyme.

    摘要翻译： 本发明提供一种使用细胞的抗体组合物的制造方法，其包括使用具有抑制与其中1位的岩藻糖结合的糖链的修饰相关的酶的功能的活性的RNA的细胞 通过复合型N-糖苷连接的糖链中的α-键引入还原末端的N-乙酰葡糖胺的6-位; 生产过程中使用的RNA; 对应于RNA的DNA; 引入或表达RNA或DNA的细胞; 一种生产细胞的方法; 和抑制酶的方法。

    Method of producing coated lenses
    10.
    发明授权
    Method of producing coated lenses 有权
    生产涂层镜片的方法

    公开(公告)号：US08613982B2

    公开(公告)日：2013-12-24

    申请号：US12516740

    申请日：2008-01-25

    申请人： Naoto Takahashi ,  Katsuhiro Mori ,  Noriyuki Fukada

    发明人： Naoto Takahashi ,  Katsuhiro Mori ,  Noriyuki Fukada

    IPC分类号： C08J7/04 ,  C08F2/48

    CPC分类号： B05D1/005 ,  B05D3/067 ,  B05D5/061

    摘要： A method of coating without permitting the coating solution to flow onto the side surfaces or the back surfaces of the lenses in the operation for applying the coating solution onto the lenses. A lens 15 is spin-coated with the coating solution having a particular viscosity. A side edge portion 121 of a spatula 119 is brought into contact with an upper edge portion of a side surface 15a of the lens 15 before the coating solution fed onto the surface of the lens arrives at the peripheral edge portion of the lens. The side edge portion 121 of the spatula 119 is so arranged that the upper end side of the spatula is tilted toward the center side of the lens 15 at an angle of 5 to 35 degrees with the vertical line as a reference. The coating solution applied onto the lens 15 that is rotating adheres onto the spatula 119 but does not adhere onto the side surface of the lens 15.

    摘要翻译： 在涂布溶液到透镜的操作中，涂布方法不允许涂布溶液流到透镜的侧表面或背面。 透镜15被涂覆有具有特定粘度的涂布溶液。 刮刀119的侧边缘部分121与透镜15的侧表面15a的上边缘部分接触，然后将馈送到透镜表面的涂布溶液到达透镜的周缘部分。 刮铲119的侧边缘部分121被布置成使得刮刀的上端侧以垂直线作为基准以5至35度的角度朝向透镜15的中心侧倾斜。 施加到正在旋转的透镜15上的涂布溶液粘附到刮刀119上，但不粘附到透镜15的侧表面上。