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公开(公告)号：US06670137B2
公开(公告)日：2003-12-30
申请号：US09892835
申请日：2001-06-27
IPC分类号： G01N3353
CPC分类号： G01N33/6896 , G01N2800/28 , G01N2800/2821 , G01N2800/2835
摘要： The present invention provides a method for the differential diagnosis of an individual suffering from Alzheimer's disease versus and individual suffering from another neurological disease. More specifically, the present invention provides a method for the differential diagnosis of an individual suffering from Alzheimer's disease versus an individual suffering from dementia with Lewy bodies, versus an individual suffering from Parkinson's disease without dementia, versus an individual suffering from multi-system atrophy and/or versus an individual suffering from progressive supranuclear palsy, said method characterized that phospho-tau is used as a neurological marker.
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2.发明授权Antibodies specific of the β-amyloid peptides and their uses as diagnostic agents or drugs 失效β-淀粉状蛋白肽特异性抗体及其用途作为诊断剂或药物公开(公告)号：US08343493B2
公开(公告)日：2013-01-01
申请号：US12740217
申请日：2008-10-24
申请人： Eugeen VanMechelen , Pierre Grognet , Nicolas Sergeant , Marie Gompel , Andre Delacourte , Luc Buee , Laurent Pradier , Veronique Blanchard-Bregeon
发明人： Eugeen VanMechelen , Pierre Grognet , Nicolas Sergeant , Marie Gompel , Andre Delacourte , Luc Buee , Laurent Pradier , Veronique Blanchard-Bregeon
IPC分类号： A61K39/395 , C12P21/08 , C07K16/18 , C12N5/20 , C12N5/12 , G01N33/533 , G01N33/534 , G01N33/535
CPC分类号： C07K16/18 , A61K2039/505 , C07K14/4711 , C07K2317/56 , C07K2317/565 , C07K2317/92
摘要： A monoclonal antibody which specifically binds to the N-terminal region of Aβ8-x peptide, x being included from 11 to 42, and recognizes neither Aβ1-40 nor Aβ1-42 and which presents a high affinity with respect to Aβ8-x peptide, such as determined by an immunological complex formation between the monoclonal antibody and the peptide Aβ8-x.
摘要翻译： 特异性结合A＆Bgr。8-x肽的N-末端区域的单克隆抗体，x包含在11至42中，并且既不识别A＆bgr; 1-40也不识别为1-42，并且与 至A-Bgr; 8-x肽，例如通过单克隆抗体和肽A和Bgr之间的免疫复合物形成确定8-x。
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