Persephin and related growth factors
    1.
    发明授权
    Persephin and related growth factors 有权
    Persephin及相关生长因子

    公开(公告)号:US06692943B1

    公开(公告)日:2004-02-17

    申请号:US09220527

    申请日:1998-12-24

    IPC分类号: C12P2104

    摘要: A novel growth factor, persephin, which belongs to the GDNF/neurturin family of growth factors, is disclosed. The mouse and rat amino acid sequences have been identified. Mouse and rat persephin genomic DNA sequences have been cloned and sequenced and the respective cDNA sequences identified. In addition, methods for treating degenerative conditions using persephin, methods for detecting persephin gene alterations and methods for detecting and monitoring patient levels of persephin are provided. Methods for identifying additional members of the persephin-neurturin-GDNF family of growth factors are also provided.

    摘要翻译: 公开了属于GDNF / neurturin生长因子家族的新生长因子persephin。 已经鉴定了小鼠和大鼠的氨基酸序列。 已经克隆并测序了小鼠和大鼠persephin基因组DNA序列,并鉴定了各自的cDNA序列。 此外,还提供了使用persephin治疗退行性病症的方法,用于检测persephin基因改变的方法以及用于检测和监测患者血浆含量的方法。 还提供了用于鉴定生长因子的persephin-neurturin-GDNF家族的额外成员的方法。

    Polynucleotides encoding persephin and related growth factors
    2.
    发明授权
    Polynucleotides encoding persephin and related growth factors 失效
    编码persephin和相关生长因子的多核苷酸

    公开(公告)号:US06403335B1

    公开(公告)日:2002-06-11

    申请号:US09128026

    申请日:1998-07-31

    IPC分类号: C12N1518

    摘要: A novel growth factor, persephin, which belongs to the GDNF/neurturin family of growth factors, is disclosed. The mouse and rat amino acid sequences have been identified. Mouse and rat persephin genomic DNA sequences have been cloned and sequenced and the respective cDNA sequences identified. In addition, methods for treating degenerative conditions using persephin, methods for detecting persephin gene alterations and methods for detecting and monitoring patient levels of persephin are provided. Methods for identifying additional members of the persephin-neurturin-GDNF family of growth factors are also provided.

    摘要翻译: 公开了属于GDNF / neurturin生长因子家族的新生长因子persephin。 已经鉴定了小鼠和大鼠的氨基酸序列。 已经克隆并测序了小鼠和大鼠persephin基因组DNA序列,并鉴定了各自的cDNA序列。 此外,还提供了使用persephin治疗退行性病症的方法,用于检测persephin基因改变的方法以及用于检测和监测患者血浆含量的方法。 还提供了用于鉴定生长因子的persephin-neurturin-GDNF家族的额外成员的方法。

    Persephin and related growth factors
    3.
    发明授权
    Persephin and related growth factors 失效
    Persephin及相关生长因子

    公开(公告)号:US06232449B1

    公开(公告)日:2001-05-15

    申请号:US08981739

    申请日:1998-08-31

    IPC分类号: C07K1448

    摘要: A novel growth factor, persephin, which belongs to the GDNF/neurturin family of growth factors, is disclosed. The mouse and rat amino acid sequences have been identified. Mouse and rat persephin genomic DNA sequences have been cloned and sequenced and the respective cDNA sequences identified. In addition, methods for treating degenerative conditions using persephin, methods for detecting persephin gene alterations and methods for detecting and monitoring patient levels of persephin are provided. Methods for identifying additional members of the persephin-neurturin-GDNF family of growth factors are also provided.

    摘要翻译: 公开了属于GDNF / neurturin生长因子家族的新生长因子persephin。 已经鉴定了小鼠和大鼠的氨基酸序列。 已经克隆并测序了小鼠和大鼠persephin基因组DNA序列,并鉴定了各自的cDNA序列。 此外,还提供了使用persephin治疗退行性病症的方法,用于检测persephin基因改变的方法以及用于检测和监测患者血浆含量的方法。 还提供了用于鉴定生长因子的persephin-neurturin-GDNF家族的额外成员的方法。

    Method of cell culture using neurturin
    5.
    发明授权
    Method of cell culture using neurturin 失效
    使用neurturin细胞培养的方法

    公开(公告)号:US06743628B1

    公开(公告)日:2004-06-01

    申请号:US09219952

    申请日:1998-12-23

    IPC分类号: C12N502

    摘要: A novel growth factor, neurturin, is disclosed. The human and mouse amino acid sequences have been identified. Human and mouse neurturin genomic DNA sequences have been cloned and sequences and the respective CDNA sequences identified. The subcloning into vectors and the preparation of cells stably transformed with the vectors is also disclosed. In addition, methods for treating degenerative conditions using neurturin, methods for detecting gene alterations and methods for detecting and monitoring patient levels of neurturin are provided. Methods for identifying additional members of the neurturin-GDNF family of growth factors are also provided.

    摘要翻译: 公开了一种新的生长因子neurturin。 人和小鼠的氨基酸序列已被鉴定。 已经克隆了人和小鼠neurturin基因组DNA序列,并鉴定了序列和相应的CDNA序列。 还公开了亚克隆到载体中以及用载体稳定转化的细胞的制备。 另外,提供了使用neurturin治疗退行性病症的方法,用于检测基因改变的方法以及用于检测和监测neurturin患者水平的方法。 还提供了用于鉴定生长因子的neurturin-GDNF家族的其他成员的方法。

    Methods using persephin and related growth factors
    6.
    发明授权
    Methods using persephin and related growth factors 有权
    使用persephin和相关生长因子的方法

    公开(公告)号:US06645937B1

    公开(公告)日:2003-11-11

    申请号:US09220616

    申请日:1998-12-24

    IPC分类号: A61K3818

    摘要: A novel growth factor, persephin, which belongs to the GDNF/neurturin family of growth factors, is disclosed. The mouse and rat amino acid sequences have been identified. Mouse and rat persephin genomic DNA sequences have been cloned and sequenced and the respective cDNA sequences identified. In addition, methods for treating degenerative conditions using persephin, methods for detecting persephin gene alterations and methods for detecting and monitoring patient levels of persephin are provided. Methods for identifying additional members of the persephin-neurturin-GDNF family of growth factors are also provided.

    摘要翻译: 公开了属于GDNF / neurturin生长因子家族的新生长因子persephin。 已经鉴定了小鼠和大鼠的氨基酸序列。 已经克隆并测序了小鼠和大鼠persephin基因组DNA序列,并鉴定了各自的cDNA序列。 此外,还提供了使用persephin治疗退行性病症的方法,用于检测persephin基因改变的方法以及用于检测和监测患者血浆含量的方法。 还提供了用于鉴定生长因子的persephin-neurturin-GDNF家族的额外成员的方法。