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    2, 4-pyrimidine derivatives and use thereof
    2.
    发明授权
    2, 4-pyrimidine derivatives and use thereof 有权
    2,4-嘧啶衍生物及其用途

    公开(公告)号：US09573907B2

    公开(公告)日：2017-02-21

    申请号：US13505651

    申请日：2010-11-02

    申请人： Sunghoon Kim ,  Jung Min Han ,  Hyeong Rae Kim ,  Dong Ju Jeon ,  Jong Hwan Song ,  Kyung Eun Park

    发明人： Sunghoon Kim ,  Jung Min Han ,  Hyeong Rae Kim ,  Dong Ju Jeon ,  Jong Hwan Song ,  Kyung Eun Park

    IPC分类号： A61K31/506 ,  A61K31/5377 ,  C07D409/12 ,  C07D239/60 ,  C07D413/12 ,  C07D239/52 ,  C07D401/12

    CPC分类号： C07D239/60 ,  C07D239/52 ,  C07D401/12

    摘要： The present invention relates to novel 2,4-pyrimidine derivatives and a use thereof, and more particularly, to pyrimidine derivatives which are effective for systemic lupus erythematosus, a composition for preventing and treating systemic lupus erythematosus comprising the same as an active ingredient and a method for screening the same. The present inventors found novel materials inhibiting surface translocation of gp96 by mimicking a function of AIMP1 which is a molecular anchor for an intracellular residence of gp96, and identified in vitro and in vivo activity of the materials for preventing and treating SLE by alleviating SLE plasma in autoimmune diseases. Therefore, the present invention provides a novel method for screening a therapeutic agent for SLE, and preventing or treating SLE using the mechanism.

    摘要翻译： 本发明涉及新的2,4-嘧啶衍生物及其用途，更具体地涉及对系统性红斑狼疮有效的嘧啶衍生物，用于预防和治疗包含其作为活性成分的系统性红斑狼疮的组合物和 筛选方法 本发明人通过模拟作为gp96细胞内宿主的分子锚的AIMP1的功能，发现抑制gp96的表面易位的新型材料，并通过减轻SLE等离子体来预防和治疗SLE的材料的体外和体内活性 自身免疫性疾病 因此，本发明提供了用于筛选SLE治疗剂以及使用该机制预防或治疗SLE的新方法。

    NOVEL 2, 4-PYRIMIDINE DERIVATIVES AND USE THEREOF
    3.
    发明申请
    NOVEL 2, 4-PYRIMIDINE DERIVATIVES AND USE THEREOF 有权
    新二氢吡啶衍生物及其用途

    公开(公告)号：US20120322802A1

    公开(公告)日：2012-12-20

    申请号：US13505651

    申请日：2010-11-02

    申请人： Sunghoon Kim ,  Jung Min Han ,  Hyeong Rae Kim ,  Dong Ju Jeon ,  Jong Hwan Song ,  Kyung Eun Park

    发明人： Sunghoon Kim ,  Jung Min Han ,  Hyeong Rae Kim ,  Dong Ju Jeon ,  Jong Hwan Song ,  Kyung Eun Park

    IPC分类号： A61K31/505 ,  C07D401/12 ,  A61K31/506 ,  C40B30/04 ,  A61K31/5377 ,  A61P29/00 ,  C07D409/12 ,  C07D239/60 ,  C07D413/12

    CPC分类号： C07D239/60 ,  C07D239/52 ,  C07D401/12

    摘要： The present invention relates to novel 2,4-pyrimidine derivatives and a use thereof, and more particularly, to pyrimidine derivatives which are effective for systemic lupus erythematosus, a composition for preventing and treating systemic lupus erythematosus comprising the same as an active ingredient and a method for screening the same. The present inventors found novel materials inhibiting surface translocation of gp96 by mimicking a function of AIMP1 which is a molecular anchor for an intracellular residence of gp96, and identified in vitro and in vivo activity of the materials for preventing and treating SLE by alleviating SLE plasma in autoimmune diseases. Therefore, the present invention provides a novel method for screening a therapeutic agent for SLE, and preventing or treating SLE using the mechanism.

    摘要翻译： 本发明涉及新的2,4-嘧啶衍生物及其用途，更具体地涉及对系统性红斑狼疮有效的嘧啶衍生物，用于预防和治疗包含其作为活性成分的系统性红斑狼疮的组合物和 筛选方法 本发明人通过模拟作为gp96细胞内宿主的分子锚的AIMP1的功能，发现抑制gp96的表面易位的新型材料，并通过减轻SLE等离子体来预防和治疗SLE的材料的体外和体内活性 自身免疫性疾病 因此，本发明提供了用于筛选SLE治疗剂以及使用该机制预防或治疗SLE的新方法。