公开(公告)号：US09573907B2

公开(公告)日：2017-02-21

申请号：US13505651

申请日：2010-11-02

申请人： Sunghoon Kim ,  Jung Min Han ,  Hyeong Rae Kim ,  Dong Ju Jeon ,  Jong Hwan Song ,  Kyung Eun Park

发明人： Sunghoon Kim ,  Jung Min Han ,  Hyeong Rae Kim ,  Dong Ju Jeon ,  Jong Hwan Song ,  Kyung Eun Park

IPC分类号： A61K31/506 ,  A61K31/5377 ,  C07D409/12 ,  C07D239/60 ,  C07D413/12 ,  C07D239/52 ,  C07D401/12

CPC分类号： C07D239/60 ,  C07D239/52 ,  C07D401/12

摘要： The present invention relates to novel 2,4-pyrimidine derivatives and a use thereof, and more particularly, to pyrimidine derivatives which are effective for systemic lupus erythematosus, a composition for preventing and treating systemic lupus erythematosus comprising the same as an active ingredient and a method for screening the same. The present inventors found novel materials inhibiting surface translocation of gp96 by mimicking a function of AIMP1 which is a molecular anchor for an intracellular residence of gp96, and identified in vitro and in vivo activity of the materials for preventing and treating SLE by alleviating SLE plasma in autoimmune diseases. Therefore, the present invention provides a novel method for screening a therapeutic agent for SLE, and preventing or treating SLE using the mechanism.

摘要翻译： 本发明涉及新的2,4-嘧啶衍生物及其用途，更具体地涉及对系统性红斑狼疮有效的嘧啶衍生物，用于预防和治疗包含其作为活性成分的系统性红斑狼疮的组合物和 筛选方法 本发明人通过模拟作为gp96细胞内宿主的分子锚的AIMP1的功能，发现抑制gp96的表面易位的新型材料，并通过减轻SLE等离子体来预防和治疗SLE的材料的体外和体内活性 自身免疫性疾病 因此，本发明提供了用于筛选SLE治疗剂以及使用该机制预防或治疗SLE的新方法。

公开(公告)号：US20120322802A1

公开(公告)日：2012-12-20

申请号：US13505651

申请日：2010-11-02

申请人： Sunghoon Kim ,  Jung Min Han ,  Hyeong Rae Kim ,  Dong Ju Jeon ,  Jong Hwan Song ,  Kyung Eun Park

发明人： Sunghoon Kim ,  Jung Min Han ,  Hyeong Rae Kim ,  Dong Ju Jeon ,  Jong Hwan Song ,  Kyung Eun Park

IPC分类号： A61K31/505 ,  C07D401/12 ,  A61K31/506 ,  C40B30/04 ,  A61K31/5377 ,  A61P29/00 ,  C07D409/12 ,  C07D239/60 ,  C07D413/12

CPC分类号： C07D239/60 ,  C07D239/52 ,  C07D401/12

摘要： The present invention relates to novel 2,4-pyrimidine derivatives and a use thereof, and more particularly, to pyrimidine derivatives which are effective for systemic lupus erythematosus, a composition for preventing and treating systemic lupus erythematosus comprising the same as an active ingredient and a method for screening the same. The present inventors found novel materials inhibiting surface translocation of gp96 by mimicking a function of AIMP1 which is a molecular anchor for an intracellular residence of gp96, and identified in vitro and in vivo activity of the materials for preventing and treating SLE by alleviating SLE plasma in autoimmune diseases. Therefore, the present invention provides a novel method for screening a therapeutic agent for SLE, and preventing or treating SLE using the mechanism.

摘要翻译： 本发明涉及新的2,4-嘧啶衍生物及其用途，更具体地涉及对系统性红斑狼疮有效的嘧啶衍生物，用于预防和治疗包含其作为活性成分的系统性红斑狼疮的组合物和 筛选方法 本发明人通过模拟作为gp96细胞内宿主的分子锚的AIMP1的功能，发现抑制gp96的表面易位的新型材料，并通过减轻SLE等离子体来预防和治疗SLE的材料的体外和体内活性 自身免疫性疾病 因此，本发明提供了用于筛选SLE治疗剂以及使用该机制预防或治疗SLE的新方法。

公开(公告)号：US08143262B2

公开(公告)日：2012-03-27

申请号：US12531818

申请日：2008-03-07

申请人： Dong Ju Jeon ,  Zaesung No ,  Jong Hwan Song ,  Gehyeong Lee ,  Ikyon Kim ,  Chang Min Park ,  Hyae Gyeong Cheon ,  Young Sik Cho ,  Jin Sook Song ,  Myung Ae Bae ,  Sung-eun Yoo

发明人： Dong Ju Jeon ,  Zaesung No ,  Jong Hwan Song ,  Gehyeong Lee ,  Ikyon Kim ,  Chang Min Park ,  Hyae Gyeong Cheon ,  Young Sik Cho ,  Jin Sook Song ,  Myung Ae Bae ,  Sung-eun Yoo

IPC分类号： A01N43/90 ,  A61K31/519 ,  C07D487/00

CPC分类号： C07D487/04

摘要： The present invention relates to novel {7-(3′,4′-dialkoxyphenyl)-[1,2,4]-triazolo[1,5-a]pyrimidine compounds or pharmaceutically acceptable salts thereof, a process for preparing the same, and pharmaceutical compositions for treating or preventing inflammatory diseases including asthma and chronic obstructive pulmonary disease, arthritis, atopic dermatitis, cancers including leukemia, and degenerative brain diseases including Alzheimer's disease, depression and memory impairment, which comprises the same as an active ingredient.

摘要翻译： 本发明涉及新的{7-（3'，4'-二烷氧基苯基） - [1,2,4] - 三唑并[1,5-a]嘧啶化合物或其药学上可接受的盐，其制备方法， 以及用于治疗或预防包括哮喘和慢性阻塞性肺病，关节炎，特应性皮炎，包括白血病，包括阿尔茨海默氏病，抑郁症和记忆障碍在内的退行性脑疾病的炎症性疾病的药物组合物，其包含与活性成分相同的药物组合物。

公开(公告)号：US20100105704A1

公开(公告)日：2010-04-29

申请号：US12531818

申请日：2008-03-07

申请人： Dong Ju Jeon ,  Zaesung No ,  Jong Hwan Song ,  Gehyeong Lee ,  Ikyon Kim ,  Chang Min Park ,  Hyae Gyeong Cheon ,  Young Sik Cho ,  Jin Sook Song ,  Myung Ae Bae ,  Sung-eun Yoo

发明人： Dong Ju Jeon ,  Zaesung No ,  Jong Hwan Song ,  Gehyeong Lee ,  Ikyon Kim ,  Chang Min Park ,  Hyae Gyeong Cheon ,  Young Sik Cho ,  Jin Sook Song ,  Myung Ae Bae ,  Sung-eun Yoo

IPC分类号： A61K31/519 ,  C07D487/04 ,  A61P25/00 ,  A61P11/00

CPC分类号： C07D487/04

摘要： The present invention relates to novel {7-(3′,4′-dialkoxyphenyl)-[1,2,4]-triazolo[1,5-a]pyrimidine compounds or pharmaceutically acceptable salts thereof, a process for preparing the same, and pharmaceutical compositions for treating or preventing inflammatory diseases including asthma and chronic obstructive pulmonary disease, arthritis, atopic dermatitis, cancers including leukemia, and degenerative brain diseases including Alzheimer's disease, depression and memory impairment, which comprises the same as an active ingredient.

摘要翻译： 本发明涉及新的{7-（3'，4'-二烷氧基苯基） - [1,2,4] - 三唑并[1,5-a]嘧啶化合物或其药学上可接受的盐，其制备方法， 以及用于治疗或预防包括哮喘和慢性阻塞性肺病，关节炎，特应性皮炎，包括白血病，包括阿尔茨海默氏病，抑郁症和记忆障碍在内的退行性脑疾病的炎症性疾病的药物组合物，其包含与活性成分相同的药物组合物。

公开(公告)号：US06239076B1

公开(公告)日：2001-05-29

申请号：US09647902

申请日：2000-10-06

申请人： Eung Kul Ryu ,  Dong Ju Jeon ,  Jong Hwan Song ,  Hyoung Rae Kim ,  Jung No Lee ,  Kyoung Mahn Kim ,  Kwang Yun Cho

发明人： Eung Kul Ryu ,  Dong Ju Jeon ,  Jong Hwan Song ,  Hyoung Rae Kim ,  Jung No Lee ,  Kyoung Mahn Kim ,  Kwang Yun Cho

IPC分类号： A61K3142

CPC分类号： C07D413/12 ,  A01N43/80

摘要： The present invention relates to 2-(5-isoxazolinylmethyloxyphenyl)-4,5,6,7-tetrahydro-2H-indazole derivatives of formula 1, their preparation method and their use as herbicides. As the compounds have excellent herbicidal activity against paddy weeds comprising ECHOR, SCPJU, MOOVA, CYPSE and SAGPY, and better selectivity, the compounds of the present invention are typically useful as herbicides for control of paddy weeds in conditions with seeded rice and transferred rice.

摘要翻译： 本发明涉及式1的2-（5-异恶唑啉基甲氧基苯基）-4,5,6,7-四氢-2H-吲唑衍生物及其制备方法及其作为除草剂的用途。 由于该化合物对包括ECHOR，SCPJU，MOOVA，CYPSE和SAGPY的稻田杂草具有优异的除草活性，并且具有更好的选择性，本发明的化合物通常可用作用于在播种稻和转移稻的条件下控制稻田杂草的除草剂。