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6 条记录 (耗时 0.052 秒)

    Organic Compounds
    5.
    发明申请
    Organic Compounds 审中-公开

    公开(公告)号：US20090270417A1

    公开(公告)日：2009-10-29

    申请号：US12304389

    申请日：2007-06-11

    申请人： Juergen Klaus Maibaum ,  Edwige Liliane Jeanne Lorthiois ,  Peter Buehimayer

    发明人： Juergen Klaus Maibaum ,  Edwige Liliane Jeanne Lorthiois ,  Peter Buehimayer

    IPC分类号： A61K31/40 ,  C07D207/09 ,  C07D405/12 ,  C07D403/12 ,  A61K31/4025 ,  A61K31/497 ,  A61P9/12

    CPC分类号： C07D405/12 ,  C07D207/09 ,  C07D403/12

    摘要： Novel 3,4-di-, 3,3,4-di-, 3,4,4,-tri- and 3,3,4,4-tetra-substituted pyrrolidine compounds, these compounds for use in the diagnostic and therapeutic treatment of a warm-blooded animal, especially for the treatment of a disease (=disorder) that depends on inappropriate activity of renin; the use of a compound of that class for the preparation of a pharmaceutical formulation for the treatment of a disease that depends on inappropriate activity of renin; the use of a compound of that class in the treatment of a disease that depends on inappropriate activity of renin; pharmaceutical formulations comprising a said substituted pyrrolidine compound, and/or a method of treatment comprising administering a said substituted pyrrolidine compound, a method for the manufacture of said substituted pyrrolidine compounds, and novel intermediates and partial steps for their synthesis are described. The substituted pyrrolidine compounds are especially of the formula (I) wherein the substituents are as described in the specification.

    Organic Compounds
    6.
    发明申请
    Organic Compounds 审中-公开
    有机化合物

    公开(公告)号：US20090281161A1

    公开(公告)日：2009-11-12

    申请号：US12304425

    申请日：2007-06-11

    申请人： Juergen Klaus Maibaum ,  Edwige Liliane Jeanne Lorthiois

    发明人： Juergen Klaus Maibaum ,  Edwige Liliane Jeanne Lorthiois

    IPC分类号： A61K31/4025 ,  A61K31/40 ,  C07D207/14 ,  C07D405/12

    CPC分类号： C07D405/12 ,  C07D207/14

    摘要： Novel 3,4-di-, 3,3,4-di-, 3,4,4,-tri- and 3,3,4,4-tetra-substituted pyrrolidine compounds, these compounds for use in the diagnostic and therapeutic treatment of a warm-blooded animal, especially for the treatment of a disease (=disorder) that depends on inappropriate activity of renin; the use of a compound of that class for the preparation of a pharmaceutical formulation for the treatment of a disease that depends on inappropriate activity of renin; the use of a compound of that class in the treatment of a disease that depends on inappropriate activity of renin; pharmaceutical formulations comprising a said substituted pyrrolidine compound, and/or a method of treatment comprising administering a said substituted pyrrolidine compound, a method for the manufacture of said substituted pyrrolidine compounds, and novel intermediates and partial steps for their synthesis are described. The substituted pyrrolidine compounds are especially of the formula (I) wherein the substituents are as described in the specification.

    摘要翻译： 新型3,4-二，3,3,4-二，3,4,4， - 和 - 3,3,4,4-四取代的吡咯烷化合物，用于诊断和治疗 治疗温血动物，特别是治疗依赖于肾素不适当活动的疾病（=病症）; 使用该类化合物制备用于治疗依赖于肾素不适当活性的疾病的药物制剂; 使用该类化合物治疗依赖肾素不适当活动的疾病; 包括所述取代的吡咯烷化合物的药物制剂和/或包括施用所述取代的吡咯烷化合物的方法，制备所述取代的吡咯烷化合物的方法和新的中间体及其合成的部分步骤。 取代的吡咯烷化合物特别是式（I），其中取代基如说明书中所述。