利索-全球专利检索

  1. 登录
  2. 注册

搜索结果

40 条记录 (耗时 0.026 秒)

    Process for the preparation of suspensions of drug particles for inhalation delivery
    1.
    发明授权
    Process for the preparation of suspensions of drug particles for inhalation delivery 有权
    用于制备用于吸入输送的药物颗粒的悬浮液的方法

    公开(公告)号：US06464958B1

    公开(公告)日：2002-10-15

    申请号：US09830884

    申请日：2001-05-22

    申请人： Eva Bernini ,  Chiara Malvolti ,  Raffaella Garzia ,  Gaetano Brambilla ,  Paolo Chiesi

    发明人： Eva Bernini ,  Chiara Malvolti ,  Raffaella Garzia ,  Gaetano Brambilla ,  Paolo Chiesi

    IPC分类号： A61K912

    CPC分类号： A61K9/0078 ,  A61K31/573 ,  Y10S977/904 ,  Y10S977/906 ,  Y10S977/926

    摘要： The invention is directed to a process for the preparation of suspensions of drug particles for inhalation delivery, said process providing particles of optimized particle size and distribution homogeneously dispersed in the carrier. The process, which is also suitable for the preparation of sterile suspensions, includes the step of homogenizing and micronizing the formulation in a turboemulsifier provided with a high-potency turbine, optionally followed by a treatment in a high-pressure homogenizer. A further aspect of the invention is directed to a process for preparing micronized sterile beclomethasone dipropionate by gamma-irradiation.

    摘要翻译： 本发明涉及用于制备用于吸入输送的药物颗粒的悬浮液的方法，所述方法提供均匀分散在载体中的优化粒径和分布的颗粒。 也适用于制备无菌悬浮液的方法包括在具有高效率涡轮机的涡轮乳化器中均化和微粉化制剂的步骤，任选地随后在高压均化器中进行处理。 本发明的另一方面涉及通过γ-照射制备微粉化无色倍氯米松二丙酸酯的方法。

    Pharmaceutical aerosol composition containing HFA 227 and HFA 134a
    3.
    发明授权
    Pharmaceutical aerosol composition containing HFA 227 and HFA 134a 失效
    含有HFA 227和HFA 134a的药物气溶胶组合物

    公开(公告)号：US06713047B1

    公开(公告)日：2004-03-30

    申请号：US09831886

    申请日：2001-07-18

    申请人： David Lewis ,  David Ganderton ,  Brian Meakin ,  Paolo Ventura ,  Gaetano Brambilla ,  Raffaella Garzia

    发明人： David Lewis ,  David Ganderton ,  Brian Meakin ,  Paolo Ventura ,  Gaetano Brambilla ,  Raffaella Garzia

    IPC分类号： A61K912

    CPC分类号： A61K9/008

    摘要： In a solution composition for use in an aerosol inhaler which comprises an active material, a propellant containing a hydrofluoroalkane, a cosolvent and optionally a low volatility compound the use of a mixture of HFA 134a and HFA 227 allows to modulate the mass median aerodynamic diameter (MMAD) of the aerosol particles on actuation of the inhaler to target specific regions of the respiratory tract. Moreover the fine particle dose (FPD) of the active ingredient in the composition increases by reducing the metering chamber volume.

    摘要翻译： 在用于气溶胶吸入器的溶液组合物中，其包含活性物质，含有氢氟烷烃，助溶剂和任选的低挥发性化合物的推进剂，使用HFA134a和HFA227的混合物允许调节质量中值空气动力学直径（ MMAD）气雾剂颗粒在致动吸入器以靶向呼吸道的特定区域时。 此外，组合物中活性成分的细颗粒剂量（FPD）通过减少计量室体积而增加。