公开(公告)号：US11433064B2

公开(公告)日：2022-09-06

申请号：US16919562

申请日：2020-07-02

Applicant: Exelixis, Inc.

Inventor： Dana T. Aftab ,  Thomas Mueller ,  Aaron Weitzman ,  Jaymes Holland

IPC: A61K51/00 ,  A61M36/14 ,  A61K31/47 ,  A61K31/4706 ,  A61K41/00 ,  A61K45/06 ,  A61K31/495 ,  A61K31/4188 ,  A61N5/10 ,  A61K31/015 ,  A61P43/00 ,  A61K31/517 ,  A61P35/00 ,  C07D215/22

Abstract: Methods of treating cancer by administering a compound of Formula I, or a pharmaceutically acceptable salt or solvate thereof, in combination with other cancer treatments are described, wherein R1 is halo; R2 is halo; and Q is CH or N.

公开(公告)号：US20200330451A1

公开(公告)日：2020-10-22

申请号：US16919562

申请日：2020-07-02

Applicant: Exelixis, Inc.

Inventor： Dana T. Aftab ,  Thomas Mueller ,  Aaron Weitzman ,  Jaymes Holland

IPC: A61K31/47 ,  A61K31/4706 ,  A61K41/00 ,  A61K45/06 ,  A61K31/495 ,  A61K31/4188 ,  A61N5/10

Abstract: Methods of treating cancer by administering a compound of Formula I, or a pharmaceutically acceptable salt or solvate thereof, in combination with other cancer treatments are described, wherein R1 is halo; R2 is halo; and Q is CH or N.

公开(公告)号：US20190151302A1

公开(公告)日：2019-05-23

申请号：US16251617

申请日：2019-01-18

Applicant: Exelixis, Inc.

Inventor： Dana T. Aftab ,  Thomas Mueller ,  Aaron Weitzman ,  Jaymes Holland

IPC: A61K31/47 ,  A61N5/10 ,  A61K31/4188 ,  A61K31/4706 ,  A61K45/06 ,  A61K41/00 ,  A61K31/495

Abstract: Methods of treating cancer by administering a compound of Formula I, or a pharmaceutically acceptable salt or solvate thereof, in combination with other cancer treatments are described, wherein R1 is halo; R2 is halo; and Q is CH or N.

公开(公告)号：US20140330170A1

公开(公告)日：2014-11-06

申请号：US14356938

申请日：2012-11-08

Applicant: Exelixis, Inc.

Inventor： Jaymes Holland

IPC: A61B6/00

CPC classification number: A61B6/505 ,  A61B6/032 ,  A61B6/037 ,  A61B6/508 ,  A61B6/5217 ,  A61K31/47

Abstract: This invention is directed to a method for quantifying cancer treatment response in patients with bone metastases using computer aided bone scan assessment, comprising: (a) obtaining a bone scan image; (b) normalizing the obtained bone scan image to identify normalized bone scan lesions; and (c) quantitatively assessing the normalized bone scan lesions using bone scan lesion area, bone scan intensity, or bone scan lesion count.

Abstract translation: 本发明涉及一种使用计算机辅助骨扫描评估来量化骨转移患者的癌症治疗反应的方法，包括：（a）获得骨扫描图像; （b）归一化所获得的骨扫描图像以识别标准化的骨扫描病变; 和（c）使用骨扫描病变面积，骨扫描强度或骨扫描病灶计数定量评估标准化骨扫描病变。

公开(公告)号：US20230181559A1

公开(公告)日：2023-06-15

申请号：US17873918

申请日：2022-07-26

Applicant: Exelixis, Inc.

Inventor： Dana T. Aftab ,  Thomas Mueller ,  Aaron Weitzman ,  Jaymes Holland

IPC: A61K31/47 ,  A61K31/4706 ,  A61K41/00 ,  A61K45/06 ,  A61K31/495 ,  A61K31/4188 ,  A61N5/10

CPC classification number: A61K31/47 ,  A61K31/4706 ,  A61K41/00 ,  A61K45/06 ,  A61K31/495 ,  A61K31/4188 ,  A61N5/10 ,  A61K31/015

Abstract: Methods of treating cancer by administering a compound of Formula I,




or a pharmaceutically acceptable salt or solvate thereof, in combination with other cancer treatments are described, wherein R1 is halo; R2 is halo; and Q is CH or N.

公开(公告)号：US10736886B2

公开(公告)日：2020-08-11

申请号：US16251617

申请日：2019-01-18

Applicant: Exelixis, Inc.

Inventor： Dana T. Aftab ,  Thomas Mueller ,  Aaron Weitzman ,  Jaymes Holland

IPC: A61K51/00 ,  A61M36/14 ,  A61K31/47 ,  A61K31/4706 ,  A61K41/00 ,  A61K45/06 ,  A61K31/495 ,  A61K31/4188 ,  A61N5/10 ,  A61K31/015

Abstract: Methods of treating cancer by administering a compound of Formula I, or a pharmaceutically acceptable salt or solvate thereof, in combination with other cancer treatments are described, wherein R1 is halo; R2 is halo; and Q is CH or N.

公开(公告)号：US20160000772A1

公开(公告)日：2016-01-07

申请号：US14699683

申请日：2015-04-29

Applicant: Exelixis, Inc.

Inventor： Dana T. Aftab ,  Thomas Mueller ,  Aaron Weitzman ,  Jaymes Holland

IPC: A61K31/47 ,  A61N5/10 ,  A61K31/4188

CPC classification number: A61K31/47 ,  A61K31/4188 ,  A61K31/4706 ,  A61K31/495 ,  A61K41/00 ,  A61K45/06 ,  A61N5/10 ,  A61K2300/00

Abstract: Methods of treating cancer by administering a compound of Formula I, or a pharmaceutically acceptable salt or solvate thereof, in combination with other cancer treatments are described, wherein R1 is halo; R2 is halo; and Q is CH or N.

Abstract translation: 描述了通过与其它癌症治疗组合施用式I化合物或其药学上可接受的盐或溶剂合物来治疗癌症的方法，其中R1是卤素; R2是卤素; Q为CH或N.