公开(公告)号：US11597699B2

公开(公告)日：2023-03-07

申请号：US16853043

申请日：2020-04-20

申请人： Exelixis, Inc.

发明人： Naing Aay ,  Neel Kumar Anand ,  Charles M. Blazey ,  Owen Joseph Bowles ,  Joerg Bussenius ,  Simona Costanzo ,  Jeffry Kimo Curtis ,  Steven Charles DeFina ,  Larisa Dubenko ,  Anagha Abhijit Joshi ,  Abigail R. Kennedy ,  Angie Inyoung Kim ,  Elena S. Koltun ,  Jean-Claire Limun Manalo ,  Csaba J. Peto ,  Kenneth D. Rice ,  Tsze H. Tsang

IPC分类号： C07D205/04 ,  C07D205/06 ,  C07D401/06 ,  C07D401/12 ,  C07D401/14 ,  C07D403/04 ,  C07D403/06 ,  C07D403/12 ,  C07D405/12 ,  C07D409/06 ,  C07D413/12 ,  C07D413/14 ,  C07D417/12 ,  C07D471/04 ,  C07D401/04 ,  C07D409/12

摘要： Disclosed are compounds of Formula (I) and pharmaceutically acceptable salts and solvates thereof. Such compounds are MEK inhibitors and are useful in the treatment of proliferative diseases, such as cancer. Also disclosed are pharmaceutical compositions containing such compounds as well as methods of using the compounds and compositions of the invention in the treatment of cancer.

公开(公告)号：US20170166523A9

公开(公告)日：2017-06-15

申请号：US14615079

申请日：2015-02-05

申请人： Exelixis, Inc.

发明人： Naing Aay ,  Neel Kumar Anand ,  Charles M. Blazey ,  Owen Joseph Bowles ,  Joerg Bussenius ,  Simona Costanzo ,  Jeffry Kimo Curtis ,  Steven Charles DeFina ,  Larisa Dubenko ,  Anagha Abhijit Joshi ,  Abigail R. Kennedy ,  Angie Inyoung Kim ,  Elena S. Koltun ,  Jean-Claire Limun Manalo ,  Csaba J. Peto ,  Kenneth D. Rice ,  Tsze H. Tsang

IPC分类号： C07D205/04 ,  C07D403/06 ,  C07D401/14 ,  C07D471/04 ,  C07D401/04 ,  C07D403/04 ,  C07D409/06

CPC分类号： C07D205/04 ,  C07D205/06 ,  C07D401/04 ,  C07D401/06 ,  C07D401/12 ,  C07D401/14 ,  C07D403/04 ,  C07D403/06 ,  C07D403/12 ,  C07D405/12 ,  C07D409/06 ,  C07D409/12 ,  C07D413/12 ,  C07D413/14 ,  C07D417/12 ,  C07D471/04

摘要： Disclosed are compounds of Formula I: and pharmaceutically acceptable salts and solvates thereof. Such compounds are MEK inhibitors and are useful in the treatment of proliferative diseases, such as cancer. Also disclosed are pharmaceutical compositions containing such compounds as well as methods of using the compounds and compositions of the invention in the treatment of cancer.

公开(公告)号：US20200283383A1

公开(公告)日：2020-09-10

申请号：US16853043

申请日：2020-04-20

申请人： Exelixis, Inc.

发明人： Naing Aay ,  Neel Kumar Anand ,  Charles M. Blazey ,  Owen Joseph Bowles ,  Joerg Bussenius ,  Simona Costanzo ,  Jeffry Kimo Curtis ,  Steven Charles DeFina ,  Larisa Dubenko ,  Anagha Abhijit Joshi ,  Abigail R. Kennedy ,  Angie Inyoung Kim ,  Elena S. Koltun ,  Jean-Claire Limun Manalo ,  Csaba J. Peto ,  Kenneth D. Rice ,  Tsze H. Tsang

IPC分类号： C07D205/04 ,  C07D205/06 ,  C07D401/06 ,  C07D401/12 ,  C07D401/14 ,  C07D403/04 ,  C07D403/06 ,  C07D403/12 ,  C07D405/12 ,  C07D409/06 ,  C07D409/12 ,  C07D413/12 ,  C07D413/14 ,  C07D417/12 ,  C07D471/04 ,  C07D401/04

摘要： Disclosed are compounds of Formula (I) and pharmaceutically acceptable salts and solvates thereof. Such compounds are MEK inhibitors and are useful in the treatment of proliferative diseases, such as cancer. Also disclosed are pharmaceutical compositions containing such compounds as well as methods of using the compounds and compositions of the invention in the treatment of cancer.

公开(公告)号：US20190144382A1

公开(公告)日：2019-05-16

申请号：US15952923

申请日：2018-04-13

申请人： Exelixis, Inc.

发明人： Naing Aay ,  Neel Kumar Anand ,  Charles M. Blazey ,  Owen Joseph Bowles ,  Joerg Bussenius ,  Simona Costanzo ,  Jeffry Kimo Curtis ,  Steven Charles DeFina ,  Larisa Dubenko ,  Anagha Abhijit Joshi ,  Abigail R. Kennedy ,  Angie Inyoung Kim ,  Elena S. Koltun ,  Jean-Claire Limun Manalo ,  Csaba J. Peto ,  Kenneth D. Rice ,  Tsza H. Tsang

IPC分类号： C07D205/04 ,  C07D401/04 ,  C07D471/04 ,  C07D413/14 ,  C07D413/12 ,  C07D409/12 ,  C07D409/06 ,  C07D405/12 ,  C07D403/12 ,  C07D403/06 ,  C07D403/04 ,  C07D401/14 ,  C07D401/12 ,  C07D401/06 ,  C07D205/06 ,  C07D417/12

摘要： Disclosed are compounds of Formula (I) and pharmaceutically acceptable salts and solvates thereof. Such compounds are MEK inhibitors and are useful in the treatment of proliferative diseases, such as cancer. Also disclosed are pharmaceutical compositions containing such compounds as well as methods of using the compounds and compositions of the invention in the treatment of cancer.

公开(公告)号：US20140275527A1

公开(公告)日：2014-09-18

申请号：US13929062

申请日：2013-06-27

申请人： Exelixis, Inc.

发明人： Naing Aay ,  Neel Kumar Anand ,  Charles M. Blazey ,  Owen Joseph Bowles ,  Joerg Bussenius ,  Simona Costanzo ,  Jeffry Kimo Curtis ,  Steven Charles DeFina ,  Larisa Dubenko ,  Anagha Abhijit Joshi ,  Abigail R. Kennedy ,  Angie Inyoung Kim ,  Elena S. Koltun ,  Jean-Claire Limun Manalo ,  Csaba J. Peto ,  Kenneth D. Rice ,  Tsze H. Tsang

IPC分类号： C07D471/04 ,  C07D409/06 ,  C07D403/04 ,  C07D401/04 ,  C07D205/04 ,  C07D205/06

CPC分类号： C07D205/04 ,  C07D205/06 ,  C07D401/04 ,  C07D401/06 ,  C07D401/12 ,  C07D401/14 ,  C07D403/04 ,  C07D403/06 ,  C07D403/12 ,  C07D405/12 ,  C07D409/06 ,  C07D409/12 ,  C07D413/12 ,  C07D413/14 ,  C07D417/12 ,  C07D471/04

摘要： Disclosed are compounds of Formula (I) and pharmaceutically acceptable salts and solvates thereof. Such compounds are MEK inhibitors and are useful in the treatment of proliferative diseases, such as cancer. Also disclosed are pharmaceutical compositions containing such compounds as well as methods of using the compounds and compositions of the invention in the treatment of cancer.

摘要翻译： 公开了式（I）的化合物及其药学上可接受的盐和溶剂化物。 这些化合物是MEK抑制剂，可用于治疗增殖性疾病如癌症。 还公开了含有这些化合物的药物组合物以及使用本发明化合物和组合物治疗癌症的方法。

公开(公告)号：US20200031770A1

公开(公告)日：2020-01-30

申请号：US16597607

申请日：2019-10-09

申请人： Exelixis, Inc.

发明人： Naing Aay ,  Neel Kumar Anand ,  Charles M. Blazey ,  Owen Joseph Bowles ,  Joerg Bussenlus ,  Simona Costanzo ,  Jeffry Kimo Curtis ,  Steven Charles DeFina ,  Larisa Dubenko ,  Anagha Abhijit Joshi ,  Abigall R. Kennedy ,  Angle Inyoung Kim ,  Elena S. Koltun ,  Jean-Claire Limun Manalo ,  Csaba J. Peto ,  Kenneth D. Rice ,  Tsze H. Tsang

IPC分类号： C07D205/04 ,  C07D205/06 ,  C07D401/06 ,  C07D401/12 ,  C07D401/14 ,  C07D403/04 ,  C07D403/06 ,  C07D403/12 ,  C07D405/12 ,  C07D409/06 ,  C07D409/12 ,  C07D413/12 ,  C07D413/14 ,  C07D417/12 ,  C07D471/04 ,  C07D401/04

摘要： Disclosed are compounds of Formula (I) and pharmaceutically acceptable salts and solvates thereof. Such compounds are MEK inhibitors and are useful in the treatment of proliferative diseases, such as cancer. Also disclosed are pharmaceutical compositions containing such compounds as well as methods of using the compounds and compositions of the invention in the treatment of cancer.

公开(公告)号：US20150141399A1

公开(公告)日：2015-05-21

申请号：US14615079

申请日：2015-02-05

申请人： Exelixis, Inc.

发明人： Naing Aay ,  Neel Kumar Anand ,  Charles M. Blazey ,  Owen Joseph Bowles ,  Joerg Bussenius ,  Simona Costanzo ,  Jeffry Kimo Curtis ,  Steven Charles DeFina ,  Larisa Dubenko ,  Anagha Abhijit Joshi ,  Abigail R. Kennedy ,  Angie Inyoung Kim ,  Elena S. Koltun ,  Jean-Claire Limun Manalo ,  Csaba J. Peto ,  Kenneth D. Rice ,  Tsze H. Tsang

IPC分类号： C07D205/04 ,  C07D403/06 ,  C07D401/14 ,  C07D471/04 ,  C07D401/04 ,  C07D403/04 ,  C07D409/06

CPC分类号： C07D205/04 ,  C07D205/06 ,  C07D401/04 ,  C07D401/06 ,  C07D401/12 ,  C07D401/14 ,  C07D403/04 ,  C07D403/06 ,  C07D403/12 ,  C07D405/12 ,  C07D409/06 ,  C07D409/12 ,  C07D413/12 ,  C07D413/14 ,  C07D417/12 ,  C07D471/04

摘要： Disclosed are compounds of Formula I: and pharmaceutically acceptable salts and solvates thereof. Such compounds are MEK inhibitors and are useful in the treatment of proliferative diseases, such as cancer. Also disclosed are pharmaceutical compositions containing such compounds as well as methods of using the compounds and compositions of the invention in the treatment of cancer.

摘要翻译： 公开了式I的化合物及其药学上可接受的盐和溶剂化物。 这些化合物是MEK抑制剂，可用于治疗增殖性疾病如癌症。 还公开了含有这些化合物的药物组合物以及使用本发明化合物和组合物治疗癌症的方法。