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公开(公告)号:US07270968B2
公开(公告)日:2007-09-18
申请号:US10344744
申请日:2001-08-14
IPC分类号: G01N33/567 , C12Q1/68 , C12N15/63 , C07H21/02 , C07H21/04
CPC分类号: C07K14/723 , C07K14/635 , G01N2333/723 , G01N2500/10 , G01N2510/00
摘要: The invention relates to a mammalian cell lacking type-1 parathyroid hormone (PTH)/parathyroid hormone-related peptide (PTHrP) receptor (PTH1R) activity and containing carboxyl-terminal parathyroid hormone receptor (CPTHR) activity. The invention also relates to a method of screening for agonists or antagonists for CPTHR.
摘要翻译: 本发明涉及缺乏1型甲状旁腺激素(PTH)/甲状旁腺激素相关肽(PTHrP)受体(PTH1R)活性并含有羧基末端甲状旁腺激素受体(CPTHR)活性的哺乳动物细胞。 本发明还涉及筛选CPTHR的激动剂或拮抗剂的方法。