公开(公告)号：US20010034464A1

公开(公告)日：2001-10-25

申请号：US09836682

申请日：2001-04-06

Applicant: FIRMENICH SA

Inventor： Hubert Mimoun

IPC: B01J021/00

CPC classification number: B01J31/2226 ,  B01J31/1805 ,  B01J31/181 ,  B01J31/1815 ,  B01J31/2234 ,  B01J31/2239 ,  B01J31/2243 ,  B01J2231/64 ,  B01J2531/0216 ,  B01J2531/26 ,  C07C29/14 ,  C07C29/143 ,  C07C29/147 ,  C07C403/02 ,  C07C403/08 ,  C07C2601/10 ,  C07C2601/16 ,  C07C2602/28 ,  C07C33/22 ,  C07C33/025 ,  C07C33/14 ,  C07C33/20 ,  C07C33/16 ,  C07C35/36 ,  C07C33/02 ,  C07C33/12 ,  C07C35/08 ,  C07C31/125

Abstract: A reductive system including a silane, preferably PMHS, and an active zinc compound, which is monomeric and not a hydride, wherein a reduction of a carbonyl substrate to a corresponding alcohol is achievable.

Abstract translation: 包括硅烷，优选PMHS和活性锌化合物的还原体系，其为单体且不是氢化物，其中羰基底物还原成相应的醇是可实现的。

公开(公告)号：US20020161252A1

公开(公告)日：2002-10-31

申请号：US10114976

申请日：2002-04-04

Applicant: Firmenich SA, a Swiss company

Inventor： Hubert Mimoun

IPC: C07F003/06

CPC classification number: B01J31/2243 ,  B01J31/1805 ,  B01J31/223 ,  B01J31/2282 ,  B01J2231/64 ,  B01J2531/26 ,  B01J2531/27 ,  B01J2531/845 ,  C07B2200/07 ,  C07C29/14 ,  C07C29/143 ,  C07C29/147 ,  C07C2602/10 ,  C07C33/20 ,  C07C33/18 ,  C07C35/36

Abstract: A process for the enantioselective reduction of prochiral ketones to chiral alcohols by (a) the reaction of a prochiral ketone with a silane agent, which is present in a stoichiometric quantity, in the presence of a catalyst derived from a Zn, Co or Cd precursor compound and from a chiral amine, imine, alcohol or amino alcohol ligand; (b) the hydrolysis of the siloxane obtained using an appropriate agent; and (c) the separation and purification of the optically active alcohol formed. Polymethylhydrosiloxane (PMHS) is a preferred silane agent, zinc is a preferred metal, and the precursor compound is produced by reacting a salt or complex of the respective metal with the reducing agent. In another embodiment, an appropriate salt of the chosen metal is used directly in the reaction with the chiral ligand to produce the catalytic form after reaction with the ligand. The process enables high enantiomeric excesses (ee) to be obtained in chiral alcohols.

Abstract translation: 通过（a）在由Zn，Co或Cd前体衍生的催化剂存在下，以前者手段将酮与硅烷试剂以化学计量的量存在反应，将前手性酮对映选择性地还原成手性醇的方法 化合物和手性胺，亚胺，醇或氨基醇配体; （b）使用适当的试剂水解得到的硅氧烷; 和（c）形成的光学活性醇的分离和纯化。 聚甲基氢硅氧烷（PMHS）是优选的硅烷剂，锌是优选的金属，前体化合物是通过使各种金属的盐或络合物与还原剂反应来制备的。 在另一个实施方案中，所选金属的合适的盐直接用于与手性配体的反应中，以在与配体反应后产生催化形式。 该方法能够在手性醇中获得高对映体过量（ee）。

公开(公告)号：US20030171210A1

公开(公告)日：2003-09-11

申请号：US10345285

申请日：2003-01-16

Applicant: FIRMENICH SA

Inventor： Hubert Mimoun

IPC: B01J031/00

CPC classification number: B01J31/2226 ,  B01J31/1805 ,  B01J31/181 ,  B01J31/1815 ,  B01J31/2234 ,  B01J31/2239 ,  B01J31/2243 ,  B01J2231/64 ,  B01J2531/0216 ,  B01J2531/26 ,  C07C29/14 ,  C07C29/143 ,  C07C29/147 ,  C07C403/02 ,  C07C403/08 ,  C07C2601/10 ,  C07C2601/16 ,  C07C2602/28 ,  C07C33/22 ,  C07C33/025 ,  C07C33/14 ,  C07C33/20 ,  C07C33/16 ,  C07C35/36 ,  C07C33/02 ,  C07C33/12 ,  C07C35/08 ,  C07C31/125

Abstract: A reductive system including a silane, preferably PMHS, and an active zinc compound, which is monomeric and not a hydride, wherein a reduction of a carbonyl substrate to a corresponding alcohol is achievable.