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公开(公告)号：US20220348657A1
公开(公告)日：2022-11-03
申请号：US17604505
申请日：2020-04-17
发明人： Luis BORGES , Artur KARASYOV , Zheng MENG , Shawn RUSSELL , Nathan SALLEE , Hongbing ZHANG , Aileen ZHOU
IPC分类号： C07K16/28 , C07K14/705 , G01N33/554
摘要： Provided herein are components (e.g., cells and soluble proteins), systems, and methods for assessing the biological activity of soluble proteins comprising an Fc domain and a CD28-binding domain (e.g., CD80 extracellular domain Fc fusion proteins).
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公开(公告)号：US20200255528A1
公开(公告)日：2020-08-13
申请号：US16814627
申请日：2020-03-10
发明人： Charles KAPLAN , Derrick HOUSER , Luis BORGES , Gloria BRATTICH , David BELLOVIN , Felicia KEMP , Majid GHODDUSI , Nels P. NIELSON , Kathy MILLER , Maike SCHMIDT
IPC分类号： C07K16/28 , G01N33/574 , A61P35/00
摘要： The present disclosure provides antibodies and antigen-binding fragments thereof that specifically bind to human B7-H4 (and optionally cynomolgus monkey, mouse, and/or rat B7-H4) and compositions comprising such antibodies or antigen-binding fragments thereof. In a specific aspect, the antibodies or antigen-binding fragments thereof that specifically bind to human B7-H4 increase T cell proliferation, increase interferon-gamma production, and/or deplete B7-H4 expressing cells via ADCC activity. The present disclosure also provides methods for treating disorders, such as cancer, by administering an antibody or antigen-binding fragment thereof that specifically binds to human B7-H4.
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公开(公告)号：US20180147271A1
公开(公告)日：2018-05-31
申请号：US15575220
申请日：2016-05-17
发明人： Richard MORGAN , Robert SIKORSKI , Brian WONG , Emma MASTELLER , Luis BORGES , Cheng LIU , Yiyang XU
IPC分类号： A61K39/00 , C07K14/725 , C07K16/28 , C07K16/30 , A61P35/02
CPC分类号： A61K39/0011 , A61K2039/505 , A61P35/02 , C07K14/7051 , C07K16/2803 , C07K16/30 , C07K2317/622 , C07K2317/73 , C07K2319/03 , C07K2319/74
摘要： The invention provides improved compositions for adoptive cell therapies for cancers that express ROR1.
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