公开(公告)号：US12285331B2

公开(公告)日：2025-04-29

申请号：US16820274

申请日：2020-03-16

Applicant: Foldax, Inc. ,  California Institute of Technology

Inventor： Garrett Johnson ,  Jason G. Beith ,  Marek Lhotak ,  Praveen De Silva ,  Peter Millson ,  Francis P. Maguire ,  Morteza Gharib

IPC: A61F2/24 ,  A61L27/18 ,  C08G18/61

Abstract: Improved prosthetic valves, their methods of manufacture, and systems and devices for manufacturing the valves are described. The prosthetic valves can be configured for transcatheter implantation. The prosthetic valves can have artificial leaflets. The prosthetic valves can be manufactured in numerous ways, such as by polymeric dipping processes and/or electrospinning. Sponge-like polymers for valves and other medical devices are also disclosed.

公开(公告)号：US20210038379A1

公开(公告)日：2021-02-11

申请号：US16820274

申请日：2020-03-16

Applicant: Foldax, Inc. ,  California Institute of Technology

Inventor： Garrett Johnson ,  Jason G. Beith ,  Marek Lhotak ,  Praveen De Silva ,  Peter Millson ,  Francis P. Maguire ,  Morteza Gharib

IPC: A61F2/24 ,  A61L27/18 ,  C08G18/61

Abstract: Improved prosthetic valves, their methods of manufacture, and systems and devices for manufacturing the valves are described. The prosthetic valves can be configured for transcatheter implantation. The prosthetic valves can have artificial leaflets. The prosthetic valves can be manufactured in numerous ways, such as by polymeric dipping processes and/or electrospinning. Sponge-like polymers for valves and other medical devices are also disclosed.

公开(公告)号：US20210228348A1

公开(公告)日：2021-07-29

申请号：US17231892

申请日：2021-04-15

Applicant: Foldax, Inc. ,  California Institute of Technology

Inventor： Jason G. Beith ,  Morteza Gharib ,  Stephanie Rider ,  Manuel Bedrossian

IPC: A61F2/24

Abstract: Improved prosthetic heart valves, their methods of manufacture, and systems and devices for manufacturing the valves are described. The prosthetic heart valves can be configured for transcatheter implantation. The prosthetic heart valves can have artificial leaflets. The prosthetic heart valves can be manufactured in numerous ways, such as by polymeric dipping processes.

公开(公告)号：US11000369B2

公开(公告)日：2021-05-11

申请号：US16215376

申请日：2018-12-10

Applicant: FOLDAX, INC. ,  CALIFORNIA INSTITUTE OF TECHNOLOGY

Inventor： Morteza Gharib ,  Manuel Bedrossian ,  Stephanie Rider ,  Jason G. Beith

IPC: A61F2/24

Abstract: Improved prosthetic heart valves, their methods of manufacture, and systems and devices for manufacturing the valves are described. The prosthetic heart valves can be configured for transcatheter implantation. The prosthetic heart valves can have artificial leaflets. The prosthetic heart valves can be manufactured in numerous ways, such as by polymeric dipping processes.

公开(公告)号：US20150320555A1

公开(公告)日：2015-11-12

申请号：US14644936

申请日：2015-03-11

Applicant: FOLDAX, INC.

Inventor： Jason G. Beith

IPC: A61F2/24

CPC classification number: A61F2/2412 ,  A61F2/2409 ,  A61F2/2418 ,  A61F2220/0075 ,  A61F2230/0069

Abstract: A prosthetic valve has a support structure that meets with a plurality of leaflets capable of transitioning between open and closed states. The support structure can include a base frame with a polymer coating and the leaflets can be artificial. The interface between the support structure and each leaflet can be at least partially convex when viewed from an exterior of the support structure along a normal to a plane formed by a central axis of the support structure and a central axis of the leaflet.

公开(公告)号：US20210236275A1

公开(公告)日：2021-08-05

申请号：US17173061

申请日：2021-02-10

Applicant: Foldax, Inc.

Inventor： Jason G. Beith

IPC: A61F2/24

Abstract: A prosthetic valve has a support structure that meets with a plurality of leaflets capable of transitioning between open and closed states. The support structure can include a base frame with a polymer coating and the leaflets can be artificial. The interface between the support structure and each leaflet can be at least partially convex when viewed from an exterior of the support structure along a normal to a plane formed by a central axis of the support structure and a central axis of the leaflet.

公开(公告)号：US20170079782A1

公开(公告)日：2017-03-23

申请号：US15368312

申请日：2016-12-02

Applicant: FOLDAX, INC.

Inventor： Jason G. Beith

IPC: A61F2/24

CPC classification number: A61F2/2412 ,  A61F2/2409 ,  A61F2/2418 ,  A61F2220/0075 ,  A61F2230/0069

Abstract: A prosthetic valve has a support structure that meets with a plurality of leaflets capable of transitioning between open and closed states. The support structure can include a base frame with a polymer coating and the leaflets can be artificial. The interface between the support structure and each leaflet can be at least partially convex when viewed from an exterior of the support structure along a normal to a plane formed by a central axis of the support structure and a central axis of the leaflet.

公开(公告)号：US11534293B2

公开(公告)日：2022-12-27

申请号：US16266579

申请日：2019-02-04

Applicant: FOLDAX, INC.

Inventor： Jason G. Beith

IPC: A61F2/24

Abstract: Prosthetic heart valves having elastic leaflets and an elastic support structure are described. The support structure can store a load transferred from the leaflets as potential energy and then release it in the form of kinetic energy to exhibit a precursory transition from the closed position to the open position. The support structures can exhibit a sinusoidal movement profile at a base edge during the precursory transition.

公开(公告)号：US11129712B2

公开(公告)日：2021-09-28

申请号：US16551158

申请日：2019-08-26

Applicant: FOLDAX, INC.

Inventor： Jason G. Beith

IPC: A61F2/24

Abstract: Prosthetic heart valves having elastic leaflets and an elastic support structure are described. The support structure can store a load transferred from the leaflets as potential energy and then release it in the form of kinetic energy to exhibit a precursory transition from the closed position to the open position. The support structures can exhibit a sinusoidal movement profile at a base edge during the precursory transition.

公开(公告)号：US09301837B2

公开(公告)日：2016-04-05

申请号：US14644936

申请日：2015-03-11

Applicant: FOLDAX, INC.

Inventor： Jason G. Beith

IPC: A61F2/24 ,  A61F2/06

CPC classification number: A61F2/2412 ,  A61F2/2409 ,  A61F2/2418 ,  A61F2220/0075 ,  A61F2230/0069

Abstract: A prosthetic valve has a support structure that meets with a plurality of leaflets capable of transitioning between open and closed states. The support structure can include a base frame with a polymer coating and the leaflets can be artificial. The interface between the support structure and each leaflet can be at least partially convex when viewed from an exterior of the support structure along a normal to a plane formed by a central axis of the support structure and a central axis of the leaflet.

Abstract translation: 假体瓣膜具有与能够在打开和关闭状态之间转变的多个传单相遇的支撑结构。 支撑结构可以包括具有聚合物涂层的基架，并且传单可以是人造的。 当从支撑结构的外部沿着由支撑结构的中心轴线和叶片的中心轴线形成的平面的法线观察时，支撑结构和每个叶片之间的界面可以至少部分地是凸起的。