公开(公告)号：US20240350655A1

公开(公告)日：2024-10-24

申请号：US18556602

申请日：2022-04-22

申请人： FORSCHUNGSVERBUND BERLIN E.V.

发明人： Christian Ewald STIEGER ,  Christian Peter Richard HACKENBERGER ,  Marc-André KASPER ,  Philipp OCHTROP

IPC分类号： A61K47/68 ,  A61K47/54 ,  C07F9/32 ,  C07F9/6518 ,  C07F9/6524 ,  C07F9/653 ,  C07F9/6558 ,  C07F9/6561

CPC分类号： A61K47/6851 ,  A61K47/548 ,  A61K47/68031 ,  C07F9/3217 ,  C07F9/6518 ,  C07F9/6524 ,  C07F9/65324 ,  C07F9/65583 ,  C07F9/65586 ,  C07F9/6561

摘要： Disclosed are novel conjugates and methods for the preparation thereof. One of the methods for the preparation of a conjugate comprises a step of: acting a compound of formula (I), with a thiol-containing molecule of formula (II), wherein represents an amino acid, a peptide, a protein, an antibody, a nucleotide, an oligonucleotide, a saccharide, a polysaccharide, a polymer, a small molecule, an optionally substituted C1-C8-alkyl, an optionally substituted phenyl, or an optionally substituted aromatic 5- or 6-membered heterocyclic system; resulting in a compound of formula (III).