公开(公告)号：US20150046191A1

公开(公告)日：2015-02-12

申请号：US14463073

申请日：2014-08-19

Applicant: FOUNDATION MEDICINE, INC.

Inventor： Helena Futscher de Deus ,  Rachel Lauren Erlich ,  Ronald David Collette ,  Alexander N. Parker ,  Michael Pellini ,  Gary Palmer ,  Mary Pat Lancelotta ,  Matthew J. Hawryluk ,  Philip James Stephens ,  Eric Karl Neumann ,  Jeffrey B. Collemer

IPC: G06F19/00

CPC classification number: G16H10/60 ,  G06F19/3456 ,  G06Q50/24 ,  G16C99/00 ,  G16H15/00

Abstract: Various embodiments provide interfaces to access genomic testing information and incorporate it into daily physician practice. According to one aspect, a graph-based data model is used that may be used to organizes and revise precision medicine knowledge. In one example structure, gene states are abstracted into alteration groups, where alteration groups are built using reverse engineering actionable information and storing that information within the graph-based data structure. Volumes of genomic alterations and associated information (e.g., journal articles, clinical trial information, therapies, etc.) are analyzed and synthesized into actionable information items viewable on an alteration system in a graph-based data format. According to one embodiment, the system can be configured to focus practitioners on discrete portions of the alteration information on which they can act. According to other aspects, curated information is provided on the system to enable practitioners to make informed decisions regarding the implications of the presence of specific genomic alterations.