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公开(公告)号:US20180280391A1
公开(公告)日:2018-10-04
申请号:US15839560
申请日:2017-12-12
Applicant: FOUNDATION MEDICINE, INC.
Inventor: Sean R. Downing , Matthew J. Hawryluk , Doron Lipson , Alexander N. Parker , Philip James Stephens
IPC: A61K31/517 , C12N15/113 , A61K31/513 , C07K14/82 , A61K31/4412 , A61K31/404 , A61K31/47 , C12Q1/6886 , C12N9/14 , A61K31/444
Abstract: Novel RET fusion molecules and uses are disclosed.
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公开(公告)号:US09861633B2
公开(公告)日:2018-01-09
申请号:US14333368
申请日:2014-07-16
Applicant: FOUNDATION MEDICINE, INC.
Inventor: Siraj Mahamed Ali , Matthew J. Hawryluk , Jeffrey S. Ross , Philip James Stephens
IPC: C12Q1/68 , A61K31/517 , A61K47/48 , A61K31/5365 , C07K14/82 , C07K16/32 , A61K45/06 , A61K31/475 , A61K31/519 , A61K31/704 , A61K31/7105 , A61K31/713 , A61K33/24
CPC classification number: A61K31/517 , A61K31/475 , A61K31/519 , A61K31/5365 , A61K31/704 , A61K31/7105 , A61K31/713 , A61K33/24 , A61K45/06 , A61K47/6803 , A61K47/6851 , A61K47/6855 , C07K14/82 , C07K16/32 , C12Q1/6886 , C12Q2600/106 , A61K2300/00
Abstract: Methods and compositions for treating a urothelial and/or a micropapillary carcinoma, such as a micropapillary urothelial carcinoma are disclosed.
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3.
公开(公告)号:US20140037622A1
公开(公告)日:2014-02-06
申请号:US13958502
申请日:2013-08-02
Applicant: UCL Business PLC , FOUNDATION MEDICINE, INC.
Inventor: Chris Hendrik Boshoff , Timothy Robert Fenton , Matthias Alexander Lechner , Philip James Stephens , Matthew J. Hawryluk , Roman Yelensky , Garrett Michael Frampton
IPC: C12Q1/70 , A61K31/519 , A61K31/454 , A61K31/52 , A61K31/404 , A61K31/4196 , A61K33/24 , A61K31/282 , A61K31/337 , A61K31/513 , A61K39/395 , A61K31/436 , A61K31/05 , A61K31/4709 , A61K31/496 , A61K31/5377 , A61K31/352 , A61N5/00 , A61K31/506
CPC classification number: A61K31/519 , A61K31/05 , A61K31/282 , A61K31/337 , A61K31/352 , A61K31/366 , A61K31/404 , A61K31/4196 , A61K31/436 , A61K31/439 , A61K31/454 , A61K31/4709 , A61K31/4745 , A61K31/496 , A61K31/505 , A61K31/506 , A61K31/513 , A61K31/52 , A61K31/5377 , A61K31/555 , A61K33/24 , A61K39/39558 , A61K2039/505 , A61N5/00 , A61N5/10 , C07K16/2863 , C12Q1/6883 , C12Q1/6886 , C12Q1/708 , C12Q2600/106 , C12Q2600/118 , C12Q2600/156 , C12Q2600/158 , C12Q2600/16 , G01N33/571 , A61K2300/00
Abstract: Methods of treating a head and neck cancer are disclosed.
Abstract translation: 公开了治疗头颈癌的方法。
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公开(公告)号:US11771698B2
公开(公告)日:2023-10-03
申请号:US17204830
申请日:2021-03-17
Applicant: Foundation Medicine, Inc.
Inventor: Siraj Mahamed Ali , Matthew J. Hawryluk , Jie He , Doron Lipson , Vincent A. Miller , Jeffrey S. Ross , Philip James Stephens
IPC: A61K31/517 , A61K31/498 , A61K31/19 , A61K31/5025 , C12N9/12 , A61K31/4412 , A61K45/06 , A61K31/47 , A61K31/435 , A61K31/506 , A61K31/519 , A61K31/4439 , A61K31/53 , A61K31/404 , A61K31/5383 , A61K31/496 , C12Q1/6886 , A61K31/553 , C07K14/705 , C07K14/71 , C07K16/40 , C12N15/113 , C12Q1/6883 , G01N33/573
CPC classification number: A61K31/5025 , A61K31/404 , A61K31/435 , A61K31/4412 , A61K31/4439 , A61K31/47 , A61K31/496 , A61K31/498 , A61K31/506 , A61K31/517 , A61K31/519 , A61K31/53 , A61K31/5383 , A61K31/553 , A61K45/06 , C07K14/705 , C07K14/71 , C07K16/40 , C12N9/12 , C12N15/1137 , C12Q1/6883 , C12Q1/6886 , C12Y207/10001 , G01N33/573 , C07K2319/00 , C12N2310/11 , C12N2310/12 , C12N2310/14 , C12Q2600/156 , C12Q2600/158 , G01N2333/912 , G01N2500/04
Abstract: Methods and compositions for treating cholangiocarcinoma.
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公开(公告)号:US11766439B2
公开(公告)日:2023-09-26
申请号:US17344777
申请日:2021-06-10
Applicant: FOUNDATION MEDICINE, INC. , UCL BUSINESS LTD
Inventor: Chris Hendrik Boshoff , Timothy Robert Fenton , Matthias Alexander Lechner , Philip James Stephens , Matthew J. Hawryluk , Garrett Michael Frampton , Roman Yelensky
IPC: A61K31/55 , A61K38/00 , A61K31/519 , C12Q1/70 , A61K31/506 , A61K31/454 , A61K31/52 , A61K31/404 , A61K31/4196 , A61K31/282 , A61K31/337 , A61K31/513 , A61K39/395 , A61K31/436 , A61K31/05 , A61K31/4709 , A61K31/496 , A61K31/5377 , A61K31/352 , A61N5/00 , C12Q1/6886 , A61K31/366 , A61K31/505 , A61K31/555 , A61K33/243 , A61K33/24 , A61K31/439 , A61K31/4745 , C07K16/28 , C12Q1/6883 , G01N33/571 , A61N5/10 , A61K39/00
CPC classification number: A61K31/519 , A61K31/05 , A61K31/282 , A61K31/337 , A61K31/352 , A61K31/366 , A61K31/404 , A61K31/4196 , A61K31/436 , A61K31/439 , A61K31/454 , A61K31/4709 , A61K31/4745 , A61K31/496 , A61K31/505 , A61K31/506 , A61K31/513 , A61K31/52 , A61K31/5377 , A61K31/555 , A61K33/24 , A61K33/243 , A61K39/39558 , A61N5/00 , A61N5/10 , C07K16/2863 , C12Q1/6883 , C12Q1/6886 , C12Q1/708 , G01N33/571 , A61K2039/505 , C12Q2600/106 , C12Q2600/118 , C12Q2600/156 , C12Q2600/158 , C12Q2600/16 , A61K31/404 , A61K2300/00 , A61K31/454 , A61K2300/00 , A61K31/506 , A61K2300/00 , A61K31/513 , A61K2300/00 , A61K31/519 , A61K2300/00 , A61K31/52 , A61K2300/00 , A61K33/24 , A61K2300/00 , A61K31/436 , A61K2300/00 , A61K31/05 , A61K2300/00 , A61K31/366 , A61K2300/00 , A61K31/505 , A61K2300/00 , A61K31/555 , A61K2300/00 , A61K31/337 , A61K2300/00 , A61K31/282 , A61K2300/00 , A61K31/4196 , A61K2300/00 , A61K31/4709 , A61K2300/00 , A61K31/496 , A61K2300/00 , A61K31/5377 , A61K2300/00 , A61K31/105 , A61K2300/00
Abstract: Methods of treating a head and neck cancer are disclosed.
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公开(公告)号:US11450438B2
公开(公告)日:2022-09-20
申请号:US16579496
申请日:2019-09-23
Applicant: FOUNDATION MEDICINE, INC.
Inventor: Michael Pellini , Gary Palmer , Mary Patricia Lancelotta , Matthew J. Hawryluk , Vincent A. Miller
Abstract: A system for tracking and analyzing cancer treatment and outcome information includes a user interface (UI) component for allowing selection of an alteration, an affected gene, an affected pathway, a tumor type, and/or a treatment; a processor configured to receive treatment information and outcome information associated with a patient population; organize the treatment information and the outcome information into at least one tuple; and generate outcome summary information; and an analysis component configured to compare a current patient record for a current patient to existing treatment information for the patient population, identify similar patients in the patient population based on information in the current patient record, and filter a grouping of similar patients; the processor is further configured to display, on the UI component, the outcome summary information; enable navigation within the treatment and outcome information; and identify, based on the outcome information, an appropriate treatment for the current patient.
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公开(公告)号:US20180338977A1
公开(公告)日:2018-11-29
申请号:US15873703
申请日:2018-01-17
Applicant: FOUNDATION MEDICINE, INC. , UCL Business PLC
Inventor: Chris Hendrik Boshoff , Timothy Robert Fenton , Matthias Alexander Lechner , Philip James Stephens , Matthew J. Hawryluk , Garrett Michael Frampton , Roman Yelensky
IPC: A61K31/519 , C12Q1/6886 , A61K31/496 , A61K31/4709 , A61K31/05 , A61K31/436 , A61K39/395 , A61K31/513 , A61K31/337 , A61K31/282 , A61K33/24 , A61K31/4196 , A61K31/404 , A61K31/52 , A61K31/454 , A61K31/506 , C12Q1/70 , A61N5/00 , A61K31/352 , A61N5/10 , G01N33/571 , A61K31/439 , A61K31/4745
Abstract: Methods of treating a head and neck cancer are disclosed.
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公开(公告)号:US20170014413A1
公开(公告)日:2017-01-19
申请号:US15045716
申请日:2016-02-17
Applicant: FOUNDATION MEDICINE, INC.
Inventor: Sean R. Downing , Matthew J. Hawryluk , Doron Lipson , Alexander N. Parker , Philip James Stephens
IPC: A61K31/517 , A61K31/47 , A61K31/513 , A61K31/4412 , A61K31/404
CPC classification number: A61K31/517 , A61K31/404 , A61K31/4412 , A61K31/444 , A61K31/47 , A61K31/513 , C07K14/82 , C07K2319/00 , C12N9/14 , C12N15/1135 , C12Q1/6886 , C12Q2600/136 , C12Q2600/156 , C12Q2600/158
Abstract: Novel RET fusion molecules and uses are disclosed. In one embodiment, a KIF5B-RET fusion includes an in-frame fusion of an exon of KIF5B (e.g., one or more exons encoding a kinesin motor domain or a fragment thereof) and an exon of RET (e.g., one or more exons encoding a RET tyrosine kinase domain or a fragment thereof). For example, the KIF5B-RET fusion can include an in-frame fusion of at least exon 15 of KIF5B or a fragment thereof (e.g., exons 1-15 of KIF5B or a fragment thereof) with at least exon 12 of RET or a fragment thereof (e.g., exons 12-20 of RET or a fragment thereof).
Abstract translation: 公开了新型RET融合分子和用途。 在一个实施方案中,KIF5B-RET融合包括KIF5B的外显子(例如,编码驱动蛋白运动区或其片段的一个或多个外显子)和RET的外显子(例如,一个或多个外显子编码 RET酪氨酸激酶结构域或其片段)。 例如,KIF5B-RET融合可以包括至少外显子15的KIF5B或其片段(例如,KIF5B的外显子1-15或其片段)与至少外显子12的RET或片段的片段内融合 (例如,RET的外显子12-20或其片段)。
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公开(公告)号:US20160375025A1
公开(公告)日:2016-12-29
申请号:US15200088
申请日:2016-07-01
Applicant: FOUNDATION MEDICINE, INC. , UCL Business PLC
Inventor: Chris Hendrik Boshoff , Timothy Robert Fenton , Matthias Alexander Lechner , Philip James Stephens , Matthew J. Hawryluk , Garrett Michael Frampton , Roman Yelensky
IPC: A61K31/519 , C12Q1/68 , A61N5/10 , A61K31/506
CPC classification number: A61K31/519 , A61K31/05 , A61K31/282 , A61K31/337 , A61K31/352 , A61K31/366 , A61K31/404 , A61K31/4196 , A61K31/436 , A61K31/439 , A61K31/454 , A61K31/4709 , A61K31/4745 , A61K31/496 , A61K31/505 , A61K31/506 , A61K31/513 , A61K31/52 , A61K31/5377 , A61K31/555 , A61K33/24 , A61K39/39558 , A61K2039/505 , A61N5/00 , A61N5/10 , C07K16/2863 , C12Q1/6883 , C12Q1/6886 , C12Q1/708 , C12Q2600/106 , C12Q2600/118 , C12Q2600/156 , C12Q2600/158 , C12Q2600/16 , G01N33/571 , A61K2300/00
Abstract: Methods of treating a head and neck cancer are disclosed.
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10.
公开(公告)号:US20140337052A1
公开(公告)日:2014-11-13
申请号:US14146742
申请日:2014-01-03
Applicant: FOUNDATION MEDICINE, INC.
Inventor: Michael Pellini , Gary Palmer , Mary P. Lancelotta , Matthew J. Hawryluk , Vincent A. Miller
IPC: G06F19/00
Abstract: Provided are systems and methods for capturing outcome information associated with various cancer treatments. The system facilitates capture and analysis of cancer treatment information and associated outcome information. The treatment and outcome information can include genomic analysis and information on treatment of different cancers. The system can store and analyze any one or more of: tumor type, genomic alterations (e.g., genes and associated alterations, gene sequence mutations, alterations, amplifications, deletions, etc.), and treatment data (including, for example, treatments targeted to specific genes and/or genomic alterations). Users of the outcome system can supply and use the treatment and outcome information to facilitate diagnosis and therapy decisions. User interfaces within the system can be configured to allow users to easily locate outcome information associated with particular treatments of tumors having certain genomic alterations.
Abstract translation: 提供了用于捕获与各种癌症治疗相关的结果信息的系统和方法。 该系统有助于捕获和分析癌症治疗信息和相关的结果信息。 治疗和结果信息可以包括基因组分析和治疗不同癌症的信息。 该系统可以存储和分析以下中的一种或多种:肿瘤类型,基因组改变(例如,基因和相关的改变,基因序列突变,改变,扩增,缺失等)和治疗数据(包括例如靶向治疗 到特定基因和/或基因组改变)。 结果系统的用户可以提供和使用治疗和结果信息来促进诊断和治疗决策。 可以将系统内的用户界面配置为允许用户轻松定位与具有某些基因组改变的肿瘤的特定治疗相关联的结果信息。
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