公开(公告)号：US20150283094A1

公开(公告)日：2015-10-08

申请号：US14426713

申请日：2013-09-05

Applicant: FREIE UNIVERSITÄT BERLIN ,  LUDWIG-MAXIMILIANS-UNIVRSITÄT

Inventor： Rainer Haag ,  Dirk Steinhilber ,  Wolfgang Friess ,  Sarah Hedtrich (Born Küchler) ,  Madeleine Witting

IPC: A61K9/51 ,  A61K38/38 ,  C07K16/00 ,  A61K38/50

CPC classification number: A61K9/5146 ,  A61K9/06 ,  A61K9/5192 ,  A61K38/385 ,  A61K38/50 ,  B01J13/0065 ,  C07K16/00 ,  C12Y302/01017 ,  C12Y305/01001

Abstract: A method for producing a polyglycerol nanogel is disclosed, the method comprising the following steps: Mixing an aqueous solution of first polyglycerol macromonomers, which are modified with a first reactive group, with an aqueous solution of second polyglycerol macromonomers, which are modified with a second reactive group, wherein the first reactive group and the second reactive group can react with each other forming a chemical bond; transferring the mixture into an organic non-solvent; and precipitation of a polyglycerol nanogel consisting of first polyglycerol macromonomers and second polyglycerol macromonomers which are covalently bound to each other. According to an aspect of the invention, the method is characterized in that the organic non-solvent is miscible with water and in that the method is carried out without adding surface-active substances.

Abstract translation: 公开了一种聚甘油纳米凝胶的制造方法，该方法包括以下步骤：将第一聚甘油大分子单体的第一聚甘油大分子单体的水溶液与第二聚甘油大分子单体的水溶液混合， 反应性基团，其中第一反应性基团和第二反应性基团可以彼此反应形成化学键; 将混合物转移到有机非溶剂中; 和由共价键合的第一聚甘油大分子单体和第二聚甘油大分子单体组成的聚甘油纳米凝胶的沉淀。 根据本发明的一个方面，该方法的特征在于有机非溶剂与水混溶，并且该方法在不添加表面活性物质的情况下进行。

公开(公告)号：US09770420B2

公开(公告)日：2017-09-26

申请号：US14426713

申请日：2013-09-05

Applicant: FREIE UNIVERSITÄT BERLIN

Inventor： Rainer Haag ,  Dirk Steinhilber ,  Wolfgang Friess ,  Sarah Küchler ,  Madeleine Witting

IPC: A61K9/51 ,  A61K38/38 ,  C07K16/00 ,  B01J13/00 ,  A61K9/06 ,  A61K38/50

CPC classification number: A61K9/5146 ,  A61K9/06 ,  A61K9/5192 ,  A61K38/385 ,  A61K38/50 ,  B01J13/0065 ,  C07K16/00 ,  C12Y302/01017 ,  C12Y305/01001

Abstract: A method for producing a polyglycerol nanogel is disclosed, the method comprising the following steps: Mixing an aqueous solution of first polyglycerol macromonomers, which are modified with a first reactive group, with an aqueous solution of second polyglycerol macromonomers, which are modified with a second reactive group, wherein the first reactive group and the second reactive group can react with each other forming a chemical bond; transferring the mixture into an organic non-solvent; and precipitation of a polyglycerol nanogel consisting of first polyglycerol macromonomers and second polyglycerol macromonomers which are covalently bound to each other. According to an aspect of the invention, the method is characterized in that the organic non-solvent is miscible with water and in that the method is carried out without adding surface-active substances.