公开(公告)号：US20180356399A1

公开(公告)日：2018-12-13

申请号：US15618151

申请日：2017-06-09

申请人： FUJIFILM Corporation ,  The General Hospital Corporation

发明人： Koju ITO ,  Chihaya KAKINUMA ,  Shinji MIMA ,  Daichi HIKIMOTO ,  Craig M Neville ,  Cathryn A Sundback

IPC分类号： G01N33/50

CPC分类号： G01N33/5088 ,  G01N33/5029 ,  G01N33/5064

摘要： The present disclosure provides a blood vessel model including: a pair of channel members, mutually opposing each other, each of which includes an opposing face in which a respective microchannel is formed; and a porous membrane that includes plural through-holes penetrating in a thickness direction, that is disposed between the opposing faces of the pair of channel members, and that partitions between the microchannels, wherein the porous membrane is provided with a vascular endothelial cell layer so as to cover one face facing one of the microchannels, an average opening diameter of the through-holes is from 1 μm to 20 μm, and an opening coverage ratio of the through-holes is from 30% to 70%.

公开(公告)号：US20180356398A1

公开(公告)日：2018-12-13

申请号：US15618150

申请日：2017-06-09

申请人： FUJIFILM Corporation ,  The General Hospital Corporation

发明人： Koju ITO ,  Chihaya KAKINUMA ,  Masafumi NISHINO ,  Shinji MIMA ,  Craig M Neville ,  Cathryn A Sundback

IPC分类号： G01N33/50

CPC分类号： G01N33/5088 ,  G01N33/5023 ,  G01N33/5044 ,  G01N33/5061 ,  G01N33/5064

摘要： A living tissue model device includes: a first liquid compartment storing a liquid composition; a second liquid compartment storing a liquid composition; and a cell layered body disposed between the first liquid compartment and the second liquid compartment, as a partition between both compartments. A vascular wall model includes: a porous membrane having a honeycomb structure; a vascular endothelial cell layer disposed on one face of the porous membrane; and a smooth muscle cell layer, or a mesenchymal stem cell layer, disposed on another face of the porous membrane. A vascular wall model device includes: a first liquid compartment storing a liquid composition; a second liquid compartment storing a liquid composition; and a vascular wall model disposed between the first liquid compartment and the second liquid compartment, as a partition between both compartments. Applications of these models or model devices are also provided.

公开(公告)号：US20180171324A1

公开(公告)日：2018-06-21

申请号：US15887083

申请日：2018-02-02

申请人： FUJIFILM Corporation

发明人： Kentaro NAKAMURA ,  Shinji MIMA ,  Tsukasa KITAHASHI ,  Chihaya KAKINUMA

IPC分类号： C12N11/02 ,  A01K67/027 ,  C12N5/095 ,  A61K49/00

CPC分类号： C12N11/02 ,  A01K67/0271 ,  A01K2207/12 ,  A01K2207/15 ,  A01K2207/30 ,  A01K2227/105 ,  A01K2267/0331 ,  A61K35/13 ,  A61K35/28 ,  A61K49/0008 ,  A61L27/00 ,  C12N5/0695 ,  C12N2533/54 ,  G01N33/50

摘要： An object of the present invention is to provide a non-human model animal rich in stromal tissue, a cell structure useful for producing the above-described non-human model animal, a method for evaluating a test substance in which the above-described non-human model animal is used, and a method for producing the above-described non-human model animal. According to the present invention, a cell structure is provided which contains a biocompatible macromolecular block and at least a cancer cell and a mesenchymal cell, and in which a plurality of the above-described biocompatible macromolecular blocks are arranged in gaps between a plurality of the above-described cells.