公开(公告)号：US20220370352A1

公开(公告)日：2022-11-24

申请号：US17882144

申请日：2022-08-05

申请人： FUJIFILM Corporation

发明人： Noriyuki Kasagi ,  Naoki Yamada ,  Mikinaga Mori ,  Takayuki Kato ,  Takayuki Kobayashi

IPC分类号： A61K9/127 ,  A61K31/4745 ,  A61K31/704 ,  A61K31/404

摘要： An object of the present invention is to provide a liposome composition and a pharmaceutical composition, which exhibit a high AUC. Provided are a liposome composition including a hydrophilic polymer-modified diacylphosphatidylethanolamine, a dihydrosphingomyelin, and cholesterols as components of a liposome membrane, in which the liposome composition encapsulates a drug, an inner water phase thereof contains ammonium sulfate, and a molar ratio of sulfate ions in the inner water phase to the drug in an entire water phase is 0.36 or more; and a pharmaceutical composition including the liposome composition.

公开(公告)号：US11446247B2

公开(公告)日：2022-09-20

申请号：US17079759

申请日：2020-10-26

申请人： FUJIFILM Corporation

发明人： Noriyuki Kasagi ,  Naoki Yamada ,  Mikinaga Mori ,  Takayuki Kato ,  Takayuki Kobayashi

IPC分类号： A61K9/127 ,  A61K33/02 ,  A61K47/28 ,  A61K31/4745

摘要： An object of the present invention is to provide a liposome composition and a pharmaceutical composition, which exhibit a high AUC. Provided are a liposome composition including a hydrophilic polymer-modified diacylphosphatidylethanolamine, a dihydrosphingomyelin, and cholesterols as components of a liposome membrane, in which the liposome composition encapsulates a drug, an inner water phase thereof contains ammonium sulfate, and a molar ratio of sulfate ions in the inner water phase to the drug in an entire water phase is 0.36 or more; and a pharmaceutical composition including the liposome composition.

公开(公告)号：US12005143B2

公开(公告)日：2024-06-11

申请号：US15868160

申请日：2018-01-11

申请人： FUJIFILM Corporation

发明人： Susumu Sugiyama ,  Naoki Yamada ,  Shigehisa Sugiyama ,  Yohei Okubo

IPC分类号： A61K9/127 ,  A61K31/7068 ,  B01F23/40 ,  B01F23/41 ,  B01F25/21 ,  B01F25/50 ,  B01J13/04 ,  B01J13/08 ,  B82Y5/00 ,  B82Y40/00 ,  B01F101/22

CPC分类号： A61K9/1277 ,  A61K9/127 ,  A61K9/1271 ,  A61K31/7068 ,  B01F23/40 ,  B01F23/41 ,  B01F25/21 ,  B01F25/50 ,  B01J13/04 ,  B01J13/08 ,  B82Y5/00 ,  B82Y40/00 ,  B01F2101/22

摘要： Disclosed herein are a method for producing a miniaturized liposome on a large production scale, and an apparatus for producing a liposome which is to be used in the above-mentioned method. Provided is a method for producing a liposome, including a step of stirring a mixture containing an oil phase in which at least one lipid is dissolved in an organic solvent and a water phase in a first tank of an apparatus having the first tank and a circulation path, in which the ratio of the capacity of the circulation path to the total capacity of the tank and the circulation path is 0.4 or less and/or the time required for the mixture to return to the first tank after being discharged therefrom is within 2.0 minutes.

公开(公告)号：US11413244B2

公开(公告)日：2022-08-16

申请号：US16583518

申请日：2019-09-26

申请人： FUJIFILM Corporation

发明人： Noriyuki Kasagi ,  Naoki Yamada ,  Mikinaga Mori ,  Takayuki Kato ,  Takayuki Kobayashi

IPC分类号： A61K9/127 ,  A61K33/02 ,  A61K47/28 ,  A61K31/4745

摘要： An object of the present invention is to provide a liposome composition and a pharmaceutical composition, which exhibit a high AUC. Provided are a liposome composition including a hydrophilic polymer-modified diacylphosphatidylethanolamine, a dihydrosphingomyelin, and cholesterols as components of a liposome membrane, in which the liposome composition encapsulates a drug, an inner water phase thereof contains ammonium sulfate, and a molar ratio of sulfate ions in the inner water phase to the drug in an entire water phase is 0.36 or more; and a pharmaceutical composition including the liposome composition.

公开(公告)号：US11325091B2

公开(公告)日：2022-05-10

申请号：US15625020

申请日：2017-06-16

申请人： FUJIFILM Corporation

发明人： Susumu Sugiyama ,  Naoki Yamada ,  Shigehisa Sugiyama ,  Yohei Okubo ,  Takashi Sasaki ,  Tetsu Ishiguro

IPC分类号： B01J13/04 ,  A61K9/127 ,  B01D1/00 ,  B01D5/00 ,  B01F3/08 ,  B01F5/10 ,  B01F7/00

摘要： Disclosed herein are a method for producing a liposome which is capable of reducing the facility costs and also capable of rapid desolvation, and an apparatus for producing a liposome which is for use in the above-mentioned method. Provided is a method for producing a liposome, including a stirring step of stirring a mixed liquid containing an oil phase in which at least one lipid is dissolved in an organic solvent and a water phase, and an evaporating step of evaporating an organic solvent from the mixed liquid, in which the condensed organic solvent is removed by passing a gas having a temperature not higher than the dew point of the solvent in the evaporating step.