公开(公告)号：US12049614B2

公开(公告)日：2024-07-30

申请号：US18337146

申请日：2023-06-19

Applicant: FUJIFILM CORPORATION

Inventor： Shinichi Nakai ,  Yoichi Nagai ,  Nobuyuki Haraguchi ,  Shigehisa Sugiyama

IPC: B01D61/14 ,  B01D61/18 ,  B01D61/58 ,  C12M1/00 ,  C12M1/12 ,  C12M1/26 ,  C12N5/00

CPC classification number: C12M29/04 ,  B01D61/145 ,  B01D61/147 ,  B01D61/149 ,  B01D61/18 ,  B01D61/58 ,  C12M29/10 ,  C12M29/18 ,  C12M33/14 ,  C12M37/02 ,  C12M39/00 ,  C12M47/02 ,  C12N5/0081 ,  B01D2311/2512 ,  B01D2311/2523 ,  B01D2311/2688 ,  B01D2315/08 ,  B01D2315/10 ,  B01D2317/025

Abstract: Provided is a cell culture apparatus including a culture vessel that stores a cell suspension containing cells; a first filter part that has a first filter membrane that performs membrane separation treatment on the cell suspension extracted from the culture vessel; a first circulation flow path that allows components blocked by the first filter membrane to return to the culture vessel; a second filter part that has a second filter membrane that performs membrane separation treatment on components of the cell suspension permeated through the first filter membrane; a second circulation flow path that allows components permeated through the second filter membrane to return to the culture vessel; and a recovery flow path that recovers components blocked by the second filter membrane. In the cell culture apparatus, an average hole diameter of the first filter membrane is 20 μm or smaller, and 0

公开(公告)号：US11325091B2

公开(公告)日：2022-05-10

申请号：US15625020

申请日：2017-06-16

Applicant: FUJIFILM Corporation

Inventor： Susumu Sugiyama ,  Naoki Yamada ,  Shigehisa Sugiyama ,  Yohei Okubo ,  Takashi Sasaki ,  Tetsu Ishiguro

IPC: B01J13/04 ,  A61K9/127 ,  B01D1/00 ,  B01D5/00 ,  B01F3/08 ,  B01F5/10 ,  B01F7/00

Abstract: Disclosed herein are a method for producing a liposome which is capable of reducing the facility costs and also capable of rapid desolvation, and an apparatus for producing a liposome which is for use in the above-mentioned method. Provided is a method for producing a liposome, including a stirring step of stirring a mixed liquid containing an oil phase in which at least one lipid is dissolved in an organic solvent and a water phase, and an evaporating step of evaporating an organic solvent from the mixed liquid, in which the condensed organic solvent is removed by passing a gas having a temperature not higher than the dew point of the solvent in the evaporating step.

公开(公告)号：US12005143B2

公开(公告)日：2024-06-11

申请号：US15868160

申请日：2018-01-11

Applicant: FUJIFILM Corporation

Inventor： Susumu Sugiyama ,  Naoki Yamada ,  Shigehisa Sugiyama ,  Yohei Okubo

IPC: A61K9/127 ,  A61K31/7068 ,  B01F23/40 ,  B01F23/41 ,  B01F25/21 ,  B01F25/50 ,  B01J13/04 ,  B01J13/08 ,  B82Y5/00 ,  B82Y40/00 ,  B01F101/22

CPC classification number: A61K9/1277 ,  A61K9/127 ,  A61K9/1271 ,  A61K31/7068 ,  B01F23/40 ,  B01F23/41 ,  B01F25/21 ,  B01F25/50 ,  B01J13/04 ,  B01J13/08 ,  B82Y5/00 ,  B82Y40/00 ,  B01F2101/22

Abstract: Disclosed herein are a method for producing a miniaturized liposome on a large production scale, and an apparatus for producing a liposome which is to be used in the above-mentioned method. Provided is a method for producing a liposome, including a step of stirring a mixture containing an oil phase in which at least one lipid is dissolved in an organic solvent and a water phase in a first tank of an apparatus having the first tank and a circulation path, in which the ratio of the capacity of the circulation path to the total capacity of the tank and the circulation path is 0.4 or less and/or the time required for the mixture to return to the first tank after being discharged therefrom is within 2.0 minutes.

公开(公告)号：US11725174B2

公开(公告)日：2023-08-15

申请号：US16460983

申请日：2019-07-02

Applicant: FUJIFILM CORPORATION

Inventor： Shinichi Nakai ,  Yoichi Nagai ,  Nobuyuki Haraguchi ,  Shigehisa Sugiyama

IPC: B01D61/14 ,  B01D61/18 ,  C12M1/00 ,  C12M1/12 ,  C12M1/26 ,  B01D61/58 ,  C12N5/00

CPC classification number: C12M29/04 ,  B01D61/145 ,  B01D61/146 ,  B01D61/147 ,  B01D61/18 ,  B01D61/58 ,  C12M29/10 ,  C12M29/18 ,  C12M33/14 ,  C12M37/02 ,  C12M39/00 ,  C12M47/02 ,  C12N5/0081 ,  B01D2311/25 ,  B01D2311/2688 ,  B01D2315/08 ,  B01D2315/10 ,  B01D2317/025

Abstract: Provided is a cell culture apparatus including a culture vessel that stores a cell suspension containing cells; a first filter part that has a first filter membrane that performs membrane separation treatment on the cell suspension extracted from the culture vessel; a first circulation flow path that allows components blocked by the first filter membrane to return to the culture vessel; a second filter part that has a second filter membrane that performs membrane separation treatment on components of the cell suspension permeated through the first filter membrane; a second circulation flow path that allows components permeated through the second filter membrane to return to the culture vessel; and a recovery flow path that recovers components blocked by the second filter membrane. In the cell culture apparatus, an average hole diameter of the first filter membrane is 20 μm or smaller, and 0

公开(公告)号：US10052807B2

公开(公告)日：2018-08-21

申请号：US15231094

申请日：2016-08-08

Applicant: FUJIFILM Corporation

Inventor： Yukihiro Katai ,  Shigehisa Sugiyama ,  Seiji Kasahara ,  Yasuhisa Shimoda ,  Masahiro Esaki

IPC: D01D5/06 ,  D01D5/11 ,  D01F2/28 ,  D01F13/02 ,  D04H1/4258 ,  D04H1/72 ,  D04H1/736 ,  D21H13/02 ,  B29C47/00 ,  B29B11/04 ,  B29K1/00 ,  B29L7/00

CPC classification number: B29C48/08 ,  B29B11/04 ,  B29C48/05 ,  B29K2001/12 ,  B29L2007/008 ,  D01D5/06 ,  D01F2/28 ,  D01F13/02 ,  D04H1/4258 ,  D04H1/72 ,  D04H1/736 ,  D21H13/02 ,  Y02P70/627

Abstract: A fiber manufacturing method includes the following steps of: dissolving a polymer in a solvent to obtain a polymer solution; spraying the polymer solution into a liquid heated to a boiling point of the solvent or higher, and evaporating the solvent to precipitate a fibrous polymer in a sealed precipitation tank, the liquid being immiscible with the polymer and the solvent; conveying the precipitated fibrous polymer in a liquid from the precipitation tank; water-rinsing the fibrous polymer conveyed in the liquid in the conveying step in a sealed water-rinsing tank; conveying the water-rinsed fibrous polymer in a liquid from the water-rinsing tank; and cooling and condensing solvent gas that is generated in the spraying step and the water-rinsing step.