公开(公告)号：US20210213040A1

公开(公告)日：2021-07-15

申请号：US17213567

申请日：2021-03-26

Applicant: FUJIFILM Corporation

Inventor： Satoshi KITAZAWA ,  Yukiko ISHII ,  Koichi SAITO ,  Shun MATSUDA

IPC: A61K31/7068 ,  A61K45/06 ,  A61K31/455

Abstract: An object of the present invention is to provide a combination drug containing cytarabine and a DHODH inhibitor, as a new anti-tumor agent, and to provide an anti-tumor effect enhancing agent which is used in combination with cytarabine, an anti-tumor kit, and an anti-tumor agent which is used in combination with cytarabine. According to the present invention, an anti-tumor agent and an anti-tumor kit containing cytarabine and a dihydroorotate dehydrogenase inhibitor compound are provided.

公开(公告)号：US20240361332A1

公开(公告)日：2024-10-31

申请号：US18764888

申请日：2024-07-05

Applicant: FUJIFILM Corporation

Inventor： Shun MATSUDA

IPC: G01N33/68 ,  G01N33/58

CPC classification number: G01N33/6848 ,  G01N33/58 ,  G01N2333/015

Abstract: An object of the present invention is to provide a method of identifying an amino acid site in a protein, to which a sugar is bound more accurately than in the related art, and a kit for performing the method. According to the present invention, there is provided a method for identifying an amino acid site in a protein, to which a sugar is bonded, the method including a first mass spectrometry step of subjecting a fragmented protein to mass spectrometry; for a protein in which the bonding of the sugar has been confirmed in the first mass spectrometry step, a substitution-modification step of substituting and/or modifying an amino acid of the protein at the amino acid site in the protein, to which the sugar is bonded and a fragmentation step of fragmenting the protein; and a second mass spectrometry step of subjecting the substituted and/or modified, and fragmented protein obtained by the substitution-modification step and the fragmentation step, to mass spectrometry.