公开(公告)号：US12285525B2

公开(公告)日：2025-04-29

申请号：US17112239

申请日：2020-12-04

Applicant: FUJIFILM Corporation

Inventor： Shintaro Tanabe ,  Masahiko Yamamoto ,  Kimihiko Sato ,  Motomasa Takahashi ,  Kazuhiro Tsuna ,  Yasutaka Tasaki ,  Taisuke Endo ,  Issei Doi ,  Hirofumi Fukunaga

IPC: A61K9/127 ,  A61K9/1272 ,  A61K9/1278 ,  C07C219/06 ,  C12N15/88

Abstract: An object of the present invention is to provide a compound or a salt thereof constituting lipid particles that can achieve a high nucleic acid encapsulation rate and excellent delivery of nucleic acids, and to provide lipid particles that can achieve a high nucleic acid encapsulation rate and excellent delivery of nucleic acids. According to an aspect of the present invention, a compound represented by Formula (1) or a salt thereof is provided. In the formula, X represents —NR1— or —O—, R1 represents a hydrogen atom, a hydrocarbon group, or the like, R2 and R3 each independently represent a hydrogen atom, a hydrocarbon group, or the like, R4, R5, R6, R7, R8, R9, R10, R11, and R12 each independently represent a hydrogen atom or an alkyl group, groups in any one or more pairs among R4 and R5, R10 and R5, R5 and R12, R4 and R6, R5 and R6, R6 and R7, R6 and R10, R12 and R7, and R7 and R8 may be linked to each other to form a 4- to 7-membered ring which may contain an O atom, a, b, c, and d are each independently represent an integer of 0 to 3, a+b is equal to or greater than 1, and c+d is equal to or greater than 1.

公开(公告)号：US09624215B2

公开(公告)日：2017-04-18

申请号：US14440010

申请日：2013-10-30

Applicant: TOYAMA CHEMICAL CO., LTD. ,  FUJIFILM CORPORATION

Inventor： Tadashi Tanaka ,  Yoshitake Konishi ,  Daisuke Kubo ,  Masataka Fujino ,  Issei Doi ,  Daisuke Nakagawa ,  Tatsuya Murakami ,  Takayuki Yamakawa

IPC: A61K31/455 ,  A61K31/4709 ,  A61K31/497 ,  A61K31/501 ,  C07D235/26 ,  C07D403/04 ,  C07D413/12 ,  C07D417/04 ,  C07D241/44 ,  C07D263/58 ,  C07D209/08 ,  C07D277/68 ,  C07D471/04 ,  C07D403/12 ,  C07D401/14 ,  C07D405/14 ,  A61K31/4035 ,  A61K31/404 ,  A61K31/416 ,  A61K31/4184 ,  A61K31/423 ,  A61K31/427 ,  A61K31/428 ,  A61K31/437 ,  A61K31/4439 ,  A61K31/454 ,  A61K31/4725 ,  A61K31/498 ,  A61K31/506 ,  A61K31/517 ,  A61K31/5377 ,  A61K31/538 ,  C07D213/80 ,  C07D215/38 ,  C07D217/24 ,  C07D231/56 ,  C07D401/04 ,  C07D235/08 ,  C07D401/06 ,  C07D401/12 ,  C07D417/06 ,  C07D417/12 ,  C07D209/12 ,  C07D209/34 ,  C07D209/38 ,  C07D209/42 ,  C07D209/46 ,  C07D209/48 ,  C07C211/45 ,  C07D209/04 ,  C07D215/227 ,  C07D239/88 ,  C07D265/36 ,  C07D401/10 ,  C07D407/14 ,  C07D413/06 ,  C07D413/10 ,  C07D413/14

CPC classification number: C07D471/04 ,  A61K31/4035 ,  A61K31/404 ,  A61K31/416 ,  A61K31/4184 ,  A61K31/423 ,  A61K31/427 ,  A61K31/428 ,  A61K31/437 ,  A61K31/4439 ,  A61K31/454 ,  A61K31/455 ,  A61K31/4709 ,  A61K31/4725 ,  A61K31/497 ,  A61K31/498 ,  A61K31/501 ,  A61K31/506 ,  A61K31/517 ,  A61K31/5377 ,  A61K31/538 ,  C07C211/45 ,  C07D209/04 ,  C07D209/08 ,  C07D209/12 ,  C07D209/34 ,  C07D209/38 ,  C07D209/42 ,  C07D209/46 ,  C07D209/48 ,  C07D213/80 ,  C07D215/227 ,  C07D215/38 ,  C07D217/24 ,  C07D231/56 ,  C07D235/08 ,  C07D235/26 ,  C07D239/88 ,  C07D241/44 ,  C07D263/58 ,  C07D265/36 ,  C07D277/68 ,  C07D401/04 ,  C07D401/06 ,  C07D401/10 ,  C07D401/12 ,  C07D401/14 ,  C07D403/04 ,  C07D403/12 ,  C07D405/14 ,  C07D407/14 ,  C07D413/06 ,  C07D413/10 ,  C07D413/12 ,  C07D413/14 ,  C07D417/04 ,  C07D417/06 ,  C07D417/12 ,  Y02P20/55

Abstract: A novel amine derivative expressed by general formula (1) (in the formula: G1, G2, and G3 are the same or different and represent CH or a nitrogen atom; R1 represents a chlorine atom, an optionally-substituted C3-8 cycloalkyl group, or the like; R2 represents —COOR5 (in the formula, R5 represents a hydrogen atom or a carboxyl protective group), or the like; R3 represents a hydrogen atom, or the like; and R4 represents an optionally-substituted condensed bicyclic hydrocarbon group, an optionally-substituted bicyclic heterocyclic group, or the like), or a salt thereof is useful in procedures such as the treatment or prevention of conditions related to excessive keratinocyte proliferation.

公开(公告)号：US20150299189A1

公开(公告)日：2015-10-22

申请号：US14440010

申请日：2013-10-30

Applicant: TOYAMA CHEMICAL CO., LTD. ,  FUJIFILM CORPORATION

Inventor： Tadashi Tanaka ,  Yoshitake Konishi ,  Daisuke Kubo ,  Masataka Fujino ,  Issei Doi ,  Daisuke Nakagawa ,  Tatsuya Murakami ,  Takayuki Yamakawa

IPC: C07D471/04 ,  C07D215/227 ,  C07D217/24 ,  C07D213/80 ,  C07D263/58 ,  C07C211/45 ,  C07D241/44 ,  C07D239/88 ,  C07D265/36 ,  C07D401/10 ,  C07D413/10 ,  C07D401/12 ,  C07D413/06 ,  C07D417/04 ,  C07D413/12 ,  C07D403/04 ,  C07D401/04 ,  C07D413/14 ,  C07D403/12 ,  C07D407/14 ,  C07D401/14 ,  C07D417/12 ,  C07D209/04

CPC classification number: C07D471/04 ,  A61K31/4035 ,  A61K31/404 ,  A61K31/416 ,  A61K31/4184 ,  A61K31/423 ,  A61K31/427 ,  A61K31/428 ,  A61K31/437 ,  A61K31/4439 ,  A61K31/454 ,  A61K31/455 ,  A61K31/4709 ,  A61K31/4725 ,  A61K31/497 ,  A61K31/498 ,  A61K31/501 ,  A61K31/506 ,  A61K31/517 ,  A61K31/5377 ,  A61K31/538 ,  C07C211/45 ,  C07D209/04 ,  C07D209/08 ,  C07D209/12 ,  C07D209/34 ,  C07D209/38 ,  C07D209/42 ,  C07D209/46 ,  C07D209/48 ,  C07D213/80 ,  C07D215/227 ,  C07D215/38 ,  C07D217/24 ,  C07D231/56 ,  C07D235/08 ,  C07D235/26 ,  C07D239/88 ,  C07D241/44 ,  C07D263/58 ,  C07D265/36 ,  C07D277/68 ,  C07D401/04 ,  C07D401/06 ,  C07D401/10 ,  C07D401/12 ,  C07D401/14 ,  C07D403/04 ,  C07D403/12 ,  C07D405/14 ,  C07D407/14 ,  C07D413/06 ,  C07D413/10 ,  C07D413/12 ,  C07D413/14 ,  C07D417/04 ,  C07D417/06 ,  C07D417/12 ,  Y02P20/55

Abstract: A novel amine derivative expressed by general formula (1) (in the formula: G1, G2, and G3 are the same or different and represent CH or a nitrogen atom; R1 represents a chlorine atom, an optionally-substituted C3-8 cycloalkyl group, or the like; R2 represents —COOR5 (in the formula, R5 represents a hydrogen atom or a carboxyl protective group), or the like; R3 represents a hydrogen atom, or the like; and R4 represents an optionally-substituted condensed bicyclic hydrocarbon group, an optionally-substituted bicyclic heterocyclic group, or the like), or a salt thereof is useful in procedures such as the treatment or prevention of conditions related to excessive keratinocyte proliferation.

Abstract translation: 由通式（1）表示的新型胺衍生物（式中，G1，G2和G3相同或不同，表示CH或氮原子; R1表示氯原子，任意取代的C3-8环烷基 等; R 2表示-COOR 5（式中，R5表示氢原子或羧基保护基）等; R3表示氢原子等; R4表示任选取代的稠合双环烃 基团，任选取代的双环杂环基等）或其盐可用于诸如治疗或预防与过度角质形成细胞增殖相关的病症的过程。