公开(公告)号：US20200016079A1

公开(公告)日：2020-01-16

申请号：US16583518

申请日：2019-09-26

Applicant: FUJIFILM Corporation

Inventor： Noriyuki KASAGI ,  Naoki YAMADA ,  Mikinaga MORI ,  Takayuki KATO ,  Takayuki KOBAYASHI

IPC: A61K9/127 ,  A61K47/28 ,  A61K33/02

Abstract: An object of the present invention is to provide a liposome composition and a pharmaceutical composition, which exhibit a high AUC. Provided are a liposome composition including a hydrophilic polymer-modified diacylphosphatidylethanolamine, a dihydrosphingomyelin, and cholesterols as components of a liposome membrane, in which the liposome composition encapsulates a drug, an inner water phase thereof contains ammonium sulfate, and a molar ratio of sulfate ions in the inner water phase to the drug in an entire water phase is 0.36 or more; and a pharmaceutical composition including the liposome composition.

公开(公告)号：US20210038518A1

公开(公告)日：2021-02-11

申请号：US17079759

申请日：2020-10-26

Applicant: FUJIFILM Corporation

Inventor： Noriyuki KASAGI ,  Naoki YAMADA ,  Mikinaga MORI ,  Takayuki KATO ,  Takayuki KOBAYASHI

IPC: A61K9/127 ,  A61K33/02 ,  A61K47/28

Abstract: An object of the present invention is to provide a liposome composition and a pharmaceutical composition, which exhibit a high AUC. Provided are a liposome composition including a hydrophilic polymer-modified diacylphosphatidylethanolamine, a dihydrosphingomyelin, and cholesterols as components of a liposome membrane, in which the liposome composition encapsulates a drug, an inner water phase thereof contains ammonium sulfate, and a molar ratio of sulfate ions in the inner water phase to the drug in an entire water phase is 0.36 or more; and a pharmaceutical composition including the liposome composition.