公开(公告)号：US20200016079A1

公开(公告)日：2020-01-16

申请号：US16583518

申请日：2019-09-26

Applicant: FUJIFILM Corporation

Inventor： Noriyuki KASAGI ,  Naoki YAMADA ,  Mikinaga MORI ,  Takayuki KATO ,  Takayuki KOBAYASHI

IPC: A61K9/127 ,  A61K47/28 ,  A61K33/02

Abstract: An object of the present invention is to provide a liposome composition and a pharmaceutical composition, which exhibit a high AUC. Provided are a liposome composition including a hydrophilic polymer-modified diacylphosphatidylethanolamine, a dihydrosphingomyelin, and cholesterols as components of a liposome membrane, in which the liposome composition encapsulates a drug, an inner water phase thereof contains ammonium sulfate, and a molar ratio of sulfate ions in the inner water phase to the drug in an entire water phase is 0.36 or more; and a pharmaceutical composition including the liposome composition.

公开(公告)号：US20180372737A1

公开(公告)日：2018-12-27

申请号：US16115594

申请日：2018-08-29

Applicant: FUJIFILM Corporation

Inventor： Noriyuki KASAGI ,  Hiroyuki CHIKU ,  Ayumi ERA

IPC: G01N33/543

Abstract: An object of the present invention is to provide a kit for quantitatively determining a bile acid, in which it is possible to improve measurement accuracy by sufficiently dissociating the bile acid from a polymer component, and to rapidly carry out the quantitative determination of the bile acid with high accuracy under various environments, and a method for quantitatively determining the bile acid.According to the present invention, a kit for quantitatively determining a bile acid in a biological sample, including a compound represented by General Formula (I) defined in the present specification in a dry state; a fluorescent particle that has a first binding substance capable of binding to the bile acid; and a substrate that has a detection region having a second binding substance capable of binding to any one of the bile acid and the first binding substance, is provided.

公开(公告)号：US20180372731A1

公开(公告)日：2018-12-27

申请号：US16115595

申请日：2018-08-29

Applicant: FUJIFILM Corporation

Inventor： Hiroyuki CHIKU ,  Noriyuki KASAGI

IPC: G01N33/543 ,  G01N21/64

Abstract: An object of the present invention is to provide a kit in which a quantitative determination of a substance to be measured in a biological sample can be carried out with high accuracy, even in a case where the substance to be measured includes a plurality of substances having different structures. According to the present invention, a kit for quantitatively determining a substance to be measured in a biological sample, the kit including fluorescent particles that have a first binding substance capable of binding to the substance to be measured; and a substrate that has a detection region having a second binding substance capable of binding to any one of the substance to be measured and the first binding substance, in which the substance to be measured includes at least three types of substances having different structures, and the first binding substance includes at least three types of binding substances which are capable of binding to the at least three types of substances having different structures, respectively, is provided.

公开(公告)号：US20180372638A1

公开(公告)日：2018-12-27

申请号：US16115593

申请日：2018-08-29

Applicant: FUJIFILM Corporation

Inventor： Noriyuki KASAGI ,  Hiroyuki CHIKU

IPC: G01N21/64 ,  G01N33/553 ,  G01N33/531

Abstract: An object of the present invention is to provide a kit and a method by which a quantitative determination of a substance to be measured in a biological sample can be carried out with high accuracy while avoiding the influence of an antibody such as an anti-serum albumin antibody present in blood. According to the present invention, a kit for quantitatively determining a substance to be measured in a biological sample, the kit including: a labeled particle that has a first binding substance capable of binding to the substance to be measured, and a first blocking agent; and a substrate that has a detection region having a second binding substance capable of binding to any one of the substance to be measured and the first binding substance, and a second blocking agent, in which the first blocking agent and the second blocking agent are different from each other, is provided.

公开(公告)号：US20210038518A1

公开(公告)日：2021-02-11

申请号：US17079759

申请日：2020-10-26

Applicant: FUJIFILM Corporation

Inventor： Noriyuki KASAGI ,  Naoki YAMADA ,  Mikinaga MORI ,  Takayuki KATO ,  Takayuki KOBAYASHI

IPC: A61K9/127 ,  A61K33/02 ,  A61K47/28

Abstract: An object of the present invention is to provide a liposome composition and a pharmaceutical composition, which exhibit a high AUC. Provided are a liposome composition including a hydrophilic polymer-modified diacylphosphatidylethanolamine, a dihydrosphingomyelin, and cholesterols as components of a liposome membrane, in which the liposome composition encapsulates a drug, an inner water phase thereof contains ammonium sulfate, and a molar ratio of sulfate ions in the inner water phase to the drug in an entire water phase is 0.36 or more; and a pharmaceutical composition including the liposome composition.

公开(公告)号：US20160069909A1

公开(公告)日：2016-03-10

申请号：US14840710

申请日：2015-08-31

Applicant: FUJIFILM Corporation

Inventor： Kazuhiro NAKAMURA ,  Noriyuki KASAGI ,  Hiroyuki CHIKU ,  Kentaro NAKAMURA

IPC: G01N33/74 ,  G01N33/58 ,  G01N33/553

CPC classification number: G01N33/74 ,  G01N33/54313 ,  G01N33/54346 ,  G01N33/553 ,  G01N33/582 ,  G01N33/587 ,  G01N2333/695

Abstract: The present invention provides a reagent kit which is used for measuring a test substance in a biological sample and can improve measurement sensitivity of the test substance; measurement kit; and a method of measuring the test substance. Provided is a reagent kit which is used for measuring the above-described test substance in the biological sample and contains first particles which are modified by a first binding substance having specific binding properties with respect to the test substance and have a label, and a compound which has at least one amino group having a positive charge.

Abstract translation: 本发明提供了一种用于测量生物样品中测试物质并可提高测试物质的测量灵敏度的试剂盒; 测量套件; 以及测定被检物质的方法。 提供一种试剂盒，其用于测量生物样品中的上述测试物质，并含有由相对于被检物质具有特异性结合特性的第一结合物修饰并具有标记的第一颗粒和化合物 其具有至少一个具有正电荷的氨基。

公开(公告)号：US20140295468A1

公开(公告)日：2014-10-02

申请号：US14229634

申请日：2014-03-28

Applicant: FUJIFILM Corporation

Inventor： Noriyuki KASAGI ,  Hiroyuki CHIKU ,  Dai UJIHARA ,  Toshihide YOSHITANI

IPC: G01N33/543

CPC classification number: G01N33/54306 ,  G01N33/54366 ,  G01N33/582 ,  G01N33/585

Abstract: The test substance assay method includes (i) obtaining a mixed solution by mixing (a) first dry particles that are modified with first binding substances exhibiting binding properties specific to a test substance, have an average particle size of 100 nm to 200 nm, and have labels, and (b) second dry particles that are modified with second binding substances not exhibiting binding properties specific to the test substance, have an average particle size of 100 nm to 200 nm, and do not have labels with (c) a test sample solution containing the test substance; (ii) applying the mixed solution onto a substrate; (iii) causing the test substance to be trapped in a reaction site on the substrate that has third binding substances having binding properties specific to the test substance or has substances exhibiting binding properties to the first binding substances; and (iv) detecting the test substance.

Abstract translation: 测试物质测定方法包括：（i）通过混合（a）第一干燥颗粒，所述第一干燥颗粒用具有特定于测试物质的结合特性的第一结合物质进行改性，平均粒径为100nm至200nm，以及 具有标签，并且（b）用不具有特定于测试物质的结合特性的第二结合物修饰的第二干燥颗粒具有100nm至200nm的平均粒度，并且没有标记（c）测试 含有测试物质的样品溶液; （ii）将混合溶液施加到基材上; （iii）使测试物质被捕获在具有与测试物质特异性结合特性的第三结合物质或具有与第一结合物质具有结合性的物质的基材上的反应部位中; 和（iv）检测测试物质。

公开(公告)号：US20150355175A1

公开(公告)日：2015-12-10

申请号：US14730378

申请日：2015-06-04

Applicant: FUJIFILM Corporation

Inventor： Nobuhiko FUJIWARA ,  Noriyuki KASAGI ,  Toshihito KIMURA ,  Kazuhiro NAKAMURA

IPC: G01N33/543

CPC classification number: G01N33/54386 ,  G01N21/553 ,  G01N21/64 ,  G01N21/648 ,  G01N21/82 ,  G01N33/54373 ,  G01N33/553 ,  G01N2021/825

Abstract: To provide a test substance measurement method and a test substance measurement kit adapted to improve the accuracy of the measurement of a test substance. A test substance measurement kit includes: fluorescent particles which are modified with a first binding substance having specific bindability to a test substance; non-fluorescent particles which are modified with a second binding substance having no specific bindability to the test substance; and a substrate on which a first metal film to which a third binding substance having specific bindability to the test substance is fixed, and a second metal film to which a fourth binding substance having no bindability to the test substance, but having bindability to the first binding substance is fixed, and which has a smaller thickness than the first metal film are formed.

Abstract translation: 提供测试物质测量方法和用于提高测试物质测量精度的测试物质测量套件。 测试物质测量试剂盒包括：用与测试物质具有特异性结合性的第一结合物修饰的荧光颗粒; 用对被检物质没有特异性结合性的第二结合物修饰的非荧光粒子; 和固定具有与测试物质具有特异性结合力的第三结合物质的第一金属膜的基材，以及第二金属膜，对测试物质不具有粘合性但与第一粘合物具有粘合性的第四结合物质 固定物质，并且形成比第一金属膜小的厚度。

公开(公告)号：US20240124389A1

公开(公告)日：2024-04-18

申请号：US18495200

申请日：2023-10-26

Applicant: FUJIFILM Corporation

Inventor： Shintaro TANABE ,  Tatsuya NITABARU ,  Mashiko YAMAMOTO ,  Hirofumi FUKUNAGA ,  Naoto NAKAMURA ,  Noriyuki KASAGI ,  Taisuke ENDO ,  Keiko SUZUKI

IPC: C07C229/26 ,  A61K9/127 ,  C07C229/28

CPC classification number: C07C229/26 ,  A61K9/127 ,  C07C229/28

Abstract: An object of present invention is to provide a compound or a salt thereof constituting lipid particles that can achieve a high nucleic acid encapsulation rate and excellent delivery of nucleic acids, and to provide lipid particles and pharmaceutical composition using the compound or a salt thereof, which can achieve a high nucleic acid encapsulation rate and excellent delivery of nucleic acids. According to an aspect of the present invention, a compound represented by Formula (1) or a salt thereof is provided.




In the formula, each symbol has a meaning defined in the present specification.